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Re: Lexapro is different dr. dave

Posted by pharmrep on August 20, 2002, at 11:38:30

In reply to Lexapro still isn't different - pharmrep, posted by dr. dave on August 20, 2002, at 5:48:24

> I'm sure you believe Lexapro is different, pharmrep, but can't you see that you might not be in a position to make the most balanced of judgements on the evidence? It is not really convincing to try to persuade people it is different just by insisting that it is.
> Turning to the isomer science, why are there no plausible theories at all as to how removing r-citalopram could increase speed of onset and efficacy? We know it doesn't affect the pharmacokinetics of s-citalopram and we know that it has about 1/30th the affinity for the serotonin reuptake transporter of s-citalopram so it can't be competing at the binding site. It really is inert. Lundbeck, who developed the drug, still had no theory to back up the claim that r-citalopram impedes s-citalopram's activity when I last spoke to them. Does Forrest?
> I would be more than happy to discuss the deficiencies in the published papers if you wish. Independent reviews of the evidence wouldn't both come to the same conclusion for no reason.

*** Yes, and I've gone through credibilty before here. I find it interesting...all the opinions that are subjectively based. If I see statements that are completely one-sided...I like to jump in. Especially ones I have facts on. I have plenty of studies to back the differences you? The 9 done all show statistically significant differences, so what are you referring to when you make your statements. (Did you participate in "early studies?") I am guessing you havent read the studies... primarily because you insist there is no pharmacokinetics in r-citalopram. Yes is does not help in the treatment of depression, but it definitely was inhibiting s-citalopram (ie...r attaches to histomine receptors sites which can cause somnolence). And Lundbeck just spoke to Forest in late June in Atlanta (I was there) about the "US" studies and how more was uncovered than in the European studies. Cool, I would love to chat with you...what city are you in?




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