![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 14 to 38 of 38. Go back in thread:
Posted by KaraS on December 10, 2004, at 12:17:15
In reply to Re: URGENT! Please help me with asthma and panic » KaraS, posted by verne on December 9, 2004, at 23:13:42
> Kara,
>
> Have you tried a negative ion machine? Seems like they are getting bad press lately (not sure why) but whenever I use mine I sleep better. I have a niece with asthma who uses one and seems to benefit.
>
> I know that when I travel by air, I feel awful later and my throat is often sore or scratchy. Airplane air has zero negative ions.
>
> A water fountain is a natural way to create negative ions. Indoor models are becoming more affordable all the time.
>
> Hope you get to the bottom of your problem and feel better soon.
>
> verne
Thanks, VerneI haven't tried a negative ion machine though I'd like to for many reasons. They're supposed to be good for depression also. I just can't afford one now.
Take care. Hope you're doing ok.
Kara
Posted by KaraS on December 10, 2004, at 14:40:33
In reply to Re: URGENT! Please help me with asthma and panic » KaraS, posted by Larry Hoover on December 10, 2004, at 12:07:06
> The niacinamide is within twenty minutes.
Do you take that now as well or only periodically? Obviously it isn't enough for you or you wouldn't need your puffer, no?
>
> The NADH was certainly on lesser doses than that. I think later in the trial I was only taking 5 mg 2 or 3 times a week, and that was the oral form.
>
> I have no clue why I'm not taking some right now, considering the asthma thing. Back in a sec.
>
> Ok. Where were we?
>
> > If that isn't enough for me, I am wondering about the various medications that a doctor might give me. Taking steroids scares me. Dr. Weil said that Aerobid Inhaler is the best of the steroid inhalers because it has the least amount of systemic involvement. That could be old information by now though.
>
> I know the one I use has systemic effects. C'est le vie. Breathing is a priority.
>
> I never really gave it much thought, but I bet that I should.
>
> Do you see why I like getting into these discussions? I need the proper stimuli to even manage my own self-care. You have no idea how absent-minded I can be.Definitely the absent-minded professor. You're too funny!
> > I wish I knew how much of this is asthma/allergy related and how much is anxiety/panic. I guess I really need to see a good doctor. No easy feat without health insurance.
>
> http://www.marryacanadian.com/:-)
> > Lastly,
> >
> > > I hope you feel better soon.
> > >
> > > Lar
> > >
> >
> > Thanks so much.
> >
> > K
>
> You're welcome, hun.
>
> Lar
Posted by KaraS on December 10, 2004, at 15:19:57
In reply to Re: Also re: asthma and panic » KaraS, posted by GeishaGirl on December 10, 2004, at 1:35:54
> Hi Kara,
>
> Sorry, I forgot about this one when I mentioned asthma stuff before. Someone mentioned mullein. I know someone who has a case of asthma worse than mine. She actually told me that she found that *smoking* mullein was more effective than drinking it as a tea. Seems odd, but true. I tried it a couple of times, and it really does work well. She says that there are others who smoke it, as well.
>
> Take care,
>
> Geisha Girl
Hi,I've read about using the tea and the oil for asthma but never heard of smoking it. Sounds hardcore! :-)
Thanks,
K
Posted by Larry Hoover on December 10, 2004, at 16:39:11
In reply to Re: URGENT! Please help me with asthma and panic » Larry Hoover, posted by KaraS on December 10, 2004, at 14:40:33
> > The niacinamide is within twenty minutes.
>
> Do you take that now as well or only periodically? Obviously it isn't enough for you or you wouldn't need your puffer, no?I need an assistant.
> > Do you see why I like getting into these discussions? I need the proper stimuli to even manage my own self-care. You have no idea how absent-minded I can be.
>
> Definitely the absent-minded professor. You're too funny!You only hear about the difficulties I tell you about. You have no idea.
> > > I wish I knew how much of this is asthma/allergy related and how much is anxiety/panic. I guess I really need to see a good doctor. No easy feat without health insurance.
> >
> > http://www.marryacanadian.com/
>
> :-)Seriously, after three months residency, free health care. Marriage optional.
Lar
Posted by tealady on December 10, 2004, at 17:38:51
In reply to Re: URGENT! Please help me with asthma and panic » KaraS, posted by Larry Hoover on December 10, 2004, at 16:39:11
No easy feat without health insurance.
> > >
> > > http://www.marryacanadian.com/
> >
> > :-)
>
> Seriously, after three months residency, free health care. Marriage optional.
>
> Lar"In addition, I promise to help my new Yankee spouse to adapt to life in the great white north, keeping them safe from (gratuitous) invasion of privacy, and to provide him/her with a reasonable supply of Timbits."
OK..you explained the great white north b4, now what are Timbits!
Jan
Posted by Larry Hoover on December 10, 2004, at 20:49:37
In reply to Re: URGENT! Please help me with asthma and panic » Larry Hoover, posted by tealady on December 10, 2004, at 17:38:51
> No easy feat without health insurance.
> > > >
> > > > http://www.marryacanadian.com/
> > >
> > > :-)
> >
> > Seriously, after three months residency, free health care. Marriage optional.
> >
> > Lar
>
> "In addition, I promise to help my new Yankee spouse to adapt to life in the great white north, keeping them safe from (gratuitous) invasion of privacy, and to provide him/her with a reasonable supply of Timbits."
>
> OK..you explained the great white north b4, now what are Timbits!
> JanWas that on that website? Cute!
We have a donuts and coffee franchise operation called Tim Horton's (after a hockey player). They started marketing bite-sized donut pieces, round bits like the part they cut out of the center of a donut, as Timbits. Great in the car.
Lar
Posted by KaraS on December 10, 2004, at 23:20:41
In reply to Re: URGENT! Please help me with asthma and panic » KaraS, posted by Larry Hoover on December 10, 2004, at 16:39:11
> > > The niacinamide is within twenty minutes.
> >
> > Do you take that now as well or only periodically? Obviously it isn't enough for you or you wouldn't need your puffer, no?
>
> I need an assistant.
>
> > > Do you see why I like getting into these discussions? I need the proper stimuli to even manage my own self-care. You have no idea how absent-minded I can be.
> >
> > Definitely the absent-minded professor. You're too funny!
>
> You only hear about the difficulties I tell you about. You have no idea.
>
> > > > I wish I knew how much of this is asthma/allergy related and how much is anxiety/panic. I guess I really need to see a good doctor. No easy feat without health insurance.
> > >
> > > http://www.marryacanadian.com/
> >
> > :-)
>
> Seriously, after three months residency, free health care. Marriage optional.
>
> Lar
And I wouldn't have to feel embarrassed by our foreign policy ... think I'll pack my bags!
Posted by KaraS on December 10, 2004, at 23:23:02
In reply to Re: URGENT! Please help me with asthma and panic » Larry Hoover, posted by tealady on December 10, 2004, at 17:38:51
Posted by KaraS on December 12, 2004, at 1:31:01
In reply to Re: URGENT! Please help me with asthma and panic » KaraS, posted by Larry Hoover on December 10, 2004, at 16:39:11
> > > The niacinamide is within twenty minutes.
I only took 250 mg. and it really calmed me down while making it easier to breathe. It really took away the panic. It was amazing. I definitely won't need any benzos now. Are there any contraindications or drug interactions with this that you know of?
The only downside is that it made me tired. This would be an incredible sleeping pill for me too. I can't tolerate Benadryl but there would be no need to with B3 on hand. I wonder if I drank coffee with it or took a sudafed if that would allow me to feel more awake while also serving as bronchodilators.
Also, I've read that long-term antihistamine use can cause or worsen depression. I wonder if that would apply to long-term B3 intake?
Thanks so much for suggesting this to me!
K
Posted by Larry Hoover on December 12, 2004, at 10:34:10
In reply to Re: WOW! Niacinamide really works! » Larry Hoover, posted by KaraS on December 12, 2004, at 1:31:01
> > > > The niacinamide is within twenty minutes.
>
> I only took 250 mg. and it really calmed me down while making it easier to breathe. It really took away the panic. It was amazing. I definitely won't need any benzos now.<grinnage>
> Are there any contraindications or drug interactions with this that you know of?
Nope. Toxic effects have never been reported, to my knowledge, at doses less than 3000 mg/day.
> The only downside is that it made me tired.
It does that to me, too. I know I ought to listen to myself more often.....NADH and niacinamide make a nice combination. As do NADH and TMG (trimethylglycine).
> This would be an incredible sleeping pill for me too. I can't tolerate Benadryl but there would be no need to with B3 on hand. I wonder if I drank coffee with it or took a sudafed if that would allow me to feel more awake while also serving as bronchodilators.
Sounds like you have some experiments to do.
> Also, I've read that long-term antihistamine use can cause or worsen depression. I wonder if that would apply to long-term B3 intake?
I wouldn't worry about it. If you keep your approach to self-treatment intuitive and symptom-driven, I think you just learn how to deal.
> Thanks so much for suggesting this to me!
>
> KYou're very welcome. And thanks for affirming that my advice is sometimes helpful.
Lar
Posted by KaraS on December 12, 2004, at 14:21:53
In reply to Re: WOW! Niacinamide really works! » KaraS, posted by Larry Hoover on December 12, 2004, at 10:34:10
> > > > > The niacinamide is within twenty minutes.
> >
> > I only took 250 mg. and it really calmed me down while making it easier to breathe. It really took away the panic. It was amazing. I definitely won't need any benzos now.
>
> <grinnage>
>
> > Are there any contraindications or drug interactions with this that you know of?
>
> Nope. Toxic effects have never been reported, to my knowledge, at doses less than 3000 mg/day.
>
I wonder if it would be a problem to take this with an MAOI or close in time to an MAOI. Some antihistamines can't be taken with them, can they? ... or is it just the decongestants?> > The only downside is that it made me tired.
>
> It does that to me, too. I know I ought to listen to myself more often.....NADH and niacinamide make a nice combination. As do NADH and TMG (trimethylglycine).So the NADH counters the tiredness you feel from the niacinamide? I tried NADH but it didn't give me any energy or stimulation. (That darn malfunctioning dopamine system of mine - notice I didn't say hypersensitive autoreceptors?) :-)
> > This would be an incredible sleeping pill for me too. I can't tolerate Benadryl but there would be no need to with B3 on hand. I wonder if I drank coffee with it or took a sudafed if that would allow me to feel more awake while also serving as bronchodilators.
>
> Sounds like you have some experiments to do.Definitely, now that i know that it's safe to do.
> > Also, I've read that long-term antihistamine use can cause or worsen depression. I wonder if that would apply to long-term B3 intake?
>
> I wouldn't worry about it. If you keep your approach to self-treatment intuitive and symptom-driven, I think you just learn how to deal.Ok, I'll buy that.
>
> > Thanks so much for suggesting this to me!
> >
> > K
>
> You're very welcome. And thanks for affirming that my advice is sometimes helpful.
>
> Lar
Well, we don't call you "Hoover, Larry Hoover" for nothing!K
Posted by jujube on December 12, 2004, at 15:04:11
In reply to Re: WOW! Niacinamide really works! » KaraS, posted by Larry Hoover on December 12, 2004, at 10:34:10
And thanks for affirming that my advice is sometimes helpful.
>
> Lar- Your advice has certainly always been helpful to me (and, by extension, my family). I now have my anxious, worry-wart mother taking niacinimide (500 mg at day), and she has noticed that she is feeling calmer.
So, gros merci milles fois!
Tamara
Posted by TheOutsider on December 13, 2004, at 16:59:16
In reply to Re: WOW! Niacinamide really works! - for Larry, posted by jujube on December 12, 2004, at 15:04:11
What brand of Niacinamide are you using?
I find brand is often half the battle with supplements!
Posted by KaraS on December 14, 2004, at 21:26:45
In reply to Re: WOW! Niacinamide really works! » KaraS, posted by Larry Hoover on December 12, 2004, at 10:34:10
My friend too 400 mg. of this last night for sleep and she said it helped immensely. As this as good as niacinamide? Are there any problems with taking it every night?
Posted by Larry Hoover on December 18, 2004, at 10:36:40
In reply to Re: WOW! Niacinamide really works! » Larry Hoover, posted by KaraS on December 12, 2004, at 14:21:53
> > > Are there any contraindications or drug interactions with this that you know of?
> >
> > Nope. Toxic effects have never been reported, to my knowledge, at doses less than 3000 mg/day.
> >
>
>
> I wonder if it would be a problem to take this with an MAOI or close in time to an MAOI. Some antihistamines can't be taken with them, can they? ... or is it just the decongestants?Different rationale. It's the nonspecific activity of the older antihistamine/decongestants that's the problem.
>
> > > The only downside is that it made me tired.
> >
> > It does that to me, too. I know I ought to listen to myself more often.....NADH and niacinamide make a nice combination. As do NADH and TMG (trimethylglycine).
>
> So the NADH counters the tiredness you feel from the niacinamide? I tried NADH but it didn't give me any energy or stimulation. (That darn malfunctioning dopamine system of mine - notice I didn't say hypersensitive autoreceptors?) :-)They seemed to work well together, in this particular body.
> Well, we don't call you "Hoover, Larry Hoover" for nothing!
>
> KFunny, I thought that was speech impediment, and I didn't want to draw attention to it.
Lar
Posted by Larry Hoover on December 18, 2004, at 10:37:55
In reply to Re: WOW! Niacinamide really works! - for Larry, posted by jujube on December 12, 2004, at 15:04:11
> And thanks for affirming that my advice is sometimes helpful.
> >
> > Lar
>
> - Your advice has certainly always been helpful to me (and, by extension, my family). I now have my anxious, worry-wart mother taking niacinimide (500 mg at day), and she has noticed that she is feeling calmer.
>
> So, gros merci milles fois!
>
> TamaraI'm very glad. There is a special kind of empowerment that comes from taking control of what you consume.
Lar
Posted by Larry Hoover on December 18, 2004, at 10:40:27
In reply to Re: flush-free niacin (as inositol hexanicotinate) » Larry Hoover, posted by KaraS on December 14, 2004, at 21:26:45
> My friend too 400 mg. of this last night for sleep and she said it helped immensely. As this as good as niacinamide? Are there any problems with taking it every night?
As far as I know, there is virtually zero risk from this. This formulation avoids the niacin flush because the ester bonds between the nicotinic acid and the inositol are rather slowly broken. This permits the formation of niacinamide from the niacin, like a sustained release niacinamide tablet might.
Lar
Posted by KaraS on December 18, 2004, at 17:05:22
In reply to Re: WOW! Niacinamide really works! » KaraS, posted by Larry Hoover on December 18, 2004, at 10:36:40
> > I wonder if it would be a problem to take this with an MAOI or close in time to an MAOI. Some antihistamines can't be taken with them, can they? ... or is it just the decongestants?
> Different rationale. It's the nonspecific activity of the older antihistamine/decongestants that's the problem.
The niacinamide is very specific then, and perfectly safe to combine? (I just want to make sure I understand completely in this case.)
> > Well, we don't call you "Hoover, Larry Hoover" for nothing!
> >
> > K
>
> Funny, I thought that was speech impediment, and I didn't want to draw attention to it.:-)
K
Posted by PeterJ on December 22, 2004, at 0:01:27
In reply to Re: WOW! Niacinamide really works! » Larry Hoover, posted by KaraS on December 12, 2004, at 1:31:01
> I only took 250 mg. and it really calmed me down while making it easier to breathe. It really took away the panic. It was amazing. I definitely won't need any benzos now. Are there any contraindications or drug interactions with this that you know of?
I haven't noticed it mentioned, but niacinamide binds to the benzodiazepine receptor, so it is a bit like taking a low potency natural benzodiazepine. I have found it a good anxiolytic in the past. The only drawback I found is that tolerance may develop. But I don't recall any withdrawal effects.
There is some theoretical concern because niacinamide can acclerate aging in some lower animals, but this is only shown in worms and such, and there is no evidence this occurs in humans.
All in all, it's probably better than a benzo if it works for you.
PeterJ
Posted by KaraS on December 22, 2004, at 23:32:53
In reply to Re: WOW! Niacinamide really works!, posted by PeterJ on December 22, 2004, at 0:01:27
> > I only took 250 mg. and it really calmed me down while making it easier to breathe. It really took away the panic. It was amazing. I definitely won't need any benzos now. Are there any contraindications or drug interactions with this that you know of?
>
> I haven't noticed it mentioned, but niacinamide binds to the benzodiazepine receptor, so it is a bit like taking a low potency natural benzodiazepine. I have found it a good anxiolytic in the past. The only drawback I found is that tolerance may develop. But I don't recall any withdrawal effects.
> There is some theoretical concern because niacinamide can acclerate aging in some lower animals, but this is only shown in worms and such, and there is no evidence this occurs in humans.
> All in all, it's probably better than a benzo if it works for you.
> PeterJ
>Thanks. It's only a short-term solution for me so I think it should be fine. That's a little scary about those worms though.
K
Posted by KaraS on December 23, 2004, at 23:06:59
In reply to Re: WOW! Niacinamide really works! » KaraS, posted by Larry Hoover on December 12, 2004, at 10:34:10
Larry,
I wasn't clear as to whether you were saying that niacinamide could be taken with an MAOI or not. I think you were inferring that it could be but I wanted to make absolutely sure in this case.
The niacinamide is still working really well for me. After the first couple of days where it would wear off in a few hours, now it seems to linger for quite a while. I found the dose that keeps me calm enough and yet allows me some cognitive functioning. It's between 1/3 - 1/4 of a 500 mg. capsule and I take it twice a day. It gives me continuous coverage without any rebound anxiety. It's really a huge help for the time being. The anxiety is at least 90% under control now and I can function at the temporary jobs.
Speaking of cognitive functioning, do you notice the anticholinergic effects of the trimipramine negatively impacting your cognitive functioning? I used to feel that the low dose doxepin, and to a lesser extent maprotiline, that I took for sleep, did make it harder to concentrate. I wonder why you decided on trimipramine rather than doxepin or maprotiline to help you sleep since I think that both of them are supposed to be less anticholinergic?
K
Posted by Larry Hoover on December 24, 2004, at 9:28:21
In reply to Re: More Niacinamide questions » Larry Hoover, posted by KaraS on December 23, 2004, at 23:06:59
> Larry,
>
> I wasn't clear as to whether you were saying that niacinamide could be taken with an MAOI or not. I think you were inferring that it could be but I wanted to make absolutely sure in this case.I can't think of a single reason why there should be any problem combining them.
> The niacinamide is still working really well for me. After the first couple of days where it would wear off in a few hours, now it seems to linger for quite a while. I found the dose that keeps me calm enough and yet allows me some cognitive functioning. It's between 1/3 - 1/4 of a 500 mg. capsule and I take it twice a day. It gives me continuous coverage without any rebound anxiety. It's really a huge help for the time being. The anxiety is at least 90% under control now and I can function at the temporary jobs.
I'm so very glad. That is a Christmas gift, hearing the good news.
> Speaking of cognitive functioning, do you notice the anticholinergic effects of the trimipramine negatively impacting your cognitive functioning? I used to feel that the low dose doxepin, and to a lesser extent maprotiline, that I took for sleep, did make it harder to concentrate. I wonder why you decided on trimipramine rather than doxepin or maprotiline to help you sleep since I think that both of them are supposed to be less anticholinergic?
>
> KIt's kind of a fluke, and kind of an experimental outcome.
When I went to my family doctor seeking a histaminergic sleep augmentative med, I presented a list of the three most histaminergic tricyclics (doxepin, trimipramine, amitryptiline), and basically said, "Pick one, but don't pick amitryptiline." He confused doxepin for a different drug, so I ended up with trimipramine. This was added to Zoloft, at the time. It seemed to be losing efficacy, even at 50 mg, but I found the anticholinergic aspects too strong at 50 mg, so a dose increase was out of the question. At that point, my doc allowed a trial of doxepin (apparently, the confusion had disappeared by then). Despite its stronger histaminergic activity, it worked less well than did the trimipramine, so I switched back. At this point, I had withdrawn from Zoloft, and I'm back at 25 mg trimip.
I didn't even consider maprotiline. What is its claim to fame? Doesn't it have a very long half-life?
Lar
Posted by KaraS on December 24, 2004, at 13:16:52
In reply to Re: More Niacinamide questions » KaraS, posted by Larry Hoover on December 24, 2004, at 9:28:21
> > Larry,
> >
> > I wasn't clear as to whether you were saying that niacinamide could be taken with an MAOI or not. I think you were inferring that it could be but I wanted to make absolutely sure in this case.
>
> I can't think of a single reason why there should be any problem combining them.Great!
> > The niacinamide is still working really well for me. After the first couple of days where it would wear off in a few hours, now it seems to linger for quite a while. I found the dose that keeps me calm enough and yet allows me some cognitive functioning. It's between 1/3 - 1/4 of a 500 mg. capsule and I take it twice a day. It gives me continuous coverage without any rebound anxiety. It's really a huge help for the time being. The anxiety is at least 90% under control now and I can function at the temporary jobs.
>
> I'm so very glad. That is a Christmas gift, hearing the good news.
Thanks. That's very sweet of you to say.>
> > Speaking of cognitive functioning, do you notice the anticholinergic effects of the trimipramine negatively impacting your cognitive functioning? I used to feel that the low dose doxepin, and to a lesser extent maprotiline, that I took for sleep, did make it harder to concentrate. I wonder why you decided on trimipramine rather than doxepin or maprotiline to help you sleep since I think that both of them are supposed to be less anticholinergic?
> >
> > K
>
> It's kind of a fluke, and kind of an experimental outcome.
>
> When I went to my family doctor seeking a histaminergic sleep augmentative med, I presented a list of the three most histaminergic tricyclics (doxepin, trimipramine, amitryptiline), and basically said, "Pick one, but don't pick amitryptiline." He confused doxepin for a different drug, so I ended up with trimipramine. This was added to Zoloft, at the time. It seemed to be losing efficacy, even at 50 mg, but I found the anticholinergic aspects too strong at 50 mg, so a dose increase was out of the question. At that point, my doc allowed a trial of doxepin (apparently, the confusion had disappeared by then). Despite its stronger histaminergic activity, it worked less well than did the trimipramine, so I switched back. At this point, I had withdrawn from Zoloft, and I'm back at 25 mg trimip.
>
> I didn't even consider maprotiline. What is its claim to fame? Doesn't it have a very long half-life?
>
> LarI didn't realize that it's half-life was that long but it didn't really adversely affect me. I thought that MAP was one of the most anithistaminic of the sedating TCAs and yet less anticholinergic. I used to take doxepin for years for sleep but then I switched to MAP. MAP was much better for me. I didn't feel as much of a groggy hangover in the morning. It may be too subtle for your sleep problems though.
K
Posted by KaraS on December 29, 2004, at 17:38:18
In reply to Re: More Niacinamide questions » KaraS, posted by Larry Hoover on December 24, 2004, at 9:28:21
A friend of mine has Parkinson's. She is looking for something to help her sleep. I suggested B3 but I wanted to make sure that it's not contraindicated with any of her other medications. She takes Requipt, L-Dopa and selegiline. She used to take Benedryl but then read about it not being good for you to take long-term - esp. if you have Parkinson's. Can you shed any light here?
Thanks,
K
Posted by Larry Hoover on December 30, 2004, at 12:48:37
In reply to Re: Niacinamide ok if you're on Parkinson's meds? » Larry Hoover, posted by KaraS on December 29, 2004, at 17:38:18
> A friend of mine has Parkinson's. She is looking for something to help her sleep. I suggested B3 but I wanted to make sure that it's not contraindicated with any of her other medications. She takes Requipt, L-Dopa and selegiline. She used to take Benedryl but then read about it not being good for you to take long-term - esp. if you have Parkinson's. Can you shed any light here?
>
> Thanks,
> KActually, I would think Benadryl might have adverse effects...
Anyway, I am pleased to report that niacinamide may even be an effective adjunctive treatment for Parkinson's. Picamilon is supposed to be very helpful, too.
Ann Neurol. 2003;53 Suppl 3:S39-47; discussion S47-8.
Bioenergetic approaches for neuroprotection in Parkinson's disease.Beal MF.
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA. fbeal@mail.med.cornell.edu
There is considerable evidence suggesting that mitochondrial dysfunction and oxidative damage may play a role in the pathogenesis of Parkinson's disease (PD). This possibility has been strengthened by recent studies in animal models, which have shown that a selective inhibitor of complex I of the electron transport gene can produce an animal model that closely mimics both the biochemical and histopathological findings of PD. Several agents are available that can modulate cellular energy metabolism and that may exert antioxidative effects. There is substantial evidence that mitochondria are a major source of free radicals within the cell. These appear to be produced at both the iron-sulfur clusters of complex I as well as the ubiquinone site. Agents that have shown to be beneficial in animal models of PD include creatine, coenzyme Q(10), Ginkgo biloba, nicotinamide, and acetyl-L-carnitine. Creatine has been shown to be effective in several animal models of neurodegenerative diseases and currently is being evaluated in early stage trials in PD. Similarly, coenzyme Q(10) is also effective in animal models and has shown promising effects both in clinical trials of PD as well as in clinical trials in Huntington's disease and Friedreich's ataxia. Many other agents show good human tolerability. These agents therefore are promising candidates for further study as neuroprotective agents in PD.
Lar
This is the end of the thread.
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