Psycho-Babble Medication Thread 1113160

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Testosterone nasal spray for anxiety

Posted by Hugh on December 30, 2020, at 13:24:29

A testosterone-containing nasal spray received its second U.S. patent and its first patent in Europe, making it the first testosterone therapy licensed to treat anxiety disorders.

Although testosterone therapy is most often marketed and prescribed to men suffering from "low T"--testosterone deficiency or hypogonadism--researchers with The University of Texas at Austin and MedCara Pharmaceuticals developed a nasal spray in response to a long-standing research question about why women are twice as likely as men to develop anxiety disorders.

"A growing body of research points to testosterone's importance in the etiology of anxiety disorders," said Robert Josephs, a professor of psychology at UT Austin who along with MedCara pharmacist Craig Herman developed the spray.

Research has shown that although there is no difference in anxiety disorders among prepubescents, puberty introduces a sharp uptick in anxiety disorders in girls, who naturally have about one-tenth the amount of testosterone as boys. The researchers speculated that men's higher concentrations of circulating testosterone may protect against anxiety and began developing a treatment to address the issue.

"With this second U.S. patent and a first European patent supporting these claims, we're one step closer to introducing a new weapon in the ongoing battle against mental illness," said Josephs, who is also an adjunct professor of psychiatry in UT Austin's Dell Medical School.

The first patent for his invention was issued in April 2019, with broad claims as a treatment option for fear-based disorders. This second U.S. patent, however, has the power to change the way testosterone therapy is used and how anxiety disorders are treated.

Although testosterone is not currently prescribed for anxiety, Josephs hopes that a short-term, fast-acting testosterone product might be prescribed alongside a lower dosage of benzodiazepines--such as Xanax or Klonopin--for treating anxiety disorders such as PTSD and OCD.

"Although benzodiazepines work well, they have strong sedative effects," Josephs said. "Testosterone is not sedating."

The aqueous-based nasal spray also addresses a current market need for comfortable, controlled, and fast-acting dosages of testosterone for people struggling with "low T" or a decreased libido. Traditional testosterone supplements, including drops, transdermal creams and gels, injections and subcutaneous "seeds," can take days and/or multiple doses to reach full potential. Testosterone is in high demand, with prescriptions increasing fivefold since 2011.

The nasal spray (U.S. Patent No. 10,258,63, issued April 16, 2019; U.S. Patent No. 10,751,348, issued Aug. 25, 2020) has been licensed to Acerus Pharmaceuticals Corporation, which has the flexibility under the current agreement to use the technology in whatever medical field it deems most appropriate.

A Chinese patent is also forthcoming, paving the way for the psychology professor's invention to be available worldwide.

 

Re: Testosterone nasal spray for anxiety

Posted by Lamdage22 on December 30, 2020, at 14:12:40

In reply to Testosterone nasal spray for anxiety, posted by Hugh on December 30, 2020, at 13:24:29

Yep, some people on this board might improve on it. Been saying it.

 

Re: Testosterone nasal spray for anxiety

Posted by undopaminergic on December 31, 2020, at 9:29:00

In reply to Re: Testosterone nasal spray for anxiety, posted by Lamdage22 on December 30, 2020, at 14:12:40

> Yep, some people on this board might improve on it. Been saying it.

I had relatively severe, persistent acne, which suggests I had high testosterone (TS). Also, I have partially feminised hips, probably from estradiol, which is synthesised from testosterone.

But now, my sex drive is asleep, which may suggest I now have low TS.

-undopaminergic

 

Re: Testosterone nasal spray for anxiety undopaminergic

Posted by Hugh on December 31, 2020, at 16:20:49

In reply to Re: Testosterone nasal spray for anxiety, posted by undopaminergic on December 31, 2020, at 9:29:00

Arimidex will get estradiol levels way down, even too low if you take too much. It's a breast cancer drug, but bodybuilders take a much lower dose -- 0.25 or 0.5 mg, two or three times a week -- to get their estrogen down and their free testosterone up. If your estradiol level is fine, the beta-blocker nebivolol causes a significant increase in testosterone.

 

Re: Testosterone nasal spray for anxiety

Posted by beckett2 on December 31, 2020, at 18:46:12

In reply to Testosterone nasal spray for anxiety, posted by Hugh on December 30, 2020, at 13:24:29

Interesting. I imagine best used in conjunction w an endocrinologist onboard somewhere?

A woman I knew had testosterone treatment (for something) and said she felt SO good. She drove w/o fear, not realizing how anxious she had been before. Temporary of course.

 

Re: Testosterone nasal spray for anxiety

Posted by Lamdage22 on January 1, 2021, at 1:21:59

In reply to Testosterone nasal spray for anxiety, posted by Hugh on December 30, 2020, at 13:24:29

If you are deficient in Testosterone, supplementing it can make a world of a difference. That is what I heard. The older you are, the more likely you are deficient. I suspect that the Testosterone is absorbed into the bloodstream if you spray it into your nose. So yeah, a Testosterone test might be a good investment if you are 50 or older.

 

Re: Testosterone nasal spray for anxiety

Posted by Lamdage22 on January 1, 2021, at 1:37:59

In reply to Re: Testosterone nasal spray for anxiety, posted by Lamdage22 on January 1, 2021, at 1:21:59

If you are depressed because you are deficient in nutrients or hormones, I think that taking meds only masks the problem in the best case scenario and you are susceptible for poop out. It is a possibility that should be ruled out. Unless of course you are violently psychotic or so suicidal that it is an emergency. Then, but only then I would give meds immediately and figure out deficiencies afterwards.

 

Re: Testosterone nasal spray for anxiety

Posted by linkadge on January 1, 2021, at 10:15:29

In reply to Re: Testosterone nasal spray for anxiety, posted by Lamdage22 on January 1, 2021, at 1:37:59

People whose depression is caused by low testosterone would likely fare poorly on SSRIs. I see SSRIs as somewhat feminizing in themselves.

I believe that testosterone has more of an impact on dopamine than serotonin.

Linkadge

 

Re: Testosterone nasal spray for anxiety

Posted by Lamdage22 on January 1, 2021, at 10:30:20

In reply to Re: Testosterone nasal spray for anxiety, posted by linkadge on January 1, 2021, at 10:15:29

I had lower than average levels but still well in the healthy range. I got no signs of low testosterone whatsoever other than low mood. So I take it that I'm okay. Sex drive, muscle growth and voice and body hair, all good. So I'm not sacrificing my natural T producton or ability to get children. You never know. Maybe it turns out my mental health issues were not genetic but situational. The lower T could be a result of Metformin. It is known to lower testosterone. But it helps me to not get severely overweight so I am not dropping it.

If you are not the youngest anymore and especially if you show signs of low T then maybe you should get tested. Maybe insurance will pay. Negotiate! But know that you may not be able to get children again and don't crush an ok testosterone production just because you are a bit below average.

It strikes me as odd that nobody thought of a testosterone nasal spray before! Gel is inconvenient and messy.

 

Re: Testosterone nasal spray for anxiety

Posted by Hugh on January 3, 2021, at 11:32:56

In reply to Re: Testosterone nasal spray for anxiety undopaminergic, posted by Hugh on December 31, 2020, at 16:20:49

Here's an excellent article about testosterone, which includes information about estrogen levels, vitamin D levels, and aromatase:

https://www.lifeextension.com/magazine/2012/6/testosterone-controversy

 

Re: Testosterone nasal spray for anxiety

Posted by Lamdage22 on January 4, 2021, at 3:00:25

In reply to Re: Testosterone nasal spray for anxiety, posted by Hugh on January 3, 2021, at 11:32:56

Interesting. However, they do not talk about shutdown of natural production and infertility associated with Tesotosterone replacement.

> Here's an excellent article about testosterone, which includes information about estrogen levels, vitamin D levels, and aromatase:
>
> https://www.lifeextension.com/magazine/2012/6/testosterone-controversy

 

Magnesium appears to raise Testosterone

Posted by Lamdage22 on January 20, 2021, at 10:09:43

In reply to Re: Testosterone nasal spray for anxiety, posted by Lamdage22 on January 4, 2021, at 3:00:25

I came across this in a bodybuilding forum. https://pubmed.ncbi.nlm.nih.gov/20352370/

Also I am looking into fenugreek and stinging nettle.


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