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Re: celexa and OCD

Posted by Dave1 on May 12, 2002, at 17:33:58

In reply to Re: celexa and OCD, posted by rainbowlight on May 11, 2002, at 0:35:21


Thanks for your responses. Here's my situation. I'm currently taking clomipramine for depression and OCD. I have augmented it with lithium and risperidal. The lithium augmentation helped the depression temporarily but neither lithium or risperidal helped the OCD.
I think I might try augmenting with citalopram (celexa I think). I found an article on PUBMED indicating this combo. might work. I'll show the article at the end of the post.



Citalopram for treatment-resistant obsessive-compulsive disorder.

Pallanti S, Quercioli L, Paiva RS, Koran LM.

Istituto di Neuroscienze and University of Florence Medical School, Florence, Italy.

We investigated the comparative efficacy of citalopram vs. citalopram administered with clomipramine, in treatment-resistant obsessive-compulsive disorder (OCD). Sixteen adult outpatients participated in a 90-day, randomized, open-label trial. Eligible patients were aged 18 to 45 years, had moderate to severe DSM-III-R OCD of >/= one year's duration, a baseline Yale-Brown scale (Y-BOCS) score of >/= 25 and no other active axis I diagnosis, and had failed adequate clomipramine and fluoxetine trials. The citalopram-plus-clomipramine group (n = 9) experienced a significantly larger percent decrease in mean Y-BOCS score by day 90 than the citalopram alone group (n = 7). Only one citalopram patient decreased her score by >/= 35%, and two by >/= 25%. All nine citalopram-plus-clomipramine patients experienced decreases of 35%. Side effects were mild to moderate in both groups. We also treated with citalopram six OCD patients who had not tolerated fluoxetine alone and clomipramine alone; three achieved Y-BOCS score decreases of >/= 35% at 90 days. Since citalopram does not significantly affect clomipramine metabolism, the improvement in the combined drug group is unlikely to have resulted from increased plasma clomipramine levels. Double-blind controlled trials are needed of citalopram in OCD, and of combining citalopram with clomipramine in treatment-resistant OCD.




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