Psycho-Babble Medication Thread 1110321

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Super probiotics of the near future for depression

Posted by Hugh on May 25, 2020, at 13:11:57

The allure is simple: Drug development for neuropsychiatric disorders has lagged for decades, and many existing drugs don't work for all patients and cause unwanted side effects. A growing number of researchers see a promising alternative in microbe-based treatments, or "psychobiotics," a term coined by neuropharmacologist John Cryan and psychiatrist Ted Dinan, both at University College Cork. "This is a really young and really exciting field with a huge amount of potential," says Natalia Palacios, an epidemiologist at the University of Massachusetts, Lowell, who is looking into connections between gut microbes and Parkinson's disease.

Researchers have also noticed an increase in depression in people taking antibiotics -- but not antiviral or antifungal medications that leave gut bacteria unharmed. Last year, Jeroen Raes, a microbiologist at the Catholic University of Leuven, and colleagues analyzed the health records of two groups -- one Belgian, one Dutch -- of more than 1000 people participating in surveys of their types of gut bacteria. People with depression had deficits of the same two bacterial species, the authors reported in April 2019 in Nature Microbiology.

Complete article:

https://www.sciencemag.org/news/2020/05/meet-psychobiome-gut-bacteria-may-alter-how-you-think-feel-and-act

 

Re: Super probiotics of the near future for depression » Hugh

Posted by linkadge on May 26, 2020, at 5:11:27

In reply to Super probiotics of the near future for depression, posted by Hugh on May 25, 2020, at 13:11:57

Yeah, at first I thought this theory was a bit quackish (had a friend 10 years a go that was trying to explain to me the brain gut connection). However, the more I read the more sense it makes.

For instance, I was reading on the gut's response to the supplement (amino acid) GABA. The supplement was said 'not to work' because it didn't cross the blood brain barrier.

However, I read a recent article suggesting that gut bacteria easily could convert GABA into Ketones (which have psychoactive effects) which readily cross the BBB. Perhaps this is how GABA works. It's not a placebo for me (that I know of).

Linkadge

 

Re: Super probiotics of the near future for depression

Posted by Lamdage22 on May 26, 2020, at 10:10:04

In reply to Re: Super probiotics of the near future for depression » Hugh, posted by linkadge on May 26, 2020, at 5:11:27

What are the effects of Ketones?

 

Re: Super probiotics of the near future for depression » linkadge

Posted by Hugh on May 28, 2020, at 10:19:36

In reply to Re: Super probiotics of the near future for depression » Hugh, posted by linkadge on May 26, 2020, at 5:11:27

It makes sense that GABA supplements would affect the brain via the gut.

 

Re: Super probiotics of the near future for depression

Posted by Hugh on May 28, 2020, at 10:28:07

In reply to Super probiotics of the near future for depression, posted by Hugh on May 25, 2020, at 13:11:57

Intriguing new research from the University of Colorado Boulder suggests that one particular bacteria could have beneficial anti-inflammatory effects on the brain. Early studies in rodent models have found that through injections of the bacteria the animals can be essentially "immunized" against displaying anxious responses to stressful situations.

"We found that in rodents this particular bacterium, Mycobacterium vaccae, actually shifts the environment in the brain toward an anti-inflammatory state," says Matthew Frank, lead author of the new study.

Mycobacterium vaccae was first discovered in the 1990s in soil near the shores of Lake Kyoga in Uganda. It turned out the bacterium was from the same genus as that which causes tuberculosis. Interestingly, scientists noticed that people living in the vicinity of the lake in Uganda tended to respond to tuberculosis vaccines better than others. Since then, research into this mysterious bacterium has been booming.

Initially, researchers were studying Mycobacterium vaccae for its immune-modulating properties. In 2004, a trial using the bacterium as an adjunct to chemotherapy in lung cancer patients failed to improve survival rates but it did deliver a curious side effect. Patients receiving the bacterium displayed a significantly improved mood, leading researchers to begin exploring its cognitive effects.

Unlike other probiotic delivery mechanisms that are more geared at being consumed orally, to enter the gut and alter one's microbiome, this technique operates more like a traditional vaccine - an injection of an inert compound that stimulates the body to produce its own beneficial response. In other words, a literal immunization against stress, depression and anxiety.

Complete article:

https://newatlas.com/probiotic-bacteria-immunization-anxiety-depression/54950/

 

Re: Super probiotics of the near future for depression

Posted by beckett2 on May 30, 2020, at 16:26:55

In reply to Re: Super probiotics of the near future for depression, posted by Hugh on May 28, 2020, at 10:28:07

> Intriguing new research from the University of Colorado Boulder suggests that one particular bacteria could have beneficial anti-inflammatory effects on the brain. Early studies in rodent models have found that through injections of the bacteria the animals can be essentially "immunized" against displaying anxious responses to stressful situations.
>
> "We found that in rodents this particular bacterium, Mycobacterium vaccae, actually shifts the environment in the brain toward an anti-inflammatory state," says Matthew Frank, lead author of the new study.
>
> Mycobacterium vaccae was first discovered in the 1990s in soil near the shores of Lake Kyoga in Uganda. It turned out the bacterium was from the same genus as that which causes tuberculosis. Interestingly, scientists noticed that people living in the vicinity of the lake in Uganda tended to respond to tuberculosis vaccines better than others. Since then, research into this mysterious bacterium has been booming.
>
> Initially, researchers were studying Mycobacterium vaccae for its immune-modulating properties. In 2004, a trial using the bacterium as an adjunct to chemotherapy in lung cancer patients failed to improve survival rates but it did deliver a curious side effect. Patients receiving the bacterium displayed a significantly improved mood, leading researchers to begin exploring its cognitive effects.
>
> Unlike other probiotic delivery mechanisms that are more geared at being consumed orally, to enter the gut and alter one's microbiome, this technique operates more like a traditional vaccine - an injection of an inert compound that stimulates the body to produce its own beneficial response. In other words, a literal immunization against stress, depression and anxiety.
>
> Complete article:
>
> https://newatlas.com/probiotic-bacteria-immunization-anxiety-depression/54950/

This is mind-blowing. A vaccine! By the end of my lifetime, we may look back on many mental health conditions the way we used to look at tuberculosis as 'consumption', romanticized as an illness caused by sensitivity (La Bohéme). Born too soon.

 

Re: Super probiotics of the near future for depression

Posted by beckett2 on May 30, 2020, at 16:36:37

In reply to Super probiotics of the near future for depression, posted by Hugh on May 25, 2020, at 13:11:57

> The allure is simple: Drug development for neuropsychiatric disorders has lagged for decades, and many existing drugs don't work for all patients and cause unwanted side effects. A growing number of researchers see a promising alternative in microbe-based treatments, or "psychobiotics," a term coined by neuropharmacologist John Cryan and psychiatrist Ted Dinan, both at University College Cork. "This is a really young and really exciting field with a huge amount of potential," says Natalia Palacios, an epidemiologist at the University of Massachusetts, Lowell, who is looking into connections between gut microbes and Parkinson's disease.
>
> Researchers have also noticed an increase in depression in people taking antibiotics -- but not antiviral or antifungal medications that leave gut bacteria unharmed. Last year, Jeroen Raes, a microbiologist at the Catholic University of Leuven, and colleagues analyzed the health records of two groups -- one Belgian, one Dutch -- of more than 1000 people participating in surveys of their types of gut bacteria. People with depression had deficits of the same two bacterial species, the authors reported in April 2019 in Nature Microbiology.
>
> Complete article:
>
> https://www.sciencemag.org/news/2020/05/meet-psychobiome-gut-bacteria-may-alter-how-you-think-feel-and-act

I wonder how commonly or easily available fecal transplants are to be had.

 

Re: Super probiotics of the near future for depression

Posted by Lamdage22 on May 31, 2020, at 17:28:50

In reply to Re: Super probiotics of the near future for depression, posted by beckett2 on May 30, 2020, at 16:36:37

I wonder how safe they are. I'd be careful.

> I wonder how commonly or easily available fecal transplants are to be had.

 

Re: Super probiotics of the near future for depression » beckett2

Posted by Hugh on June 1, 2020, at 14:36:02

In reply to Re: Super probiotics of the near future for depression, posted by beckett2 on May 30, 2020, at 16:36:37

> I wonder how commonly or easily available fecal transplants are to be had.

Over 1000 fecal transplant doctors can be found at this site. This is for the treatment of C. diff, but some of these doctors might be willing to treat depression. I know that some of these doctors use fecal transplants to treat obesity.

https://www.openbiome.org/find-a-doctor

 

Re: Super probiotics of the near future for depression

Posted by Hugh on June 3, 2020, at 13:30:20

In reply to Super probiotics of the near future for depression, posted by Hugh on May 25, 2020, at 13:11:57

It's been widely reported how the mix of our gut bacteria can end up having a direct impact on our health. Now, new research points to a similar link between our wellbeing and the microbiome in the nose.

That's right - your nose is home to an entire host of microorganisms, just like the rest of your body. The different types of 'good' or 'bad' bacteria specific to the nasal cavities might end up protecting you from certain health issues, or putting you more at risk of others.

Lebeer and her team analysed nose bacteria from 100 healthy volunteers and 225 people with chronic rhinosinusitis, characterising 30 different families of bacteria in all. One family in particular stood out: lactobacilli.

These bacteria were more abundant in the healthy group of study participants up to 10 times more abundant in some cases. One particular strain of Lacticaseibacillus identified appeared to have adapted for nasal life, having evolved unique genes to manage the high oxygen levels in the cavity, and using thin tubes called fimbriae to help cling on.

In the end, the team created an experiment where one lactobacillus strain was sprayed into the noses of 20 healthy volunteers, twice daily for two weeks. While the nasal cavity typically filters out foreign bodies, here the bacteria were able to colonise.

That said, the study shows enough evidence that the microbiomes in our noses could affect our health, just like the microbiomes in our stomachs and elsewhere in the body.

Further down the line, we might be able to come up with safe, effective treatments that can grow certain nose bacteria for improved wellbeing.

Complete article:

https://www.sciencealert.com/your-nose-bacteria-might-play-a-role-in-good-health-just-like-the-gut-microbiome

 

Re: Super probiotics of the near future for depression

Posted by alchemy on June 5, 2020, at 16:36:31

In reply to Re: Super probiotics of the near future for depression, posted by Hugh on June 3, 2020, at 13:30:20

The relationship with the microbiome and mood is huge. My depression is worse with both antibiotics AND probiotics (even one specifically for mood).

 

Re: Super probiotics of the near future for depression

Posted by Hugh on June 30, 2020, at 11:39:45

In reply to Super probiotics of the near future for depression, posted by Hugh on May 25, 2020, at 13:11:57

Recent studies have found that a prebiotic mixture that you can make yourself can have a "remarkable" effect on your health.

https://www.npr.org/sections/goatsandsoda/2019/07/11/740820882/a-mix-of-these-foods-could-restore-healthy-microbes-in-malnourished-kids

This prebiotic mixture is composed of chickpea flour, peanut flour, soy flour, green banana flour, sugar, and soybean oil. All of these ingredients can be ordered from Amazon.

Here's the study, which has information on the doses that were used:

https://science.sciencemag.org/content/365/6449/eaau4735


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