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Re: Despiramine geno

Posted by JohnX2 on June 1, 2002, at 23:42:47

In reply to Despiramine, posted by geno on May 28, 2002, at 16:52:50

> Desipramine has been mind boggling for me. My pdoc says its good for sleep and anxiety, but it seems to boost more norepinephrine. Im not panicy on it, but i feel a tingly sensatioin through my head and raised heart rate. No social phobia benifits. I think adderal/ritalin or dexadrine are better for social states than desipramine. I dont like my heart racing, esp when working out.
> I dropped desip, and took some ritalin, which mad me feel a bit better, along with zoloft and klonopin. But i still dont have my zoloft to 100mg yet. Im still not out going social finatic as i wanna be.
> geno

Are you taking this Desipramine with Remeron?

The Desipramine is a norepinephrine reuptake inhibitor.
In a key stress area of the brain called the locus coeruleus,
the firing rate of neurons is somewhat directly related to
stress/heart rate etc. Usually over time NRI's in this area
will increase norepinephrine in the synapse but slow down the
firing rate by desensitizing norepinephrine alpha-2 feedback receptors.
This helps with depression and anxiety.

Now Remeron blocks those alpha-2 feedback receptors, causing
an increase in norepinephrine release and firing rate on top
of the Desipramine reuptake inhibition maybe negating the
whole gig. Just a hypothesis on my behalf.

Pure blockade of alpha-2 norepinephrine receptors themselves have
been shown to induce panic attacks (like taking yohimbine
for some people). Remerons anxiolytic serotonergic action
helps to negate this. (I believe this is the case don't quote





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