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Re: Why is my Zoloft not working?

Posted by LostBoyinNC1 on July 28, 2002, at 10:34:18

In reply to Re: Why is my Zoloft not working?, posted by cybercafe on July 28, 2002, at 1:43:42

> > What is atypical/vegetative and melancolic/retarded? Could you explain?
> atypical/vegetative usually means there is mood reactivity (more than 50% of your depression lifts from time to time in pleasurable situations) ... also there are vegetative symptoms such as oversleeping and eating more... (hyperphagia and hypersomnia)
> melancholic/retarded .. involves no mood reactivity .. insomnia... and eating less/weight loss i believe... and possibly slowed speech, slowed thoughts... or slowed movement ... but mood reactivity is the primary indicator ...
> most depressives are atypical
> melancholic depression seems to respond favourably to tricyclics
> atypical depression seems to respond favourably to MAOIs, but poorly to tricyclics...
> good luck

The above is all true, however severe endogenous depression (melancholia) responds best to bilateral and bifrontal ECT. Also, severe melancholic depression responds great to the MAOI Parnate. The MAOIs are useful not in just atypical depressions, but can also be very effective in severe endogenous depressions.

Many cases of severe melancholia the best choices are either ECT or high dose Parnate.




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