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Re: JohnX2, How are you? Jackd

Posted by JohnX2 on June 4, 2002, at 22:08:49

In reply to Re: JohnX2, How are you?, posted by Jackd on June 4, 2002, at 15:09:09

> An old acquiantance of mine told me she found great success after 8 years with that combo (Lamictal + Topomax). Yeah, I'm on summer break, so I have some time to really mess around with the meds. Right now I'm on 30mg of Remeron with 1500mg of Lithium and have been somewhat stable and functional for a few months. So to me, that's a success, or at least a step in the right direction. It was funny though, I went all the way up to 1200mg on the Lithium and I was still cycling like crazy, but when I hit the 1500 mark it suddenly stopped (and incidentally my trough blood level had finally reached .59, just about therapeutic. I had just about given up too.
>
> The lithium is good stuff, I do have to say, but it makes me tremble a bit when I get nervous or excited.
>
> I'm starting Lamictal and in a few months I'll be at a therapeutic level, in hopes of eventually substituting it for Lithium.
>
> Now you said you felt hypomanic on the L and T combo? Doesn't sound too bad to me. Did you have a lot of anxiety? How are they on their own? Is there a synergy of some kind you think? I've been doing A LOT of reading on neurotransmitters and pharmacology but when you get to the mood stabilizer mechanisms it's like a whole new dimension. If I remember you have neuropathic pain, right (don't know if that's what it's called)? I was reading about some involvement with NMDA receptors, among other things.
>

I become very euporic on L+T and this elevated into agitation, restlessness, anger.
The Lamictal alone is a mild AD, it leaves me a bit anergic depressed. I haven't tried
Topamax by itself.

I think there is a synergy in how they modulate glutatamate.
Lamictal acting at the NMDA receptor and Topamax at the AMPA receptor.

> Well anyway, good luck with your meds. (Correct me if I'm wrong, you're on Lamictal and Serzone, and you're adding in Lithium right?)

Thanks. I hope this lithium works. I'm really dragging my feet on making the
medicine moves, I need to move quicker.

Good luck with the Lamictal augmentation.

Best Wishes,
John


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