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Re: Morphine for depression. Elizabeth

Posted by SLS on November 30, 2001, at 7:43:58

In reply to Re: Morphine for depression. SLS, posted by Elizabeth on November 30, 2001, at 1:18:38

> > Have you ever tried amantadine (Symmetrel)? It's a long shot, but if Lamictal helped a little, perhaps amantadine could help augment or reduce the induction of tolerance to opioids via NMDA receptor antagonism.
>
> I didn't know that about Lamictal or amantadine.

Lamotrigine inhibits the release of glutamate, thereby reducing NMDA stimulation. Amantadine (a relative of memantine) blocks NMDA receptors. It was probably a dumb idea.

> I believe that the current thinking is that NMDA blockers don't really prevent tolerance, they just augment the opioid, alas.

I see.

> I've known a few people who used DXM to that end,

For opioid enhancement or for the prevention of desensitization? Did it work?


- Scott

 

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