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Re: Tricyclic spectrum?

Posted by Elizabeth on October 1, 2001, at 14:53:21

In reply to Tricyclic spectrum?, posted by Jackster on October 1, 2001, at 3:57:41

> Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are?

Not a web page off the top of my head, but I can give you a list if you'd like. The ones I am most familiar with are the ones available in the U.S., of which there are ten.

Tricyclics in general inhibit reuptake of monoamines, mainly norepinephrine and serotonin. (Dopamine is not generally affected to a significant degree.) They have cardiac side effects and can cause serious problems for people with certain types of cardiovascular disease. They also have "anticholinergic" side effects such as dry mouth and constipation, and some other side effects due to blockade of other receptor types.

Like I said, I can give you more details if you like, although I don't know of any particular web site that has the info (which is not entirely agreed-upon even by "experts," in any case).





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