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Re: MAOI diet short list and Zyvox

Posted by djmmm on January 20, 2002, at 0:31:33

In reply to Re: MAOI diet short list and Zyvox , posted by fran on January 19, 2002, at 23:17:44

> I'm on Effexor for depression, but do know a
> little about MAOI and that they require diet
> restrictions which are not necessary for SSRIs.
> But now I've been started on Zyvox,which is a new
> antibiotic which has been out only about 2 months.
> It's used for serious infections with "super-bugs",
> i.e. bacteria that are resistant to all other
> existing antibiotics. Amazingly, it requires
> adherence to an MAOI diet, but I found this out
> only by looking it up in the new PDR. My doctor
> (an infectious diseases specialist) didn't tell me
> and there was no warning on the prescription
> bottle. *UNBELIEVABLE!!!*
> So, I'm very grateful to all of you for having
> already shared your experiences on-line. I had
> been following the old MAOI recommendations
> (sloppily provided even by my recently trained
> pharmacist), and was just resigned to a month or
> two of those restrictions (I totally admire all of
> you who have been doing this long-term). But even
> there, I had a ton of unanswered questions. Now
> I'm a much happier camper!
> BTW, I did read in a reputable (I think) article
> that, if you stop an MAOI, you have to continue
> the diet restrictions for an additional 4 weeks.
> Have any of you come across any information like
> this, or to the contrary?
> Thanks again, to all of you!

an irreversible covalent bond is formed by conventional MAOIs (non-reversible) so if discontinued, a new MAO enzyme must be resynthesized before "normal" MAO activity resumes... 4 weeks, seems a little excessive, but Im not a doctor.

also..Zyvox interacts with MAOIs because it is a MAOI itself,--so it also has potential interactions with SSRIs, TCAs, bupropion, and Buspar




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