Psycho-Babble Medication Thread 1112475

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Re: Currently on low dose Nortriptyline but not sure..

Posted by undopaminergic on November 9, 2020, at 11:10:39

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 9, 2020, at 10:55:11

>
> Will my teeth rot away due to dry mouth?

It's mainly a matter of acidity. With less saliva to dilute it, it takes longer for the pH to return to neutral after a meal. You can try xylitol.

It's notable that you are experiencing prominent anticholinergic symptoms at such a low dose. But, anticholinergics can be powerful antidepressants, so take it as a promising sign. They say medications without side effects don't work...

-undopaminergic

 

Re: Currently on low dose Nortriptyline but not sure.. undopaminergic

Posted by Skeletor on November 9, 2020, at 11:21:32

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 9, 2020, at 11:10:39

> >
> > Will my teeth rot away due to dry mouth?
>
> It's mainly a matter of acidity. With less saliva to dilute it, it takes longer for the pH to return to neutral after a meal. You can try xylitol.
>
> It's notable that you are experiencing prominent anticholinergic symptoms at such a low dose. But, anticholinergics can be powerful antidepressants, so take it as a promising sign. They say medications without side effects don't work...
>
> -undopaminergic
>

Yeah, having those side effects at only 10mg is really scary... and they say that 50mg is minimum in Depression :D ^^

I probably should test my CYP-450 genes.

I am using xylitol as sugar-replacement and in chewing-gums.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 9, 2020, at 11:23:04

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 9, 2020, at 6:52:49

> >
> > It is my hope that at higher dosages Nortriptyline becomes more pro-noradrenergic and less sedating. H1-saturation and desensitization should occur at fairly low dosages.
> >
>
> Good point. It's worth a try. What's the worst that can happen? Wasting a day sleeping?
>
> -undopaminergic

True.

 

Re: Currently on low dose Nortriptyline but not sure.. Skeletor

Posted by Skeletor on November 9, 2020, at 11:43:29

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 9, 2020, at 10:55:11

(I've been thinking about trying Aripiprazole ("Abilify"), in case Nortriptyline won't work)

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by undopaminergic on November 9, 2020, at 12:29:42

In reply to Re: Currently on low dose Nortriptyline but not sure.. Skeletor, posted by Skeletor on November 9, 2020, at 11:43:29

> (I've been thinking about trying Aripiprazole ("Abilify"), in case Nortriptyline won't work)
>

Probably the only reason aripiprazole sometimes works for depression is that it acts primarily as a dopamine direct agonist at low doses. I strongly recommend you try pramipexole instead, because it acts as an agonist at all doses.

Indeed, pramipexole is the only drug I ever tried that was (temporarily) effective against anhedonia.

-undopaminergic

 

Re: Currently on low dose Nortriptyline but not sure.. undopaminergic

Posted by Skeletor on November 9, 2020, at 12:46:25

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 9, 2020, at 12:29:42

> > (I've been thinking about trying Aripiprazole ("Abilify"), in case Nortriptyline won't work)
> >
>
> Probably the only reason aripiprazole sometimes works for depression is that it acts primarily as a dopamine direct agonist at low doses. I strongly recommend you try pramipexole instead, because it acts as an agonist at all doses.
>
> Indeed, pramipexole is the only drug I ever tried that was (temporarily) effective against anhedonia.
>
> -undopaminergic
>

Pramipexole sure is interesting, but difficult to come by... most doctors especially in Germany are afraid of full dopamine agonists ^^

Imho Aripiprazole is interesting because it is pro-dopaminergic at low dosages (2 mg) and it exhibits 5HT2-antagonist-properties AND it isn't a strong antihistamine. But yeah, your mileage may vary.

Low dosage of Olanzapine is also interesting, but strong antihistamine... ^^

What is your current regimen?

 

Re: Currently on low dose Nortriptyline but not sure.. Skeletor

Posted by ed_uk2010 on November 9, 2020, at 16:09:20

In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10

It's completely normal to feel drowsy when starting nortriptyline, even at low doses.

You're going to have to give it a couple of weeks to see whether it wears off.

 

Re: Currently on low dose Nortriptyline but not sure.. ed_uk2010

Posted by Skeletor on November 9, 2020, at 16:13:00

In reply to Re: Currently on low dose Nortriptyline but not sure.. Skeletor, posted by ed_uk2010 on November 9, 2020, at 16:09:20

> It's completely normal to feel drowsy when starting nortriptyline, even at low doses.
>
> You're going to have to give it a couple of weeks to see whether it wears off.

Thanks. I will do that! ;=)

Did you take Nortriptyline and or Amitriptyline in the past?

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by undopaminergic on November 10, 2020, at 0:11:03

In reply to Re: Currently on low dose Nortriptyline but not sure.. undopaminergic, posted by Skeletor on November 9, 2020, at 12:46:25

>
> Pramipexole sure is interesting, but difficult to come by... most doctors especially in Germany are afraid of full dopamine agonists ^^
>
> Imho Aripiprazole is interesting because it is pro-dopaminergic at low dosages (2 mg) and it exhibits 5HT2-antagonist-properties AND it isn't a strong antihistamine. But yeah, your mileage may vary.
>
> Low dosage of Olanzapine is also interesting, but strong antihistamine... ^^
>
> What is your current regimen?

Sulpiride 150 mg, clozapine 350 mg, cariprazine 1.5 mg, lamotrigine 200 mg, and most importantly, trimipramine 150 mg.

Clozapine is particularly useless in my experience. Sulpiride was even better than a stimulant when I first tried it, but this effect disappeared after some week or so. Cariprazine may be slightly activating, and I recommend it over aripiprazole. Lamotrigine seems to do nothing. Trimipramine is the best drug I've ever tried that is classified as an antidepressant.

-undopaminergic

 

Re: Currently on low dose Nortriptyline but not sure.. undopaminergic

Posted by Skeletor on November 10, 2020, at 19:24:02

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 10, 2020, at 0:11:03

> Trimipramine is the best drug I've ever tried that is classified as an antidepressant.
>
> -undopaminergic
>

That is interesting. Many people are quite satisfied with Trimipramine albeit it doesn't exhibit any Reuptake-Properties...

F*CK knows how these drugs work O_o

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 11, 2020, at 15:41:16

In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10

Today's poop was really hard to pass... O_o

 

Re: Currently on low dose Nortriptyline but not sure.. Skeletor

Posted by ed_uk2010 on November 13, 2020, at 18:36:37

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 11, 2020, at 15:41:16

> Today's poop was really hard to pass... O_o

Nortriptyline can be constipating yeah, take a stool softener.

And yes, I've taken amitriptyline.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 14, 2020, at 5:27:33

In reply to Re: Currently on low dose Nortriptyline but not sure.. Skeletor, posted by ed_uk2010 on November 13, 2020, at 18:36:37

>
> And yes, I've taken amitriptyline.
>
>

How was your experience?

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by ed_uk2010 on November 14, 2020, at 10:21:44

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 14, 2020, at 5:27:33

> >
> > And yes, I've taken amitriptyline.
> >
> >
>
> How was your experience?

It was too anticholinergic, although the drowsiness does reduce over time.

Typically, nortriptyline is more tolerable.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 15, 2020, at 8:36:14

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by ed_uk2010 on November 14, 2020, at 10:21:44

Not sure what to make of it.

One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it". It also f*cks with my teeth enamel...

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by undopaminergic on November 15, 2020, at 8:39:07

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 15, 2020, at 8:36:14

> Not sure what to make of it.
>
> One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it".
>

Interesting.

> It also f*cks with my teeth enamel...

Just keep the acids neutralised.

-undopaminergic

 

Re: Currently on low dose Nortriptyline but not sure.. undopaminergic

Posted by Skeletor on November 15, 2020, at 8:44:56

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 15, 2020, at 8:39:07

> > Not sure what to make of it.
> >
> > One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it".
> >
>
> Interesting.
>
> > It also f*cks with my teeth enamel...
>
> Just keep the acids neutralised.
>
> -undopaminergic
>

Interesting and somewhat paradoxal. I am continuing the test.

I bought a high concentrated fluoride toothpaste. Hope it will help to counter negative effects.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by undopaminergic on November 15, 2020, at 9:19:17

In reply to Re: Currently on low dose Nortriptyline but not sure.. undopaminergic, posted by Skeletor on November 15, 2020, at 8:44:56

> > > Not sure what to make of it.
> > >
> > > One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it".
> > >
> >
> > Interesting.
> >
> > > It also f*cks with my teeth enamel...
> >
> > Just keep the acids neutralised.
> >
> > -undopaminergic
> >
>
> Interesting and somewhat paradoxal. I am continuing the test.
>
> I bought a high concentrated fluoride toothpaste. Hope it will help to counter negative effects.
>

Some (eg. the holistic medicine proponents) say that fluoride can have adverse effects, notably on intelligence. I'd use xylitol and/or baking soda.

That said, I use flouride toothpaste myself, because of inertia (I'm too lazy and/or apathetic to arrange for better alternatives).

-undopaminergic

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Lamdage22 on November 16, 2020, at 6:16:21

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 15, 2020, at 9:19:17

There are people who have flouride allergy. Their teeth are rotten.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 16, 2020, at 9:35:31

In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10

Increased to 15mg of Nortriptyline.

So far: Bouts of Dysphoria, hot flashes and restlessness. Motivational spikes...

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 16, 2020, at 11:18:30

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 16, 2020, at 9:35:31

Some soft poop today... no diarrhea, but something in-between normal poop and diarrhea.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on November 25, 2020, at 13:20:53

In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10

Nortriptyline seems to make my "OCD" worse xD I've been obsessing about stupid stuff and was kinda anxious. NRIs do that? Generally speaking?

Although I am unsure if the worsening of OCDish features causes the anxiety or the other way around... sometimes it is difficult to distinguish

Yesterday...It was 23:30 PM... I still had 15 liters of fuel n my car-tank, but wanted to fill it up... first gas station was closed, the second one was too expensive, the third one was closing.... the forth too expensive, the fifth... closed and so on....I drove through half of Hamburg until I finally found a cheap open gas station....

totally obsessive and dumb... I surely made 35km and an hour of driving xD

That's what NTP does to me... but I am unsure which component causes it.

Presumably NRIs can cause agitation, anxiety, headache, restlessness and OCDish like side effects, but not sure ^^

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by Skeletor on December 9, 2020, at 9:30:07

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 25, 2020, at 13:20:53

Up to 25mg. My anxiety and agitation is definitely up. Feeling edgy and jumpy...

Weight has gone down. Shakiness and tremor has gone up.

Motivation has gone up. Wastefulness has gone up.

 

Re: Currently on low dose Nortriptyline but not sure..

Posted by undopaminergic on December 9, 2020, at 10:57:20

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on December 9, 2020, at 9:30:07

> Up to 25mg. My anxiety and agitation is definitely up. Feeling edgy and jumpy...
>
> Weight has gone down. Shakiness and tremor has gone up.
>
> Motivation has gone up. Wastefulness has gone up.

What about the teeth?

-undopaminergic

 

Re: Currently on low dose Nortriptyline but not sure.. undopaminergic

Posted by Skeletor on December 9, 2020, at 11:01:08

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on December 9, 2020, at 10:57:20

> > Up to 25mg. My anxiety and agitation is definitely up. Feeling edgy and jumpy...
> >
> > Weight has gone down. Shakiness and tremor has gone up.
> >
> > Motivation has gone up. Wastefulness has gone up.
>
> What about the teeth?
>
> -undopaminergic
>

Dry mouth got somewhat better. Actually a dry sore throat is the bigger problem.

I was at the dentist and he prescribed special drops to stimulate salvia production and release.


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