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Re: a thought of my own Daveman

Posted by Cam W. on October 16, 2001, at 0:35:03

In reply to Thanks, Cam:) and a thought of my own Cam W., posted by Daveman on October 15, 2001, at 23:56:58

Dave - I haven't seen any good explanation of the electric zaps, yet. My feeling is, is that most clinicians and researchers either don't believe that they really exist, or feel that they are unrelated to withdrawl. This is similar to the instances when I first heard complaints of delayed weight gain with Paxil. A few years ago, when I would broach the subject with clinicians, they would say that there was no connection. This was when the scientific community believed that just as many people lost weight with Paxil, as gained weight. Now we know (because it has been "proven" scientifically) that some people lose weight in the short term with Paxil, but a majority will gain that weight back (and then some) in the subsequent 3 or 4 months of therapy.

Most psychiatrists have no idea what I am talking about when I mention "brain zaps". That is the problem with Psycho-Babble; we are just too damn current with what medications actually do. Clinically, we are way ahead of the research.

My hypothesis of what is going on with the brain zaps is that during withdrawl, the lack of serotonin in general, is causing random, unsychronized firing of serotonergic neurons. I am not totally sure in which part of the brain or which serotonergic pathway this is occurring, but I would hazard a guess that it is in one of the pathways leading out of the raphe nuclei (possibly enroute to the frontal cortex). I really don't know what is going on, though. It could also be a temporal lobe thing, similar to the feeling people get before an epileptic seizure, or maybe like the prodromal symptoms of a migraine headache.

Every time I think I am getting a grasp on the brain's circuitry, a question like this arises, and I realize that I don't understand the brain, as well as I think I do.

I guess that we have to organize and make more noise within the research community, so that someone takes our observations seriously. Perhaps Dr. Bob could get one of the depression experts to give a presentation so that we could lob our observations at him/her.

As confused as ever - Cam


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poster:Cam W. thread:5582
URL: http://www.dr-bob.org/babble/20011015/msgs/81374.html