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Re: Citalopram pharmacology -Dr. Dave pharmrep

Posted by Ritch on August 20, 2002, at 13:10:54

In reply to Re: Citalopram pharmacology -Dr. Dave Ritch, posted by pharmrep on August 20, 2002, at 11:42:31

> NO.....10mg Lex is 40mg of me.


I wished somebody would do receptor affinity profiling for r- and s- citalopram separately. If the r- isomer has little affinity for the serotonin reuptake transporter, it (the r-isomer) possibly could have an increased affinity for other receptors involved with side effects. I did find it interesting in the micromedex link posted a while ago that the half-life of s-citalopram is about 22 hrs and that the half-life of s+r-citalopram is about 35 hrs. (If that is inaccurate-please somebody correct me).






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