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Re: phentermine and Effexor - djmmm

Posted by Bekka H. on March 28, 2002, at 10:44:34

In reply to Re: phentermine and Effexor, posted by djmmm on March 28, 2002, at 8:36:24

> well, phentermine stimulates the release of dopamine and norepinephrine, and acts as a re-uptake inhibitor, too; it has the same action as amphetamine...and is also dopamine neurotoxin
> It also acts as a MAOI. Typically this action isn't significant at regular doses...what dose were you taking

Hi djmmm,

That's very interesting about the MAOI activity of Phentermine. I wonder whether this might be one reason that that "Phen-Fen" diet pill that was popular a few years ago was so terribly dangerous? It was taken off the market due to its causing pulmonary hypertension and heart valve abnormalities. The "Fen" half of the pill was Fenfluramine, a serotonin releaser. It seems to me that a serotonin release combined with a med that has MAOI activity could be lethal, even if the MAOI activity was low to moderate.

By the way, how is phentermine a neurotoxin? I ask because another PB member told me that of all the stimulants, she had gotten most help from Dexedrine and Phentermine. I have also been helped greatly by Dexedrine and have thought of trying Phentermine, but I probably won't, now that I've read your post!





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