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Re: Naltrexone

Posted by Elizabeth on February 10, 1999, at 16:44:45

In reply to Naltrexone, posted by Paul on February 8, 1999, at 9:36:39

> It is my understanding that Naltrexone is an opioid antagonist, and as such, does bond to the same receptors that codeine does, but does not activate them, and thus produces none of the analgesic or euphoric effects of codeine. It would in fact counteract the effect of opioid agonists like codeine. It is the interest of agonists or mixed agonists/agonists on depression, I think is what is of interest regarding codeine.
> But I could be wrong.

At least as far as naltrexone goes you are right. Codeine is actually a pure agonist, but there has been some interest in mixed agonist/antagonists.




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