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zyprexa a cognitive enhancer augment? interesting

Posted by JohnX2 on February 21, 2002, at 17:29:08

Before I started Zyprexa I was worried that it
would make me really dizzy because it blocks a
alpha-1 noradrenaline receptor in a manner similar
to Serzone. But alas I found that Zyprexa does
not cause cognitive disfunction. Since then I
also have taken strong doses of Topamax and
also Neurontin without cognitive decline. Is
the Zyprexa helping?

I was postulating differences between Serzone
and Zyprexa when investigating some thoughts
about allergies and depression. When I start
Serzone I get a really bad flush in my face and
I feel really dizzy. This is consistent with getting
a histamine shot. There is a histamine feedback
receptor that inhibits the release of histamine,
serotonin, noradrenaline, and acetylcholine. This
effect will cause a cognitive decline. I believe
on Serzone this effect can make one feel a bit

Anyways both Serzone and Zyprexa still cause
weight gain by blocking the alpha-1 noradrenaline
receptor (makes you hungry). But Zyprexa has this
nice little widget that slightly antagonizes the
histamine "h3" feedback receptor and thus is a
pro-histaminergic medicine. I believe it will increase the
release of the monoamines noradrenaline, acetylcholine,
serotonin. Possibly this offsets any cognitive
declines from blocking the noradrenaline receptor.

So now that I take Zyprexa, my pdoc puts me back
on Serzone and I predict that I wont get all drunk
and have hot flashes and I am correct.

Ergo, I believe a pinch of Zyprexa (5 mg) can be
used as an adjunct to Serzone and maybe even
mood stabilizers to help with cognitive declines.






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