Shown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Skeletor on November 30, 2020, at 15:37:42
For example Desipramine, Reboxetine, Bupropion, Nortriptyline, Atomoxetine, Methylphenidiat, Amphetamines...
Will they exacerbate obsessive and compulsive tendencies?
Posted by linkadge on November 30, 2020, at 17:08:50
In reply to Do NRIs and Stimulants make OCD worse?, posted by Skeletor on November 30, 2020, at 15:37:42
Not necessarily. There is some genetic link between OCD and ADHD. In recent genetic studies it was shown that there was some overlap in the genes for the two. I know that stimulants have sometimes been used successfully as adjuncts to SSRIs for OCD.
Of course could, but you'd have to try and see. I think the amphetamines would be (possibly) less likely to induce OCD as they have serotonergic mechanisms as well.
Linkadge
Posted by undopaminergic on December 1, 2020, at 10:38:46
In reply to Re: Do NRIs and Stimulants make OCD worse?, posted by linkadge on November 30, 2020, at 17:08:50
> Not necessarily.
Right. For me, most of the time, ethylphenidate (almost exactly the same as methylphenidate) did not provoke OCD symptoms, but on occasion, it gave me pretty much the only OCD behaviour I've experienced in life. So, yes, they can, but usually don't. Obviously, some people are particularly sensitive to this effect.
-undopaminergic
Posted by undopaminergic on December 1, 2020, at 10:45:12
In reply to Re: Do NRIs and Stimulants make OCD worse?, posted by undopaminergic on December 1, 2020, at 10:38:46
> > Not necessarily.
>
> Right. For me, most of the time, ethylphenidate (almost exactly the same as methylphenidate) did not provoke OCD symptoms, but on occasion, it gave me pretty much the only OCD behaviour I've experienced in life. So, yes, they can, but usually don't. Obviously, some people are particularly sensitive to this effect.
>
> -undopaminergic
>^ Stimulants, that is. I don't know about selective NRIs, but I don't think so.
-undopaminergic
Posted by jay2112 on December 4, 2020, at 2:52:31
In reply to Do NRIs and Stimulants make OCD worse?, posted by Skeletor on November 30, 2020, at 15:37:42
> For example Desipramine, Reboxetine, Bupropion, Nortriptyline, Atomoxetine, Methylphenidiat, Amphetamines...
>
> Will they exacerbate obsessive and compulsive tendencies?
Well, stimulants in particular, most likely not. Because, the opposite of stimulants, antipsychotics, DO make OCD worse.
Posted by undopaminergic on December 4, 2020, at 3:00:29
In reply to Re: Do NRIs and Stimulants make OCD worse? » Skeletor, posted by jay2112 on December 4, 2020, at 2:52:31
> > For example Desipramine, Reboxetine, Bupropion, Nortriptyline, Atomoxetine, Methylphenidiat, Amphetamines...
> >
> > Will they exacerbate obsessive and compulsive tendencies?
>
>
> Well, stimulants in particular, most likely not. Because, the opposite of stimulants, antipsychotics, DO make OCD worse.
>That is interesting, because antipsychotics are not infrequently used to treat OCD. Perhaps it is a matter of imbalance, too high or too low dopamine.
-undopaminergic
Posted by Lamdage22 on December 4, 2020, at 3:52:05
In reply to Re: Do NRIs and Stimulants make OCD worse? » Skeletor, posted by jay2112 on December 4, 2020, at 2:52:31
Exactly. They do.
> Well, stimulants in particular, most likely not. Because, the opposite of stimulants, antipsychotics, DO make OCD worse.
Posted by Christ_empowered on December 4, 2020, at 15:33:28
In reply to Re: Do NRIs and Stimulants make OCD worse?, posted by undopaminergic on December 4, 2020, at 3:00:29
benzodiazepines and stimulants seem to be fairly commonly used in ocd. as with many (all?) other psychiatric diagnoses, there seems to be something of a 'spectrum' of people, problems that end up with the same overall label.
not to go all marxist on this, but i think social class plays a role in treatment, too. any medical treatment, but...whoa...definitely mental health treatment. if you have to go to a community clinic, it'll probably involve an antipsychotic. they give everyone antipsychotics, its in their job description.
with insurance and a private practice shrink, maybe a benzodiazepine. maybe not. even with insurance, some people/patients are "good enough" for mother's little helpers, others...get high dose ssri drugs, maybe some buspar.
and then the cash only, no insurance doctors. never gone to one myself, but the impression i get is...well, within reason, ask and ye shall receive. i mean, nothing that would put the prescriber's license in jeopardy (unless you're an attractive female...local case on this recently, soap opera material), but in general...
the private practice insurance shrink will at least think about a controlled substance, maybe prescribe if you're 'good enough,' then the no insurance private pay doctor will probably provide, as long as you're not obviously drug seeking and/or putting them in a position of potential liability and/or push it too far.
so...which drugs/meds 'help' ? considering that the long term adverse effects of the neuroleptics can be horrendous, id say...not those, not really. ssri? yes, largely by reducing frontal lobe activity and inducing a degree of apathy and indifference, but not with as much risk as the tranquilizers. the uppers? possibly. brighter mood, better ability to stay on task, a quick fix to lethargy and anhedonia from other treatments and/or...life...
Posted by Skeletor on December 12, 2020, at 10:21:56
In reply to Re: Do NRIs and Stimulants make OCD worse?, posted by linkadge on November 30, 2020, at 17:08:50
> Not necessarily. There is some genetic link between OCD and ADHD. In recent genetic studies it was shown that there was some overlap in the genes for the two. I know that stimulants have sometimes been used successfully as adjuncts to SSRIs for OCD.
>
> Of course could, but you'd have to try and see. I think the amphetamines would be (possibly) less likely to induce OCD as they have serotonergic mechanisms as well.
>
>
> LinkadgeOkay, that is interesting. I've always thought that OCD is some form of anxiety disorder, but I suppose it depends on the study...
I have some slight OCDish tendencies and Nortriptyline at higher doses seems to make it worse...
Posted by Skeletor on December 12, 2020, at 10:24:49
In reply to Re: Do NRIs and Stimulants make OCD worse?, posted by undopaminergic on December 1, 2020, at 10:38:46
> > Not necessarily.
>
> Right. For me, most of the time, ethylphenidate (almost exactly the same as methylphenidate) did not provoke OCD symptoms, but on occasion, it gave me pretty much the only OCD behaviour I've experienced in life. So, yes, they can, but usually don't. Obviously, some people are particularly sensitive to this effect.
>
> -undopaminergic
>How did you react do SSRIs and NRIs?
Posted by Skeletor on December 12, 2020, at 10:26:35
In reply to Re: Do NRIs and Stimulants make OCD worse? » Skeletor, posted by jay2112 on December 4, 2020, at 2:52:31
> > For example Desipramine, Reboxetine, Bupropion, Nortriptyline, Atomoxetine, Methylphenidiat, Amphetamines...
> >
> > Will they exacerbate obsessive and compulsive tendencies?
>
>
> Well, stimulants in particular, most likely not. Because, the opposite of stimulants, antipsychotics, DO make OCD worse.antipsychotics are used to treat OCD...
Posted by undopaminergic on December 12, 2020, at 10:54:09
In reply to Re: Do NRIs and Stimulants make OCD worse? » undopaminergic, posted by Skeletor on December 12, 2020, at 10:24:49
> > > Not necessarily.
> >
> > Right. For me, most of the time, ethylphenidate (almost exactly the same as methylphenidate) did not provoke OCD symptoms, but on occasion, it gave me pretty much the only OCD behaviour I've experienced in life. So, yes, they can, but usually don't. Obviously, some people are particularly sensitive to this effect.
> >
> > -undopaminergic
> >
>
> How did you react do SSRIs and NRIs?No apparent difference, unless perhaps if you consider the apathy that comes with SSRIs to be, in a way, reduced OCD.
-undopaminergic
Posted by undopaminergic on December 12, 2020, at 10:56:17
In reply to Re: Do NRIs and Stimulants make OCD worse? » jay2112, posted by Skeletor on December 12, 2020, at 10:26:35
> > > For example Desipramine, Reboxetine, Bupropion, Nortriptyline, Atomoxetine, Methylphenidiat, Amphetamines...
> > >
> > > Will they exacerbate obsessive and compulsive tendencies?
> >
> >
> > Well, stimulants in particular, most likely not. Because, the opposite of stimulants, antipsychotics, DO make OCD worse.
>
> antipsychotics are used to treat OCD...That just goes to show how differently different individuals respond to drugs.
-undopaminergic
Posted by Lamdage22 on December 12, 2020, at 13:28:43
In reply to Re: Do NRIs and Stimulants make OCD worse? » Skeletor, posted by undopaminergic on December 12, 2020, at 10:56:17
https://pubmed.ncbi.nlm.nih.gov/25256097/
> Because, the opposite of stimulants, antipsychotics, DO make OCD worse.
> >
> > antipsychotics are used to treat OCD...
>
> That just goes to show how differently different individuals respond to drugs.
>
> -undopaminergic
>
Posted by Skeletor on December 13, 2020, at 6:13:32
In reply to Re: Do NRIs and Stimulants make OCD worse? » Skeletor, posted by undopaminergic on December 12, 2020, at 10:54:09
> > > > Not necessarily.
> > >
> > > Right. For me, most of the time, ethylphenidate (almost exactly the same as methylphenidate) did not provoke OCD symptoms, but on occasion, it gave me pretty much the only OCD behaviour I've experienced in life. So, yes, they can, but usually don't. Obviously, some people are particularly sensitive to this effect.
> > >
> > > -undopaminergic
> > >
> >
> > How did you react do SSRIs and NRIs?
>
> No apparent difference, unless perhaps if you consider the apathy that comes with SSRIs to be, in a way, reduced OCD.
>
> -undopaminergic
>Yeah, that apathy is a pain in the *ss. I had extreme apathy on Sertraline, but doing fairly well on 7.5mg Escitalopram.
This is the end of the thread.
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