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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 20 of 20. This is the beginning of the thread.
Posted by Kimbersaur on March 29, 2009, at 15:04:11
Has anyone heard anything about N-acetylcysteine and OCD? Is it safe to take with psych meds?
Posted by Larry Hoover on March 29, 2009, at 21:33:51
In reply to N-acetylcysteine and OCD, posted by Kimbersaur on March 29, 2009, at 15:04:11
> Has anyone heard anything about N-acetylcysteine and OCD? Is it safe to take with psych meds?
Yale is still recruiting for a clinical trial of NAC as an adjunct for OCD. Dosage is 3000 mg/day, and it is in addition to the subjects' existing psych meds. I cannot think of a contraindication between a psych med and NAC.
Here's the clinical trial info:
http://clinicaltrials.gov/ct2/show/NCT00539513?term=n-acetyl+cysteine+obsessive+compulsive&rank=1Lar
Posted by myco on March 30, 2009, at 17:43:38
In reply to N-acetylcysteine and OCD, posted by Kimbersaur on March 29, 2009, at 15:04:11
Don't know about the OCD but I use this compound for it's expectorant/anti mucus properties as I am ill and it works better than the puffer they gave me.
Some feelings about it:
- makes me feel happy while on it...starts about 1h from dosing
- makes me very drowsy especially about 2-3h after dosing
- you dont need much...about 250mg to feel it come on
- seems to close off negative thoughts to some extent...interesting possability for augmentation
- reducing coughing alot
- may make your nose run
- mild headache if you take too much the next day plus mild depressive symptoms if you take too much the next day.
- definately helps sleep
- interesting lil head buzz or warmth feelings after dosing...a feeling of "coolness" (dont know how else to explain that) in my chestthose are my observations of that supplement thus far. I thank larry for it's recommendation.
myco
----------------------
> Has anyone heard anything about N-acetylcysteine and OCD? Is it safe to take with psych meds?
Posted by myco on March 30, 2009, at 17:44:34
In reply to Re: N-acetylcysteine and OCD » Kimbersaur, posted by myco on March 30, 2009, at 17:43:38
Forgot to mention....I take this supplement safely on Nardil (a maoi AD)
> Don't know about the OCD but I use this compound for it's expectorant/anti mucus properties as I am ill and it works better than the puffer they gave me.
>
> Some feelings about it:
> - makes me feel happy while on it...starts about 1h from dosing
> - makes me very drowsy especially about 2-3h after dosing
> - you dont need much...about 250mg to feel it come on
> - seems to close off negative thoughts to some extent...interesting possability for augmentation
> - reducing coughing alot
> - may make your nose run
> - mild headache if you take too much the next day plus mild depressive symptoms if you take too much the next day.
> - definately helps sleep
> - interesting lil head buzz or warmth feelings after dosing...a feeling of "coolness" (dont know how else to explain that) in my chest
>
> those are my observations of that supplement thus far. I thank larry for it's recommendation.
>
> myco
>
> ----------------------
>
>
> > Has anyone heard anything about N-acetylcysteine and OCD? Is it safe to take with psych meds?
>
>
Posted by desolationrower on March 30, 2009, at 21:56:18
In reply to Re: N-acetylcysteine and OCD, posted by myco on March 30, 2009, at 17:44:34
interesting the connection between OCD and cued drug-seeking behavior, both improved by NAC
-d/r
Posted by g_g_g_unit on March 31, 2009, at 16:38:34
In reply to Re: N-acetylcysteine and OCD, posted by desolationrower on March 30, 2009, at 21:56:18
i've been meaning to try NAC for a while now after hearing about its supposed efficacy w/r/t OCD. the only issue is i'm already taking acetyl-l-carnitine on an empty stomach upon waking - followed by my morning dose of Nardil fifteen minutes later. if i were to take NAC would that require a further waiting period, or can i just take it at the same time as the ALCAR?
Posted by desolationrower on March 31, 2009, at 21:48:24
In reply to Re: N-acetylcysteine and OCD, posted by g_g_g_unit on March 31, 2009, at 16:38:34
i do'nt see why any of those would have problems being absorbed
-d/r
Posted by Kimbersaur on April 1, 2009, at 12:41:14
In reply to N-acetylcysteine and OCD, posted by Kimbersaur on March 29, 2009, at 15:04:11
Does anyone know where to buy this stuff? Is it like a vitamin shop thing or a pharmacy type of thing?
Posted by myco on April 1, 2009, at 12:45:48
In reply to Re: N-acetylcysteine and OCD, posted by Kimbersaur on April 1, 2009, at 12:41:14
It's a supplement available widely in sup/herbal stores....my fav american site based in Cali is:
www.iherb.com
cheap prices and cheap shipping, friendly knowledgeable staff....solely an online business.
They have this available in many different brands and cheap.myco
> Does anyone know where to buy this stuff? Is it like a vitamin shop thing or a pharmacy type of thing?
Posted by Kimbersaur on April 2, 2009, at 22:32:04
In reply to N-acetylcysteine and OCD, posted by Kimbersaur on March 29, 2009, at 15:04:11
Does anyone know if you are supposed to take Vitamin C with it or something? I think I read somewhere that it is really important to take Vitamin C with it which sort of freaks me out.
Posted by myco on April 2, 2009, at 22:37:30
In reply to Re: N-acetylcysteine and OCD, posted by Kimbersaur on April 2, 2009, at 22:32:04
Nah...with sups its typical to take on empty stomach to aid absorption plus many cofactors (compounds that aid in absorption and distribution etc) are helpful. So typically to get the most out of a supplement you want to make sure your body has lots of stuff like: folic acid, vit B3, vit B6, copper. Multivitamin basically. Vit C can also aid in absorption. Dont go out of your way though...take a multivitamin mabye a 30min to an hour before you take the sup.
If you dont have C will it effect NAC? no...it will just prevent it from absorbing and being available for use in your body at 100 percent. doesnt mean it wont work.
so multivitamin is a simple solution
--------
> Does anyone know if you are supposed to take Vitamin C with it or something? I think I read somewhere that it is really important to take Vitamin C with it which sort of freaks me out.
Posted by Kimbersaur on April 3, 2009, at 16:37:15
In reply to Re: N-acetylcysteine and OCD, posted by myco on April 2, 2009, at 22:37:30
Thank you so much for the information. It looks safe enough so I think I'll try it. Wish me luck!
> Nah...with sups its typical to take on empty stomach to aid absorption plus many cofactors (compounds that aid in absorption and distribution etc) are helpful. So typically to get the most out of a supplement you want to make sure your body has lots of stuff like: folic acid, vit B3, vit B6, copper. Multivitamin basically. Vit C can also aid in absorption. Dont go out of your way though...take a multivitamin mabye a 30min to an hour before you take the sup.
>
> If you dont have C will it effect NAC? no...it will just prevent it from absorbing and being available for use in your body at 100 percent. doesnt mean it wont work.
>
> so multivitamin is a simple solution
>
> --------
>
>
> > Does anyone know if you are supposed to take Vitamin C with it or something? I think I read somewhere that it is really important to take Vitamin C with it which sort of freaks me out.
>
>
Posted by myco on April 3, 2009, at 16:43:09
In reply to Re: N-acetylcysteine and OCD » myco, posted by Kimbersaur on April 3, 2009, at 16:37:15
Posted by mogger on May 7, 2009, at 11:47:45
In reply to N-acetylcysteine and OCD, posted by Kimbersaur on March 29, 2009, at 15:04:11
I am trying N-acetylcysteine for OCD. I was wondering if its effects are purely the glutamate modulation or does it also affect sodium and calcium channels?
mogger
Posted by morganpmiller on June 24, 2009, at 10:43:04
In reply to Re: N-acetylcysteine and OCD, posted by mogger on May 7, 2009, at 11:47:45
I wonder if a good undenatured whey protein like Jarrow's would have a similar effect. I'm thinking maybe the cystein in the whey may help in a similar whey(ha ha) to n acytel cystein. I know a good whey protein is beneficial for raising glutathione, same as NAC.
Posted by mogger on June 24, 2009, at 12:59:23
In reply to Re: N-acetylcysteine and OCD, posted by morganpmiller on June 24, 2009, at 10:43:04
Wow I would really be interested to perhaps try that and if anyone has tried that for OCD any thoughts would be great!
Posted by morganpmiller on June 24, 2009, at 15:21:30
In reply to Re: N-acetylcysteine and OCD, posted by mogger on May 7, 2009, at 11:47:45
> I am trying N-acetylcysteine for OCD. I was wondering if its effects are purely the glutamate modulation or does it also affect sodium and calcium channels?
> moggerIf you want something that modulates glutamate you may want to try a good resveratrol product:
Resveratrol Increases Glutamate Uptake, Glutathione Content, and S100B Secretion in Cortical Astrocyte Cultures
JournalCellular and Molecular NeurobiologySubject CollectionBiomedical and Life Sciences
SpringerLink DateThursday, June 07, 2007Original paper
Resveratrol Increases Glutamate Uptake, Glutathione Content, and S100B Secretion in Cortical Astrocyte CulturesLúcia Maria Vieira de Almeida1, Cristopher Celintano Piñeiro1, Marina Concli Leite1, Giovana Brolese1, Francine Tramontina1, Ana Maria Feoli2, Carmem Gottfried1 and Carlos-Alberto Gonçalves1 Contact Information
(1) Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, 90035-003, RS, Brazil
(2) Faculdade de Enfermagem, Nutrição e Fisioterapia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BrazilReceived: 4 November 2006 Accepted: 16 April 2007 Published online: 7 June 2007
Abstract Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a polyphenol present in grapes and red wine, which has antioxidant properties and a wide range of other biological effects. In this study, we investigated the effect of resveratrol, in a concentration range of 10250 μM, on primary cortical astrocytes; evaluating cell morphology, parameters of glutamate metabolism such as glutamate uptake, glutamine synthetase activity and glutathione total content, and S100B secretion. Astrocyte cultures were prepared of cerebral cortex from neonate Wistar rats. Morphology was evaluated by phase-contrast microscopy and immunocytochemistry for glial fibrillary acidic protein (GFAP). Glutamate uptake was measured using l-[2,3-3H]glutamate. Glutamine synthetase and content of glutathione were measured by enzymatic colorimetric assays. S100B content was determined by ELISA. Typical polygonal morphology becomes stellated when astrocyte cultures were exposed to 250 μM resveratrol for 24 h. At concentration of 25 μM, resveratrol was able to increase glutamate uptake and glutathione content. Conversely, at 250 μM, resveratrol decreased glutamate uptake. Unexpectedly, resveratrol at this high concentration increased glutamine synthetase activity. Extracellular S100B increased from 50 μM upwards. Our findings reinforce the protective role of this compound in some brain disorders, particularly those involving glutamate toxicity. However, the underlying mechanisms of these changes are not clear at the moment and it is necessary caution with its administration because elevated levels of this compound could contribute to aggravate these conditions.
Posted by morganpmiller on June 24, 2009, at 15:29:36
In reply to Re: N-acetylcysteine and OCD, posted by morganpmiller on June 24, 2009, at 15:21:30
You can take your resveratrol with your whey protein as some of the resveratrol will bind to the beta lactoglubin in the whey. This is a good thing.
Resveratrol may help in other ways that could treat OCD.Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activitystar, open
Purchase the full-text article
Received 27 February 2006.
Available online 17 April 2006.Abstract
This study investigated for the first time the potential effects of cis- and trans-resveratrol (c-RESV and t-RESV) on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake by synaptosomes from rat brain, on 5-HT uptake by human platelets, and on monoamine oxidase (MAO) isoform activity. Both c-RESV and t-RESV (5200 μM) concentration-dependently inhibited the uptake of [3H]NA and [3H]5-HT by synaptosomes from rat brain and the uptake of [3H]5-HT by human platelets. In both experimental models, t-RESV was slightly more efficient than c-RESV. Furthermore, in synaptosomes from rat brain, the RESV isomers were less selective against [3H]5-HT uptake than the reference drug fluoxetine (0.130 μM). On the other hand, both c-RESV and t-RESV (5200 μM) concentration-dependently inhibited the enzymatic activity of commercial (human recombinant) MAO isoform (MAO-A and MAO-B) activity, c-RESV being slightly less effective than t-RESV. In addition, both RESV isomers were slight but significantly more selective against MAO-A than against MAO-B. Since the principal groups of drugs used in the treatment of depressive disorders are NA/5-HT uptake or MAO inhibitors, under the assumption that the RESV isomers exhibit a similar behaviour in humans in vivo, our results suggest that these natural polyphenols may be of value as structural templates for the design and development of new antidepressant drugs with two important biochemical activities combined in the same chemical structure: NA/5-HT uptake and MAO inhibitory activity.
Posted by morganpmiller on June 24, 2009, at 15:48:29
In reply to Re: N-acetylcysteine and OCD, posted by mogger on June 24, 2009, at 12:59:23
I'm not so sure about my undenatured whey protein idea. Even the best whey protein may actually activate or increase glutamate, which could lead to excitability, making it harder to control OCD. I'm not sure really. I will say that a good whey protein is really good for your health for many reasons and may help you live a longer healthier life. So don't stay away from it. I use Jarrow's..one of the most affordable high quality whey proteins on the market; great for increasing glutathione.
Posted by Johnny Baklava on August 13, 2009, at 13:59:07
In reply to Re: N-acetylcysteine and OCD, posted by morganpmiller on June 24, 2009, at 15:48:29
When, generally, is the best time to take NAC? In the morning, or at night?
This is the end of the thread.
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