Psycho-Babble Medication Thread 1112378

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

Rexulti

Posted by phidippus on October 28, 2020, at 15:29:52

Has anyone here have any experience with Rexulti? Most specifically bipolar or unipolar depression?

 

Re: Rexulti

Posted by undopaminergic on October 29, 2020, at 1:29:07

In reply to Rexulti, posted by phidippus on October 28, 2020, at 15:29:52

> Has anyone here have any experience with Rexulti? Most specifically bipolar or unipolar depression?
>

From what I recall, Rexulti is brexpiprazole, which is similar to aripiprazole (Abilify) and cariprazine (Reagila). I have experience with both, in bipolar (looking more like unipolar) depression. I don't recall any benefit from aripiprazole, but it seemed to disturb accomodation (focussing with the eyes). Cariprazine at first seemed slightly activating at 1.5 mg; 3 mg was not better, but possibly worse.

-undopaminergic

 

Re: Rexulti phidippus

Posted by SLS on October 30, 2020, at 14:31:23

In reply to Rexulti, posted by phidippus on October 28, 2020, at 15:29:52

> Has anyone here have any experience with Rexulti? Most specifically bipolar or unipolar depression?

I found Rexulti do be less effective than Abilify as an antidepressant for me. I think D3/D2 ratio is higher for Abilify than Rexulti.

 

Re: Rexulti

Posted by creepy on October 31, 2020, at 0:03:40

In reply to Rexulti, posted by phidippus on October 28, 2020, at 15:29:52

personally I think the risk versus reward ratio for AP's in depression is unappealing. They marketed these for unipolar depression and now theyre marketing heavily for new meds for tardive dyskinesia. Doesnt seem very ethical.
I would stay clear of AP's unless I had psychosis or hypomania.

 

Re: Rexulti

Posted by undopaminergic on October 31, 2020, at 3:51:51

In reply to Re: Rexulti phidippus, posted by SLS on October 30, 2020, at 14:31:23

> > Has anyone here have any experience with Rexulti? Most specifically bipolar or unipolar depression?
>
> I found Rexulti do be less effective than Abilify as an antidepressant for me. I think D3/D2 ratio is higher for Abilify than Rexulti.
>

If you want high D3/D2, cariprazine is the best choice.

-undopaminergic

 

Re: Rexulti

Posted by Christ_empowered on November 2, 2020, at 11:22:49

In reply to Re: Rexulti, posted by undopaminergic on October 31, 2020, at 3:51:51

unless the issue at hand is psychotic depression or depression with -significant- agitation, i don't see the justification for a neuroleptic. from what i've skimmed over on the data for aripiprazole, the aggregate shows a minor drop in misery scores, no indication of improvement in quality of life or anything...anything that would justify the risks and expen$e.

if the main issue is Bipolar I, then maybe a neuroleptic is acceptable? even then, the traditional treatment protocols called for minimizing exposure to neuroleptics in Bipolar I when possible, because Bipolar I people are apparently more prone to EPS, more likely to develop TD, and the TD in this group of people is more likely to be on the severe end vs those with a diagnosis of Schizophrenia. but that could just be more psych 'wisdom' that is/was based on assumptions, dogma, and low quality data. who knows? not me...

have you (or whomever the question is about...) given aripiprazole a trial? I take it, daily. ugh. its...OK. for my "condition," a neuroleptic is usually standard, so its more a question of dosage, which tranquilizer, and what if any additional psych drugs are needed, etc.

from what -very- little 'expert' opinion i've read on the issue, it would appear that aripiprazole is a better 1st option, -if- a neuroleptic is needed. the data isn't there to justify the additional costs and still largely unknown risks with the newer me-too drugs.

and...im finished. lol. hope this helps. :-)

 

Re: Rexulti SLS

Posted by Skeletor on December 18, 2020, at 16:50:18

In reply to Re: Rexulti phidippus, posted by SLS on October 30, 2020, at 14:31:23

Yeah... well, Aripiprazole seems to be the overall better antidepressant when comparing their pharmacologys ....

> > Has anyone here have any experience with Rexulti? Most specifically bipolar or unipolar depression?
>
> I found Rexulti do be less effective than Abilify as an antidepressant for me. I think D3/D2 ratio is higher for Abilify than Rexulti.

 

Re: Rexulti

Posted by SLS on December 28, 2020, at 18:52:11

In reply to Re: Rexulti, posted by Christ_empowered on November 2, 2020, at 11:22:49

Do you think primavanserin (Nuplazid) would act as an antipsychotic for disorders other than Parkinson's Disease?


- Scott

 

Re: Rexulti SLS

Posted by undopaminergic on December 31, 2020, at 8:45:59

In reply to Re: Rexulti, posted by SLS on December 28, 2020, at 18:52:11

> Do you think primavanserin (Nuplazid) would act as an antipsychotic for disorders other than Parkinson's Disease?
>

I think that if it works for psychosis in Parkinsons' disease, it works for psychosis in general. I doubt it's very effective in comparison with other anti-psychotics, however -- I hope I'm wrong, because an antipsychotic that doesn't block dopamine receptors is badly needed.

-undopaminergic


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