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Re: Citalopram pharmacology -Dr. Dave

Posted by Ritch on August 20, 2002, at 9:37:03

In reply to Citalopram pharmacology - Mitch, posted by dr. dave on August 20, 2002, at 5:21:03

> 'Celexa' 20mg is 10mg s-isomer and 10 mg r-isomer. The r-isomer is effectively inert as an SSRI or anything else. Celexa only works because of the 10mg s-isomer in it. 'Lexapro' is the 10mg s-isomer on its own. It's pretty hard and expensive to produce separately, and it's a funny thing to do when the r-isomer has virtually no pharmacological action at all.
> Lexapro 10mg is Celexa 20mg with 10 mg of an inert substance expensively removed.

<from other post>
We know it doesn't affect the pharmacokinetics of s-citalopram and we know that it has about 1/30th the affinity for the serotonin reuptake transporter of s-citalopram so it can't be competing at the binding site.

Thanks for those added tidbits of information! I knew that r-citalopram had less affinity for the serotonin reuptake transporter, but not 1/30th... Then, the only thing left to consider is the notion of r-citalopram *causing* side-effects (commonly associated with SSRI's) with little affinity for the serotonin reuptake transporter.





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