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Re: tools to offset Serzone cognitive issues?

Posted by JohnX2 on February 19, 2002, at 16:55:52

In reply to Re: tools to offset Serzone cognitive issues? Ritch, posted by Mr. Scott on February 18, 2002, at 23:09:28

> How about trazodone + Nortryptaline? create your own serzonelike creation with two other meds.
>

This is an interesting combination.
Trazodone is a more potent alpha-1 antagonist.
Are you going after the urinary retention?

This doesn't sound like a bad combo if I can
keep the anti-muscarinic side effects from
killing me.

A little more research into histamine-1 blockade
indicates that it faciliates the release of
serotonin. Does this imply that allergies can
diminish serotonin release? Anyways one of
Trazodones metabolites is something called mCPP.
This is a direct agonist of the serotonin receptor.
So basically all bets are off as to what the
presynaptic receptor is doing. Then the medicine
blocks the postsypantic 5ht-2 receptor. Maybe
all this gets around a foobar histamine system.
Interesting. If I could get Serzone or Trazodone
to work I would be home free.

-John


> By the way I've heard amitrptyline and Nortryptaline (it's metabolite) are the best TCA's for pain. I heard that this is because they affect membranes like tegretol, but I'm basically relaying theory here.
>
> Scott


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poster:JohnX2 thread:94516
URL: http://www.dr-bob.org/babble/20020215/msgs/94680.html