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Nimodipine (an L-type Ca channel blocker) as AD?

Posted by fairnymph on May 28, 2002, at 2:35:10

It seems that nimodipine has been investigated and used as an antidepressant before, and with some success. Can anyone personally verify this?

Also, it seems that nimodipine can increase the efficacy of SSRIs and TCAs (tricyclics), which might be quite useful for those who are treatment resistant. Furthermore, as nimodipine is a Ca channel blocker, it reduces cardiovascular side effects (tachycardia etc) that some people find problematic when taking SSRIs and TCAs.


Cohen C, Perrault G, Sanger DJ. Assessment of the antidepressant-like effects of L-type voltage-dependent channel modulators.
Behav Pharmacol. 1997 Nov;8(6-7):629-38.

Czyrak A, Mogilnicka E, Maj J. Dihydropyridine calcium channel antagonists as antidepressant drugs in mice and rats.
Neuropharmacology. 1989 Mar;28(3):229-33.




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