Psycho-Babble Medication Thread 1112626

Shown: posts 1 to 3 of 3. This is the beginning of the thread.

 

Histamine H2-receptor antagonism

Posted by undopaminergic on November 19, 2020, at 4:24:14

Hi all,

I was wondering if anyone has any thoughts on or experience with histamine H2-receptor antagonism.

Famotidine has shown promising results in the treatment of negative symptoms in schizophrenia. Negative symptoms are very much like depression, including apathy and anhedonia.

Trimipramine is a potent and high-affinity histamine H2-antagonist. Clozapine is an inverse agonist at the receptor.

In schizohprenia (famotidine):
https://pubmed.ncbi.nlm.nih.gov/23764683/

In depression (ranitidine):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2417877/

-undopaminergic

 

Re: Histamine H2-receptor antagonism

Posted by rjlockhart37 on November 20, 2020, at 14:23:37

In reply to Histamine H2-receptor antagonism, posted by undopaminergic on November 19, 2020, at 4:24:14

not sure if your in us, but zantac the antiacid, heart burn relief, it was removed from the market, i used to live on ranitidine because of excessivee acid burn, it worked so well, and they removed it, i have to stick with pepcid. I didnt really notice any mood improvement, but maybe passively it did and i just didnt notice the antidepressant effect.

I used to live on ranitidine, im serious because of acid issues, they removed it :(

 

Re: Histamine H2-receptor antagonism undopaminergic

Posted by linkadge on November 22, 2020, at 7:45:51

In reply to Histamine H2-receptor antagonism, posted by undopaminergic on November 19, 2020, at 4:24:14

It's hard to gage the effect with a lack of selective & potent (brain penetrant) H2 antagonists. I found famotidine seemed to have a bit of an anti-anxiety effect, but it's hard to tell. Supposedly you need high doses to enter the brain (?)

Linkadge


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.