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Re: Prozac+Zyprexa Special for Treatment Resistence

Posted by SLS on October 25, 2000, at 21:38:56

In reply to Prozac+Zyprexa Special for Treatment Resistence, posted by JohnL on October 25, 2000, at 17:22:21


There have been clinical trials of Prozac + Zyprexa for about a year now. I don't know if there is anything particularly special about Prozac specifically when combined with Zyprexa, except that both drugs are sold by Eli Lilly. Lilly has sponsored these studies. I doubt the synergy of Prozac with Zyprexa is unique among SSRIs.

- Scott

> Hi all. I was doing a little research at and stumbled onto this interesting study. Just thought I would pass it on. It seemed interesting and intriguing. It's amazing how different each medicine is. Anyway, it seems Prozac + Zyprexa have some unique synergy that isn't duplicated with Zoloft or other antipsychotics. Something unique about this combo. For whoever's interested.
> John
> 1: Neuropsychopharmacology 2000 Sep;23(3):250-62
> Related Articles, Books,
> LinkOut
> Synergistic effects of olanzapine and other
> antipsychotic agents in combination with fluoxetine on
> norepinephrine and dopamine release in rat prefrontal
> cortex.
> Zhang W, Perry KW, Wong DT, Potts BD, Bao J, Tollefson GD,
> Bymaster FP
> Neuroscience Research Division, Lilly Research Laboratories, Lilly
> Corporate Center, Indianapolis, IN 46285-0510, USA.
> To understand the mechanism of the clinical efficacy of olanzapine and
> fluoxetine combination therapy for treatment-resistant depression (TRD),
> we studied the effects of olanzapine and other antipsychotics in
> combination with the selective serotonin uptake inhibitors fluoxetine or
> sertraline on neurotransmitter release in rat prefrontal cortex (PFC) using
> microdialysis. The combination of olanzapine and fluoxetine produced
> robust, sustained increases of extracellular levels of dopamine ([DA](ex))
> and norepinephrine ([NE](ex)) up to 361 +/- 28% and 272 +/- 16% of the
> baseline, respectively, which were significantly greater than either drug
> alone. This combination produced a slightly smaller increase of serotonin
> ([5-HT](ex)) than fluoxetine alone. The combination of clozapine or
> risperidone with fluoxetine produced less robust and persistent increases
> of [DA](ex) and [NE](ex). The combination of haloperidol or MDL
> 100907 with fluoxetine did not increase the monoamines more than
> fluoxetine alone. Olanzapine plus sertraline combination increased only
> [DA](ex). Therefore, the large, sustained increase of [DA](ex),
> [NE](ex), and [5-HT](ex) in PFC after olanzapine-fluoxetine treatment
> was unique and may contribute to the profound antidepressive effect of
> the olanzapine and fluoxetine therapy in TR




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