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Re: GABITRIL (tiagabine) new anti-anxiety drug????? MB

Posted by Mitch on January 3, 2002, at 9:28:11

In reply to Re: GABITRIL (tiagabine) new anti-anxiety drug????? Mitch, posted by MB on January 2, 2002, at 23:52:38

> > > Right now, I'm only on the Trileptal and T4. I'm supposed to add the Prozac soon. Last night was the third night that I took 300 mg of Trileptal. This morning, I really realized how sleepy it is making me. It's not a bad sleepiness. I think antihistamine sleepiness feels *awful*, but this feeling is just kinda relaxing...almost like a benzo...but I worry about being able to go back to school this Monday to continue the year. Yesterday, I spent 14 hrs sleeping. What have you heard through the grapevine; have people been building tolorances to Trileptal sedation?
> >
> > Interesting. I felt noticeably *wired* when I was taking Trileptal (a definite stimulant like feeling-I even got up somewhat *early*). Maybe you ought to try 150mg twice daily before you increase to 150mg three times daily??
> > Oh BTW, I found Prozac very very activating. It may be that when you add in the Prozac you will see a reversal of the hypersomnia you are seeing now.
> Well, at 150 mg, the Trileptal gave me insomnia. Then, when I increased the dose to 300 mg, I didn't notice a change until the third night at that dose, after which I slept 14 hrs. Maybe I'm just catching up on the sleep I missed when I first started taking it. Also, today was the third day without caffeine...that can cause hypersomnia too. I just took my bedtime dose an hour ago (I take it a little early so I can get it in with some food) and I don't notice any sleepiness. Maybe I'm adjusting! All in all, it is really tolorable. I realize how much I disliked the Gabitril!! One weird thing, though: When my last dose started to "kick in" I began to have the physical sensations of a panic attack but it never got too bad...just dissipated

I would hazard a guess that it will probably be a little while and at somewhat higher doses of Trileptal before you are going to see what it is going to be like taking longer-term. I believe the dose "target" for seizures (as monotheraphy) is 1200mg/day (600mg/bid). Usually when you get into the range used for epilepsy you are more likely to see a lot of unwanted side effects (I am thinking here of cognitive sfx). Maybe your pdoc will be "nice" and you will get a good response before you get "there". Trileptal is related to Tegretol. I knew someone in college that had been on lithium for about 20 years for bipolar (he was a Navy vet)and he complained about the cognitive sfx of his lithium and they switched him to Tegretol. He definitely liked it a lot better. It would be nice to hear about a Trileptal success since Tegretol can cause nasty blood disorders (rare, but dangerous).

> > > Wellbutrin makes me extremely irritable (unless I pop some Xanax when it starts to kick in). I don't know that much about Provigil. I took something called adrafinil (similar to modafinil??) years ago. I don't think I liked was like drinking too much coffee. Do you know the differences between modafinil and adrafinil?
> > >
> > > MB
> >
> >
> > I think that modafinil is a metabolite of adrafanil. I believe the FDA won't let adrafanil in due to liver toxicity concerns.
> > I have had *some* irritability attributable to the WB. But, it is very short lived-I don't ruminate/adrenalize for hours afterwards. That is nice because I have taken other meds that increased hostility and I couldn't *put it down* (Effexor, Remeron, Buspar).
> >
> > Mitch
> What about Adderall, how did it affect hostility/anger? Also, have you heard about the Serzone--liver connection? I just read about that on Medline. I think I may not ask the doc about Serzone after all.
> MB

I had some intermittent grouchiness from it-but I don't think it was the Adderall so much as the fact I wasn't taking an SSRI with it (SSRI's really calm me down). The main thing about Adderall that was just so dramatic was the improved sleep quality, daytime alertness, and NO cycling. Nothing else ever just flattened it out like that-so weird.

Yes, I heard about the Serzone. I read about some isolated cases of liver probems associated with it before they had to include the warning in their script info., but I thought it was too rare to get that concerned. Actually, the thing about Serzone that I don't like is that it has too many metabolites (WB does too) and hits too many receptors (like Remeron).





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