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Re: Acamprosate where? Anna P.

Posted by JohnX2 on May 20, 2002, at 1:36:40

In reply to Re: Acamprosate where?, posted by Anna P. on May 17, 2002, at 0:52:46

> Do you know in which country in Europe, Acamprosate is available?
> I wonder if it could work as a mood stabiliser, just like Naltrexone has worked for me.
>
> Thanks,
>
> Anna P.

Hi Anna,

I know it is available in England. I'm not sure where else.

The mode of action of Acamprosate is quite different from
Naltrexone. Its definately not an apples-to-apples comparison.

There is some clinical interest in Acamprosate as a mood stabilizer
for treatment resistant bipolar (I saw an open study).

Naltrexone antagonizes (blocks) opioid receptors.

Acamprosate has 2 modes of action. It enhaces the release
at Gaba(b) receptors and it also weakly inhibits NMDA (excitatory)
transmission.

Take Care,
John


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URL: http://www.dr-bob.org/babble/20020517/msgs/107038.html