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Re: Lamictal: how long before it kicks in? Thrud

Posted by SalArmy4me on July 30, 2001, at 22:18:27

In reply to Lamictal: how long before it kicks in?, posted by Thrud on July 30, 2001, at 22:09:55

I've never thought of Lamictal as an anti-anxiety agent:

Botts, Sheila R.. Raskind, Jackie. Gabapentin and lamotrigine in bipolar disorder. American Journal of Health-System Pharmacy. 56(19):1939-1944, October 1, 1999.
"Lamotrigine was well tolerated in most patients, even when added to concomitant mood stabilizers. The most common adverse effects were nausea, headache, tremors, dizziness, somnolence, fatigue, ANXIETY..."

Gabapentin is a better choice for anxiety:

Frye, Mark A. MD. A Placebo-Controlled Study of Lamotrigine and Gabapentin Monotherapy in Refractory Mood Disorders. Journal of Clinical Psychopharmacology. 20(6):607-614, December 2000:

"GBP, which has a favorable pharmacokinetic profile, is renally excreted, has few interactions with other agents, is clinically well-tolerated, and has a low risk of toxicity,49 would seem to be promising for investigation as an add-on agent rather than in monotherapy, as assessed in this study. Additional preliminary reports suggest that this drug may possess antinociceptive 59 and anxiolytic properties,60-62 which may also provide a greater therapeutic yield in mood disorders complicated by comorbid pain syndromes, social phobia, anxiety, or insomnia..."




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