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Re: Lamictal: how long before it kicks in? Sal Thrud

Posted by SalArmy4me on July 30, 2001, at 22:53:39

In reply to Re: Lamictal: how long before it kicks in? Sal, posted by Thrud on July 30, 2001, at 22:44:23

Brannon, Guy E. MD *. Rolland, Philip D. RPh +. Anorgasmia in a Patient With Bipolar Disorder Type 1 Treated With Gabapentin. Journal of Clinical Psychopharmacology. 20(3):379-381, June 2000:

"During the first few years after approval by the FDA, new problems or side effects may emerge that were not seen during clinical trials, as illustrated by this case. A higher incidence of side effects or adverse events may be reported because the drug is being administered in a much larger population than that during clinical trials. The Physicians' Desk Reference describes a 1.5% incidence of impotence as measured by the Treatment-Emergent Adverse Event Incidence in controlled add-on trials. The inability to climax is listed as an adverse event under urogenital systems and is described as "infrequent." Infrequent adverse events are described as those that occur at a rate of less than 1%.

Physicians should address patient's concerns about sexual functioning relating to any type of pharmacotherapy that the patient may be receiving. This is especially true for patients receiving medications that may impair or alter sexual function. Likewise, when sexual dysfunction occurs, medications should be investigated as a likely cause, particularly selective serotonin reuptake inhibitors and antipsychotics. Antipsychotic medications can cause extrapyramidal symptoms, tardive dyskinesia, sedation, weight gain, and sexual dysfunction. Physicians should initiate discussions about sexual dysfunction as a side effect because some patients may be reluctant to report this problem spontaneously. Treatment of medication-induced sexual dysfunction should be individualized to the patient and should address specific and individual needs. This can be addressed by decreasing the dose of the offending medication, changing the medication (as was done in this case), or adding another medication such as cyproheptadine, Bethanecol, yohimbine, or amantadine. Future plans include conducting a survey of patients receiving gabapentin regarding sexual function to investigate whether this side effect is prevalent in a larger population of patients..."


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poster:SalArmy4me thread:72624
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