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Re: Paxil vs. Celexa - differences, similarities? IsoM

Posted by Daveman on December 21, 2001, at 0:44:11

In reply to Re: Paxil vs. Celexa - differences, similarities? Cindylou, posted by IsoM on December 19, 2001, at 14:16:09

Hi Iso:

I'm no expert, but I'd bet one of the reasons you don't get the immediate "withdrawal blues" on Celexa as you did on Paxil is the difference in half-life. Paxil's half-life is around 20 hours, so if you miss one dose you start getting withdrawal immediately. Celexa, by contrast, has a half-life of 35-40 hours. It is well known that shorter half-life meds are almost always harder to get off. Since I'm about to try tapering down Celexa, I will certainly find out for myself:)





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