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Re: risperidone

Posted by John Bower on August 17, 2001, at 15:40:49

In reply to Re: risperidone judy1, posted by SLS on January 12, 2001, at 11:58:05

> Dear Judy,
>
>
> Thanks for ferreting out another investigational drug for us.
>
> Ziprazidone (Zeldox) is supposed to be approved for marketing imminently. It is very much like a Zyprexa, more so than aripiprizole, but without weight gain. After reading some of the few abstracts available on Medline about aripiprazole, I would not expect it to be much of an adjunct for depression (simplistic guess), but it makes for a novel way to approach schizophrenia as it acts as an agonist at presynaptic dopamine autoreceptors in addition to the usual antagonism of postsynaptic receptors.
>
> Where were you able to find out about aripiprizole? Do you have any good resources that provide information about investigational drugs?
>
> Thanks again.
> with. Bristol-Myers Squibb is running clinical trials on a variant of zyprexa that has no weight gain. It is called aripiprazole. I called them and got the name of local clinic doing the trials but it involves a 24 day hospital stay and they use a placebo (which is why you are probably hospitalized) That is not for me, but maybe others are interested. Take care- Judy

Aripiprazole worked in 9 days for depression in me (I think). I'm waiting for the mania to come now. A little tremor in hands left over from the residual lithium.

Aripiprazole has reduced the mania too and I am genuinely able to feel happiness and optimism even though I am out of a job right now.

Plus, aripiprazole doesn't cause weight gain, I've heard.

Sorry for sounding like a commercial for aripiprazole but it is the best medicene I've taken in a long time.


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