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Re: CAM: question about neurokinin receptors Mitch

Posted by Cam W. on October 6, 2001, at 23:22:14

In reply to Re: CAM: question about neurokinin receptors Cam W., posted by Mitch on October 5, 2001, at 22:15:17

Mitch - I haven't looked much into neurokinin receptors or their inhibitors for a couple of years now. This is ever since Substance P blockers turned out to have to many side effects to be clinically useful. I think that neurokinin receptors are too widespread to be of any specific use in depression &/or pain modulation (I am not sure of this, though). Perhaps looking at the adenosine-1A (A1A) receptor may be more useful for finding a pain-control mechanism.

I know that MK-869 is being investigated in Britain (in Phase I trials) but I haven't paid much attention.

I have dwelt more on the cytokines and their role as second messengers intracellularly. There seems to be some connection with certain cytokines being involved with both the immune system and development of depression.

Sorry - Cam




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