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ZANNAH! ,Re: Remeron/Adam, question??

Posted by Adam on May 8, 2000, at 19:02:43

In reply to Re: Remeron/Adam, question??, posted by Zannah on April 27, 2000, at 17:09:33

Dear Zannah,

I'm sorry I missed your post. I came across it searching for
another old thread, and thus just realised that I missed it.
My apologies.

Anyway, to answer your question (I hope it's not too late), by
"histaminergic" (I must confess I don't remember what post this
was) I must have meant that Remeron is, in addition to its
other effects (5-HT2 & 3 antagonist, alpha-adrenergic receptor
agonist), has antihistamine properties. So, like other
antihistamines, it causes things like sedation, a mild anxiolytic
effect, and weight gain. It has been proposed that a "benefit"
of Remeron is this sedating/anxiolytic property, which, in a
nutshell, should help nervous patients sleep, and is realised
almost immediately.

I certainly can't argue with that logic, as Remeron does indeed
deliver those effects. However, at least for some, "sedation" is
seemingly a euphamism for "severe hypersomnolence". I found
this side effect more of a nuisance than anything. I will admit
there was one really cool, related side-effect: Incredibly vivid
dreams. I call Remeron "the dream pill" in the most literal sense.
It didn't help me greatly with depression, but I had simply
amazing dreams while on it, pretty much every night.

> Adam,
> You mentioned the word 'antihistaminergic' (I think) when discussing Remeron (last Dec). What does this mean? Is it another way of saying sedating, in the way that antihistamines sometimes are?
> I began Remeron 1 week ago. Took 7.5 for 2 days, then 15mgs. nightly for the next 4 (as I will do again tonight).
> So far, I have not found it to be sedating, but I am pretty wound up right now, due to financial strains, and I am in the middle of moving-YUK.
> And, did u mention that Remeron is known for being a pretty quick acting drug? Boy, wouldn't that be a blessing?
> So far, I have noticed no difference in my mind-set/attitude. Hope something kicks in soon. I have samples to last 2 more weeks at 15 mgs. a day.We shall see...Thanks~Zannah




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