Psycho-Babble Medication Thread 1112523

Shown: posts 1 to 16 of 16. This is the beginning of the thread.

 

Luvox for COVID

Posted by linkadge on November 12, 2020, at 15:33:25

Apparently the antidepressant luvox (fluvoxamine) has some efficacy in reducing the severity of COVID symptoms. The researchers believed the effect was due to activation of sigma receptors (reducing inflammatory response).


https://medicalxpress.com/news/2020-11-fluvoxamine-illness-covid-patients.html

 

Re: Luvox for COVID linkadge

Posted by Phillipa on November 12, 2020, at 17:43:46

In reply to Luvox for COVID, posted by linkadge on November 12, 2020, at 15:33:25

> Apparently the antidepressant luvox (fluvoxamine) has some efficacy in reducing the severity of COVID symptoms. The researchers believed the effect was due to activation of sigma receptors (reducing inflammatory response).
>
>
> https://medicalxpress.com/news/2020-11-fluvoxamine-illness-covid-patients.html
Link what mg of luvox is required. I still take a small dose of it? Phillipa

 

Re: Luvox for COVID

Posted by Phillipa on November 12, 2020, at 17:51:52

In reply to Re: Luvox for COVID linkadge, posted by Phillipa on November 12, 2020, at 17:43:46

Link another study this is all over the internet. Dose is 100mg TID for 15 days for those at home with mild Covid. See below. Phillipa


https://clinicaltrials.gov/ct2/show/NCT04342663

 

Re: Luvox for COVID

Posted by PeterMartin on November 13, 2020, at 0:19:06

In reply to Re: Luvox for COVID, posted by Phillipa on November 12, 2020, at 17:51:52

I was just reading about this on Reddit. The /r/COVID19 group is fantastic for breakdowns of these pre-prints/new papers. Only science based comments/heavily moderated.

Here's the commentary on this new study:

https://old.reddit.com/r/COVID19/comments/jsy9ya/effect_of_fluvoxamine_vs_placebo_on_clinical/

 

Re: Luvox for COVID

Posted by Phillipa on November 13, 2020, at 8:56:55

In reply to Re: Luvox for COVID, posted by PeterMartin on November 13, 2020, at 0:19:06

My thought thought though is that to give 100mg TID without ever taking this before. How would people tolerate such a high dose when starting dose is 50mg a day? And Maximum dose is really only 250mg a day? Phillipa

 

Re: Luvox for COVID Phillipa

Posted by linkadge on November 14, 2020, at 10:43:59

In reply to Re: Luvox for COVID, posted by Phillipa on November 12, 2020, at 17:51:52

Thanks for sharing.

Linkadge

 

Re: Luvox for COVID linkadge

Posted by Phillipa on November 14, 2020, at 17:30:21

In reply to Re: Luvox for COVID Phillipa, posted by linkadge on November 14, 2020, at 10:43:59

Thanks!

 

Re: Luvox for COVID linkadge

Posted by jay2112 on November 15, 2020, at 1:57:29

In reply to Luvox for COVID, posted by linkadge on November 12, 2020, at 15:33:25

Luvox was my first SSRI, back in 1994. (Yeesshh..I am old..lol) It had some really, spacey-yet-activating, effects, for me anyways.

It has a strong melatonin receptor binding, which seemed to make me feel like I was living in a surreal existence. But, the strong serotonin binding also didn't help me. That was when the whole serotonin-is-god thing was in full-force.

Interesting, and kind-of sad, is that SSRI's taken during pregnancy have shown a co-relation with autism in children. I am not talking about the anti-vaxxer garbage, I mean in the scientific journals: https://www.scientificamerican.com/article/antidepressants-in-pregnancy-tied-to-autism/

Jay

 

Re: Luvox for COVID

Posted by linkadge on November 15, 2020, at 12:55:52

In reply to Re: Luvox for COVID linkadge, posted by jay2112 on November 15, 2020, at 1:57:29

I have, for a long time, believed that psychiatric drug use during pregnancy could be behind the rise in autism incidence. There is no evidence for vaccines causing autism, but there is (as you mention) some evidence that SSRIs increase the risk.

Use of SSRIs (and other antidepressants) skyrocketed during the 90's and 2000's, and many pregnant patients take them under the assumption that they're safe.

As as ide note, newborns experience SSRI withdrawal. I find it infuriating that a mother doesn't want to stop an SSRI because the withdrawal is too difficult, yet have zero problem subjecting their newborn offspring to this horrendous experience as their first experience into the world. Then, of course, not to mention the effects on neurodevelopment, when your synapses are literally forming around floods of serotonin.

Linkadge

 

Re: Luvox for COVID (Maybe Latuda too)

Posted by PeterMartin on November 15, 2020, at 22:56:43

In reply to Re: Luvox for COVID, posted by linkadge on November 15, 2020, at 12:55:52

New pre-print paper out today suggests that Latuda might be able to block COVID19:

https://www.sciencedirect.com/science/article/pii/S0009261420311003?via%3Dihub

Highlights

This paper in-silico identifies multifaceted inhibitors (Lurasidone and Lurasidone exo) for SARS-CoV-2 that can act through the one drug multiple targets strategy.


Molecular Dynamics simulation study reveals a significantly strong binding affinity of Lurasidone and its derivative against multiple SARS-CoV-2 targets namely, main protease, papain-like protease, spike protein, RNA dependent RNA polymerase and helicase.


Lurasidone and Lurasidone exo possess favourable pharmacokinetic properties based on Lipinskis rule, ADMET and target prediction studies.


The unique multitargeting feature of Lurasidone and Lurasidone exo warrants further in-vitro and in-vivo experiments on SARS-CoV-2 for clinical applications.

 

Re: Luvox for COVID (Maybe Latuda too)

Posted by linkadge on November 16, 2020, at 16:28:28

In reply to Re: Luvox for COVID (Maybe Latuda too), posted by PeterMartin on November 15, 2020, at 22:56:43

Interesting.

I know that (pre-covid) certain 5-ht2 blockers have shown an ability to prevent viral entry into the brain.

Linkadge

 

Re: Luvox for COVID (Maybe Latuda too))PeterMartin linkadge

Posted by jay2112 on November 16, 2020, at 18:11:45

In reply to Re: Luvox for COVID (Maybe Latuda too), posted by linkadge on November 16, 2020, at 16:28:28

> Interesting.
>
> I know that (pre-covid) certain 5-ht2 blockers have shown an ability to prevent viral entry into the brain.
>
> Linkadge

Yes, indeed. I am personally extremely responsive to 5ht2 antagonists, and am on Latuda and Risperdal. If nefazadone (Generic Serzone) was available in Canada, I would be on it too. I was on it until it was pulled from the market here (for stupid reasons..it had a small effect on liver enzymes..which could be easily monitored with regular testing)..it has very powerful 5ht2 blocker properties. I think I have some type of mutation or offshoot of Autism..as 5ht2 blockers majorly reduce irritation and frustration in people with Autism. But, I had a lot of developmental problems as a kid. Oddly, stimulants that mostly hit dopamine (Amphetamine..Dexedrine and Vyvanse..Ritalin is too much norepinephrine for me) work amazing for me, too.

Jay

 

Re: Luvox for COVID (Maybe Latuda too))PeterMartin

Posted by undopaminergic on November 17, 2020, at 0:17:45

In reply to Re: Luvox for COVID (Maybe Latuda too))PeterMartin linkadge, posted by jay2112 on November 16, 2020, at 18:11:45

> Oddly, stimulants that mostly hit dopamine (Amphetamine..Dexedrine and Vyvanse..Ritalin is too much norepinephrine for me) work amazing for me, too.
>

From what I can recall, the amphetamines are actually more noradrenergic than methylphenidate.

-undopaminergic

 

Re: Luvox for COVID (Maybe Latuda too))PeterMartin

Posted by linkadge on November 17, 2020, at 14:30:15

In reply to Re: Luvox for COVID (Maybe Latuda too))PeterMartin linkadge, posted by jay2112 on November 16, 2020, at 18:11:45

That is very interesting.

5-ht2 blockers are a lifesaver for me too. They seem to reduce overstimulation and suicidal feelings as well. Off them, I just feel too 'alert' in a way that is hard to describe. It's like a hyper reflection, where I am just too 'self aware'. It becomes very mentally painful and uncomfortable. It's like 'existential' pain. The 5-ht2a blockers just seem to cut this hyper-awareness to the point where I focus on just what is in front of me. Lithium helps a bit with this too, but only in small doses. I also take ritalin which helps, and effexor to a lesser extent. To be honest, I think I would be able to get by without effexor, if I had better anxiety support. The mirtazapine helps some forms of anxiety, but not others. Like yourself, I have often wondered about some form of Autism. I have a lot of niche interests, where I can remember a lot of seemingly useless information. I can go days without any social interaction and feel perfectly fine. I have some social deficits in that I am usually incapable of 'chit chat'. I always want to talk about something big, controversial, or important. I am able to read emotions, but I avoid eye contact at all costs as it is just to painful / intense. The 5-ht2 blockers seem to help the eye contact issue to some extent.

 

Re: Luvox for COVID (Maybe Latuda too))PeterMartin

Posted by linkadge on November 17, 2020, at 14:36:09

In reply to Re: Luvox for COVID (Maybe Latuda too))PeterMartin, posted by undopaminergic on November 17, 2020, at 0:17:45

I have mixed feelings about ritalin. The parent molecule is ~ twice as potent a DRI than a NRI. D-methylphenidate is roughly equipotent.

It does help my concentration and feelings of physical restlessness. However, stimulants in general can be a bit harsh. Sometimes the ups and downs are a bit much.

Linkadge

 

Re: Luvox for COVID

Posted by beckett2 on November 17, 2020, at 22:14:17

In reply to Re: Luvox for COVID, posted by linkadge on November 15, 2020, at 12:55:52

>As as ide note, newborns experience SSRI withdrawal. I find it infuriating that a mother doesn't want to stop an SSRI because the withdrawal is too difficult, yet have zero problem subjecting their newborn offspring to this horrendous experience as their first experience into the world. Then, of course, not to mention the effects on neurodevelopment, when your synapses are literally forming around floods of serotonin.

As a side note to your side note, this withdrawal could easily be dismissed as colic :(


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.