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Re: Tricyclic spectrum?

Posted by Mitch on October 2, 2001, at 10:10:09

In reply to Tricyclic spectrum?, posted by Jackster on October 1, 2001, at 3:57:41

> Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are? For example, I know clomipramine is mainly serotonin reuptake inhibiting (and is making me really irritable) and amitriptaline is less serotonin and more of the other two (which I can't remember the names of). I've looked but can't seem to find anything that does this.
> Thanks
> Jackie

I came across a "transporter affinity" profile sheet once at my pdoc's. As far as TCA's go (from what I remember) the one at the top has the most affinity for the NE transporter and the ones toward the bottom increasing affinity for 5-HT transporters:
1) Desipramine
2) Nortripytline
3) Doxepin
4) Amitriptyline
5) Imipramine
6) Clomipramine

There are a few other TCA's, but I didn't see them listed.




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