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Re: grouch's rebound effect

Posted by andys on September 30, 2001, at 12:52:36

In reply to Re: andy's answer to all #2 » andys, posted by Grouch on September 20, 2001, at 21:26:20

I think I understand the phenomenon you referred to as “withdrawal positive rebound” (I figured it out myself, observing my own phenomena, for what it’s worth): When I quit a drug, the blood-level drops to the point where the side-effects go away, and the benefits (that were being masked by the side effects), show through. Because brain-levels are slower to clear out, you get the drug’s benefit for a short period, while the brain-level-concentration coasts down to a non-therapeutic level. (For me, the benefit lasts 4-5 days). Of course, if others have no side effects, my theory doesn’t hold water.
Also, for others who are very sensitive to side effects: Most pdocs will have you lower the dose, to better tolerate side effects over time, then titrate back up. I find it much more effective to completely quit the drug for 2-4 weeks. This seems to “re-set” my body, to better tolerate the drug for a second trial.
Regarding my anti-depressant response to Dexedrine, I really couldn’t characterize it as brief or sustained, since it’s just more of a “boost”, that will “nudge” me away from depression, in general. (I can “generally” say that I tend to be less depressed while on Dexedrine).




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