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Re: High doses of Parnate

Posted by Steeler Tookahn on October 22, 2000, at 8:45:37

In reply to Re: High doses of Parnate, posted by SLS on October 21, 2000, at 18:30:50

Thanks very much Scott,
I'm glad to get an idea of the kind of doses people are using these days. I read Jay Amsterdam's paper on high doses of Parnate.
I'm also glad to see people using TCAs with MAOIs. I've tried practically everything as an adjunct with little success. A tri-cyclic may be in the future.

>I have come across some research studies that indicate that Parnate begins to do things at high dosages that it does not do at lower dosages that are unrelated to MAO inhibition. One such effect is the downregulation of 5-HT2 receptors, something that occurs with several other antidepressants. Unlike Nardil, Parnate has been shown to produce a decrease in dopamine D2 receptor densities.

Scott -could you elaborate on what this downregualtion might mean to the patient. My knowledge of neurobiology (as well as my Neurobiology itself) is not what it used to be. I don't think I could tell an Axon from a Dendrite without a microscope (that's an attempt at humor).




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