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Re: got a zanaflex prescription; wish me luck JohnX2

Posted by Mitch on November 30, 2001, at 23:42:26

In reply to got a zanaflex prescription; wish me luck, posted by JohnX2 on November 30, 2001, at 11:06:14

> I'm starting Zanaflex (tizanidine) today which
> is an anti-spasmodic dirivative of Clonodine.
> Supposedly a bit weaker without as bad sedation
> or anti-hypertensive side effects.
> Hopefully this will alleviate my Klonopin withdrawal
> as well as my tension headaches.
> I also think it may act as a good atypical mood
> stabilizer as it is a weak partial agonist of
> the noradrenaline alpha-2 receptors. This would help
> mediate firing in the stress centers of the brain.
> crossing my fingers,
> john

Hi John,

I hope this does some sort of *magic* for you. In my case the Wellbutrin is improving things with time. I feel a little wired, but I am not *losing my temper*. I really think your thoughts about WB slowing NE firing in the LC as opposed to A2 antagonists increasing NE firing is very accurate. I had a very confrontational experience with my boss today. On Remeron or Buspar I could easily picture getting reprimanded or fired after a big adrenalizing temper display. Instead, I just told my boss what I thought-in a calm *assertive* way and within an hour or so I was chatting with another coworker and smiling (not obsessing and ruminating over the confrontation-I had put it down and left it behind)!
This makes me wonder about alpha2 *agonists* as well.

Keep us posted on how this plays out,





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