Psycho-Babble Medication Thread 1110212

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Mechanism of Sleep Deprivation in Depression

Posted by linkadge on May 17, 2020, at 18:12:41

They suggest that it is related to increased adenosine:

https://www.scientificamerican.com/article/why-sleep-deprivation-eases-depression/

 

Re: Mechanism of Sleep Deprivation in Depression

Posted by undopaminergic on May 18, 2020, at 3:02:05

In reply to Mechanism of Sleep Deprivation in Depression, posted by linkadge on May 17, 2020, at 18:12:41

> They suggest that it is related to increased adenosine:
>
> https://www.scientificamerican.com/article/why-sleep-deprivation-eases-depression/
>

Caffeine blocks adenosine receptors. Does that mean it worsens depression?

-undopaminergic

 

Re: Mechanism of Sleep Deprivation in Depression undopaminergic

Posted by linkadge on May 18, 2020, at 8:15:26

In reply to Re: Mechanism of Sleep Deprivation in Depression, posted by undopaminergic on May 18, 2020, at 3:02:05

Caffeine could possibly produce depression in some individuals. I do get a perk from sleep deprivation and it seems that drinking coffee the next morning seems to bring my mood down a bit. But at other times, it can improve my mood.

That being said, A1 antagonists (including caffeine) do produce antidepressant effects in some animal models. Also, A2 antagonists (including caffeine) produce neuroprotective effects and may reduce the risk of parkinsons.

Linakdge

 

Re: Mechanism of Sleep Deprivation in Depression linkadge

Posted by undopaminergic on May 18, 2020, at 9:03:55

In reply to Re: Mechanism of Sleep Deprivation in Depression undopaminergic, posted by linkadge on May 18, 2020, at 8:15:26

> Caffeine could possibly produce depression in some individuals. I do get a perk from sleep deprivation and it seems that drinking coffee the next morning seems to bring my mood down a bit. But at other times, it can improve my mood.
>
> That being said, A1 antagonists (including caffeine) do produce antidepressant effects in some animal models. Also, A2 antagonists (including caffeine) produce neuroprotective effects and may reduce the risk of parkinsons.
>
> Linakdge

I find that (1) I get little effect either way from caffeine alone, but (2) taken with a cocaine-like stimulant (in my case desoxypipradrol or ethylphenidate) it provides an excellent nootropic boost. I have tried up to 3000 mg of caffeine alone, without any notable benefits, but the worst night of my life due to stomach pains. Whence the complete contrast between (1) and (2)?

-undopaminergic

 

Re: Mechanism of Sleep Deprivation in Depression linkadge

Posted by Jadde on May 18, 2020, at 10:34:14

In reply to Mechanism of Sleep Deprivation in Depression, posted by linkadge on May 17, 2020, at 18:12:41

> They suggest that it is related to increased adenosine:
>
> https://www.scientificamerican.com/article/why-sleep-deprivation-eases-depression/

I was euphoric for a full day following a night of no sleep. Its tempting.

Jade

 

Re: Mechanism of Sleep Deprivation in Depression Jadde

Posted by linkadge on May 18, 2020, at 10:42:23

In reply to Re: Mechanism of Sleep Deprivation in Depression linkadge, posted by Jadde on May 18, 2020, at 10:34:14

>I was euphoric for a full day following a night of >no sleep. Its tempting.

After reading on the mechanism (adenosine increase) I looked for other agents which can increase adenosine. All I could find were magnesium, pot and valerian root. Valerian is an A1 adenosine agonist and magnesium (although it doesn't raise adenosine on its own) is required for the synaptic actions of adenosine (i.e magnifying the effects). Pot increases adenosine via activation of the cb1 receptors. I do get a mood improvement with marijuana and magnesium seems to potentiate the effect. I wonder if marijuanna could potentiate the effects of sleep deprivation on depression.

Linkadge


 

Re: Mechanism of Sleep Deprivation in Depression Jadde

Posted by undopaminergic on May 18, 2020, at 11:18:40

In reply to Re: Mechanism of Sleep Deprivation in Depression linkadge, posted by Jadde on May 18, 2020, at 10:34:14

> > They suggest that it is related to increased adenosine:
> >
> > https://www.scientificamerican.com/article/why-sleep-deprivation-eases-depression/
>
> I was euphoric for a full day following a night of no sleep. Its tempting.
>
> Jade
>

I would use it if I could. I'm just too apathetic, and a bit tired, in the evening so I can't stay awake.

-undopaminergic

 

Re: Mechanism of Sleep Deprivation in Depression

Posted by alchemy on June 5, 2020, at 16:37:58

In reply to Mechanism of Sleep Deprivation in Depression, posted by linkadge on May 17, 2020, at 18:12:41

Interesting.


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