Psycho-Babble Medication Thread 1110060

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nature article rethinking comorbidity dx's

Posted by beckett2 on May 11, 2020, at 21:57:24

https://www.nature.com/articles/d41586-020-00922-8

 

Re: nature article rethinking comorbidity dx's

Posted by undopaminergic on May 12, 2020, at 8:52:59

In reply to nature article rethinking comorbidity dx's, posted by beckett2 on May 11, 2020, at 21:57:24

> https://www.nature.com/articles/d41586-020-00922-8

Very interesting!

-undopaminergic

 

Re: nature article rethinking comorbidity dx's undopaminergic

Posted by linkadge on May 12, 2020, at 11:32:41

In reply to Re: nature article rethinking comorbidity dx's, posted by undopaminergic on May 12, 2020, at 8:52:59

Yeah,

I'm currently being treated with 2 antidepressants, a mood stabilizer and a stimulant.....

Not really clear what is going on to be honest.

I've tried just lithium and Ritalin, but it leaves me feeling pretty dark.

The fact is that many of these disorders likely have little to do with neurotransmitter imbalances. There are likely much deeper problems dealing with cellular function, plasticity etc.


Linkadge

 

Re: nature article rethinking comorbidity dx's

Posted by undopaminergic on May 12, 2020, at 11:41:34

In reply to Re: nature article rethinking comorbidity dx's undopaminergic, posted by linkadge on May 12, 2020, at 11:32:41

>
> The fact is that many of these disorders likely have little to do with neurotransmitter imbalances. There are likely much deeper problems dealing with cellular function, plasticity etc.
>

Yes, and if there *are* neurotransmitter imbalances, they are likely symptoms and not the cause.

-undopaminergic

 

Re: nature article rethinking comorbidity dx's undopaminergic

Posted by linkadge on May 12, 2020, at 15:14:47

In reply to Re: nature article rethinking comorbidity dx's, posted by undopaminergic on May 12, 2020, at 11:41:34

>Yes, and if there *are* neurotransmitter >imbalances, they are likely symptoms and not the >cause.

Exactly. For example, decades of research looking into dysfunctional d2, COMT, DAT, MAO-B etc have yielded little to nothing in schizophrenia research. Some of the genes that have been uncovered are in things like the immune system, cellular adhesion, gene transcription, intracellular stuff (stuff that is way beyond my comprehension).


For bipolar, interestingly, there is some linkage with genes like ANK3 and CACNA1 (which regulate sodium and calcium channels) although potassium channels have been implicated in some bipolar studies (something not affected by conventional mood stabilizers).

Linkadge

 

Re: nature article rethinking comorbidity dx's

Posted by Lamdage22 on May 12, 2020, at 21:39:40

In reply to Re: nature article rethinking comorbidity dx's undopaminergic, posted by linkadge on May 12, 2020, at 15:14:47

That is really interesting. However I think sometimes it is just psychological distress during the time when the brain was forming. Could that lead to biological dysfunction? I think so.

 

Re: nature article : everyone must read this!

Posted by PCB on June 17, 2020, at 1:57:21

In reply to Re: nature article rethinking comorbidity dx's undopaminergic, posted by linkadge on May 12, 2020, at 15:14:47

Wow! Everyone should read this. My old pdoc use to say you need like 500 to 1000 small genetic mutations to demonstrate symptoms of an illness like depresion, bipolar, schizo. And he did talk about dimensional approach to categorizing patients.

Maybe I shouldnt have switched from him? I have alway said I am 50% anxiety, 25% depression and 25% bipolar.

 

Re: nature article : everyone must read this!

Posted by Lamdage22 on June 18, 2020, at 2:37:37

In reply to Re: nature article : everyone must read this!, posted by PCB on June 17, 2020, at 1:57:21

I also have features of both bipolar and unipolar. Without Antidepressants more unipolar.


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