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Re: MAO-B inhibitor + dopamine-releaser dangerous? S.D.

Posted by Rick on July 22, 2000, at 2:20:27

In reply to Re: MAO-B inhibitor + dopamine-releaser dangerous?, posted by S.D. on July 20, 2000, at 16:06:40

> > Andrew, thanks for the info. I've been taking kava on and off for a while, and you are saying that it's a MAO-B inhibitor? Am I interpreting correctly? I did read in a book that kava is similar in action to Klonopin. BTW has anyone gotten sex urges after taking kava?
> >
> Pharmacopsychiatry 1998 Sep;31(5):187-92
> Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper
> methysticum Forster (kava-kava).
> ----------
> more on Kava:
> ------------
> Kava reduced my social anxiety similarly to Klonopin. Perhaps not as much, but without as much tiredness or negative cognitive effect (may be having some of that with Klonopin, fairly subtly). I am taking both now in moderation, attempting to get good efficacy with minimal side effects from either. Though they might be synergistically increasing the sedation effect.
> No particular sex urges due to Kava. More morning wood recently, but I haven't been keeping careful notes.
> peace and health,
> S.D.

S.D., would you mind sharing (1) your daily dosage of Klonopin, including dosing schedule, (2) how long you've been taking it, and (3) whether you're taking anything other than K & KK?

I'm always curious about the dosing when someone who takes Klonopin daily talks about it causing fatigue. When I began taking it, I was surprised to find that taking LESS actually worked a lot better for my Social Anxiety. When I went from 2.5-3.0 mg. a day down to 1.5-2.0, it not only worked much better in relieving my Social Anxiety, but it also eliminated all traces of fatigue or slowness (I'm now at 1.25 mg/day, but with Serzone and Provigil as well). Even when the daily dose is low enough, taking more than 1.0 mg at a time also reduces benefits for me and brings back at least temporary sluggishness. I wish that the widely-circulated, dated Brazilian article that recommends 3.0-6.0 mg/day would just disappear from the net, especially from Doctor Bob's site!! Almost all other research, including reputable, placebo-controlled studies, suggest prime efficacy at doses maxing out at 3.0 mg. And they're NOT lowballing the dosage recommendations simply due to concerns over dependence or addiction.

Also, I find it of interest that when people are taking a maintenance benzo with an AD, they tend to assume the benzo is the med driving the fatigue.





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