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Re: got a zanaflex prescription; wish me luck SLS

Posted by JohnX2 on November 30, 2001, at 22:36:34

In reply to Re: got a zanaflex prescription; wish me luck JohnX2, posted by SLS on November 30, 2001, at 19:42:59


Hi Scott,

With my insurance I got a prescription of
1 month of zanaflex to be taken 4 mg at night
and 2 mg in the morning. Cost me $20. Not sure
what it would be without insurance. It seems
the therapeutic dose could vary wildly based off
what I read, so I'm not sure what will be
effective for me (if at all). If it works I will
push my neurologist to let me get the extended
release version from europe. I have also wanted
to try Tenex, but my pdoc is a weeny and poop-pooed
that idea. Tenex can be taken once a day and
is also supposed to be better than clonodine.

As a side not, I am still completly baffled at
how I am responding to the anti-histamine
chlorpheniramine maleate. I tend to get swelling,
sinus type pressure especially after staying up
for a long time or drinking too much caffeine to
the point that it no longer gets me a buzz and
sometimes if I drink alcohol I get head pressure.
I just reached a point 2 yrs ago when caffeine
would never give me a buzz and I always have these
weird headaches and then the severe mood problems.
I'm wondering if his whole stupid thing could be
allergy related. It started 4 yrs
after I moved to Austin. Shortly after I started
to become sensitive to allergies in Austin (which
is the allergy capitol of the world and people
tend to develop allergies after 2-4 yrs of
residency), I went down hill.
I have also noticed that at times if I travel say up north
and the weather is dry and the heat is on, then
I get a bad pressure headache. Anyways, I was
taking benadryl to help me sleep, but then stumbled
onto chlortrimetron and it didn't work well to
help me sleep, so I took a whopper dose and whamo,
no depression, and a dopamine buzz. Drinking caffeine
gives me a buzz and clears up sinuses like
taking pseudoephedrine. The effect doesn't poop
out??? I've heard of allergy induced depressions
and interactions between acetylcholine-noradrenaline
so that's where i am heading in my testing.

As far as neurontin went, It was well tolerated.
It helped relieve anxiety and peripheral tingling
from the klonopin withdrawal the last time I tried
to stop klonopin, but it never was really effective
at getting rid of the head pain and it didn't
allow for a robust anti-depressant response.

Lamictal is strange in that it has a small
thereapuetic window for me of 150-225 mg. If I
go to 300 mg, I get severe emotional numbing and
head pain. I know now from reading about nmda
receptors that there is a fine balance between
too much and too little stimulation.

Well I hope you find an anti-dote to your
problem. If the zanaflex doesn't work I'll
stay on the anti-histamine. Mean time I'm
going to study the muscarinic system some
more to figure why benadryl doesn't help
but chlorpheniramine does. At this point it
is whatever works.....

Regards,
John


> Hi John.
>
> > I've seen many references to Clonodine (Catapres)
> > being used for benzo withdrawl. I think this is
> > fairly common. I haven't seen much about Zanaflex.
>
> I was just becoming interested in tizanidine. I've already broached the subject of using clonidine with my doctor. He knows my feelings regarding my reactions to idazoxan and mirtazepine.
>
> I saw some stuff indicating that tizanidine might be as effective as clonidine in mitigating opioid withdrawal symptoms, but without the hypotensive side effects. I am looking forward to see you do well with it. Another drug that I would like to see brought to market is flesinoxan. Like buspirone, it is a 5-HT1a agonist. However, unlike buspirone (and ipsapirone), I don't think it has any metabolites that antagonize NE alpha-2 receptors. Woo hoo!
>
> I don't seem to be able to read or write in volume lately, so I apologize for not replying to some of your other posts. Besides, I would have to do quite a bit of remedial reading just to understand it all! So many interactions between circuits! I'm afraid I might blow the few I have left should I decide to try. :-) I am grateful that someone here is so strong at understanding neural circuitry and integrating it with the chemistry of neurotransmission.
>
> Is the Zanaflex being prescribed for myofacial pain? Is it expensive?
>
> By the way, how do you respond to Neurontin?
>
>
> - Scott


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