Psycho-Babble Medication Thread 1109395

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Thyroid NET and DAT

Posted by linkadge on April 4, 2020, at 8:18:54

Thyroid acts as a specific norepinephrine and dopamine reuptake inhibitor:

https://www.ncbi.nlm.nih.gov/pubmed/17530732

Linkadge

 

Re: Thyroid NET and DAT

Posted by rjlockhart37 on April 4, 2020, at 20:57:02

In reply to Thyroid NET and DAT, posted by linkadge on April 4, 2020, at 8:18:54

yeah hypothyroidism tiredness, slow motivation So that makes sense, low dopamine and norepinephrine. Hyperthyroidism is miserable, it worse than hypothyroidism

 

Re: Thyroid NET and DAT

Posted by undopaminergic on April 5, 2020, at 11:53:53

In reply to Thyroid NET and DAT, posted by linkadge on April 4, 2020, at 8:18:54

> Thyroid acts as a specific norepinephrine and dopamine reuptake inhibitor:
>
> https://www.ncbi.nlm.nih.gov/pubmed/17530732
>
> Linkadge

My understanding of the abstract is that there are metabolites of thyroid hormones, called thyronamines, that act as inhibitors of NAT, and DAT, and they also inhibit vesicular monoamine uptake, apparently via agonism at the TAARs. Sounds very much like amphetamines (and trace amines like PEA), but the article does not mention any monoamine releasing activity.

-undopaminergic

 

Re: Thyroid NET and DAT

Posted by alchemy on May 16, 2020, at 21:54:55

In reply to Re: Thyroid NET and DAT, posted by undopaminergic on April 5, 2020, at 11:53:53

Some research has also shown that T3 is found in the junctions of synapses, and regulates the amounts and activity of serotonin, norepinephrine, and γ-aminobutyric acid (GABA) in the brain.


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