Psycho-Babble Medication Thread 1113790

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by mogger on February 18, 2021, at 0:52:17

Has anyone had experience with these three with these conditions?

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by undopaminergic on February 18, 2021, at 4:44:09

In reply to Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep, posted by mogger on February 18, 2021, at 0:52:17

> Has anyone had experience with these three with these conditions?

I've tried all but Caplyta. Possibly cariprazine had a minor stimulant effect, and if so, it was better at 1.5 mg than 3.0.

I'm currently on lurasidone (Latuda), and I think it is the most antidepressive antipsychotic I've tried, except for a powerful but temporary stimulant effect of sulpiride when I first tried it.

-undopaminergic

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by Lamdage22 on February 18, 2021, at 7:20:21

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep, posted by undopaminergic on February 18, 2021, at 4:44:09

Zyprexa is good for anxiety. When I was taken off and put back on, it felt like a protective coat. Less anxiety!

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by Christ_empowered on February 18, 2021, at 8:26:41

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep, posted by Lamdage22 on February 18, 2021, at 7:20:21

very low dose (2.5 mgs, if I recall correctly) zyprexa helped anxiety and agitation...a lot. then I went to 5mgs, and had akathisia. -ugh-

abilify is OK. I take 20mgs. doesn't make mood worse, takes the edge off depressive lows (less agitation, for instance). akathisia is more common with abilify than with zyprexa, but I've read (and been told) that people who can tolerate Abilify generally prefer it to other antipsychotics.

i don't have personal experience with vraylar, sorry. a psych brought it up...and it sounded scary. apparently, there's not as much D2 partial agonism going on with Vraylar, which the psych tried to sell as a good thing...

but i was concerned about dysphoria, depression, TD, etc.

caplyta i also have 0 experience with, sorry. it is very new, i think it has a somewhat unique mechanism of action (?), so..???

wish i could have offered more help. i will say that although doctors are forever pushing low(ish) doses of abilify on people for depression, what little i"ve read on the subject makes it seem...

well, it doesn't seem like the best maneuver, ever. high costs, in the aggregate the benefits aren't tremendous, plus that means non-psychotic disorder individuals get exposed to neuroleptics (always a risky thing, honestly).

random question...are you on an antidepressant, now? has your psych considered buspar augmentation?

ok. :-)

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by rjlockhart37 on February 19, 2021, at 13:49:11

In reply to Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep, posted by mogger on February 18, 2021, at 0:52:17

i found abilify stimuating, but i was only on it for 2 weeks. It made me feel kinda irregular. Zyprexa is sedating, but it gets rid of anxiety very well. I've been on it for 11 years and ... it kinda lost it's effect but if don't take it for long time, then take it again i feel the antianxiety effect

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep » undopaminergic

Posted by SLS on February 21, 2021, at 21:54:16

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep, posted by undopaminergic on February 18, 2021, at 4:44:09

>
> I'm currently on lurasidone (Latuda), and I think it is the most antidepressive antipsychotic I've tried, except for a powerful but temporary stimulant effect of sulpiride when I first tried it.
>
> -undopaminergic
>

Great news, UD!

I just responded to your post to me up a bit on the board. From what I've heard from psychiatrists, Latuda is the best antipsychotic weapon in the treatment of bipolar depression - even better than Abilify. The medical literature regarding lurasodone is reason for optimism.


https://pubmed.ncbi.nlm.nih.gov/?term=lurasidone+bipolar&sort=date&size=50


- Scott

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by mogger on February 22, 2021, at 7:46:11

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep » undopaminergic, posted by SLS on February 21, 2021, at 21:54:16

That is so awesome about latuda. I took it and for a weeks it had pronounced ad effects until I could sleep and developed akathesia so had to discontinue. I agree about the early sentiment about zyprexa as I am on it and it does wonders for anxiety. Looking for a depression boost. I am on 120mgs of buspar, twice the maximum dose. It helps too. Many thanks for all your replies.

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep » SLS

Posted by undopaminergic on February 22, 2021, at 8:41:46

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep » undopaminergic, posted by SLS on February 21, 2021, at 21:54:16

> >
> > I'm currently on lurasidone (Latuda), and I think it is the most antidepressive antipsychotic I've tried, except for a powerful but temporary stimulant effect of sulpiride when I first tried it.
> >
> > -undopaminergic
> >
>
> Great news, UD!
>
> I just responded to your post to me up a bit on the board. From what I've heard from psychiatrists, Latuda is the best antipsychotic weapon in the treatment of bipolar depression - even better than Abilify. The medical literature regarding lurasodone is reason for optimism.
>
>
> https://pubmed.ncbi.nlm.nih.gov/?term=lurasidone+bipolar&sort=date&size=50
>
>
> - Scott

I've read some of the abstracts, and I found this one a bit odd:
https://pubmed.ncbi.nlm.nih.gov/32827348/

Namely, 20-60 mg of lurasidone was more effective than 80-120 mg. Should I be glad I'm not on more than 74 mg?

-undopaminergic

 

Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by undopaminergic on February 22, 2021, at 10:35:52

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep » SLS, posted by undopaminergic on February 22, 2021, at 8:41:46

> >
> > I just responded to your post to me up a bit on the board. From what I've heard from psychiatrists, Latuda is the best antipsychotic weapon in the treatment of bipolar depression - even better than Abilify. The medical literature regarding lurasodone is reason for optimism.
> >
> >
> > https://pubmed.ncbi.nlm.nih.gov/?term=lurasidone+bipolar&sort=date&size=50
> >
> >
> > - Scott
>
> I've read some of the abstracts, and I found this one a bit odd:
> https://pubmed.ncbi.nlm.nih.gov/32827348/
>
> Namely, 20-60 mg of lurasidone was more effective than 80-120 mg. Should I be glad I'm not on more than 74 mg?
>
> -undopaminergic
>

This may shed some light on it:
https://sci-hub.se/https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1695777

In short: the serotonin 5-HT7-antagonism is achieved at lower doses than the dopamine D2-antagonism, and this may be responsible for the antidepressant (as opposed to the antipsychotic) effect. Meanwhile, with much higher doses, the D2-antagonism can reach levels that may produce dysphoric effects.

-undopaminergic


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