Psycho-Babble Medication Thread 1109643

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Parnate once a day: has anyone tried it?

Posted by gjg91 on April 18, 2020, at 11:16:26

Hello everyone! I wondered if someone had tried taking Parnate once a day (I take 60mg/day). Here's why:

Every dose of Parnate produces the same pattern: [30 min of "energy" > huge sleepiness]

I would like to take it once in the morning to get rid of this "up and down" pattern soon during the day.

(This way, I would benefit from the real antidepressant effect from the MAO inhibition without having to deal constantly with the stimulant effect, which is not helpful for me.)

I've done that with Nardil for many years until the backorder 😢 and it brought me amazing stability.

However, the amphetamine-like effect of Parnate is very intense. Do you think that taking 60mg at once would be... too much?

Thank you very much in advance for your help!

 

Re: Parnate once a day: has anyone tried it?

Posted by rjlockhart37 on April 18, 2020, at 12:58:44

In reply to Parnate once a day: has anyone tried it?, posted by gjg91 on April 18, 2020, at 11:16:26

i've never taken parnate, but over the years of being on this board....parnate start off stimulating just like you said, psychostimulant effect like amphetmamine, but later in the day, fatigue happen. The bet thing is to take twice a day. At least that's what i've rread, after the first dose your tired and sleepy and want to rest.

My best guess, is to tak twice a day, there are many people here over the years .... there not here anymore, but their posts are in arvives, about parnate, stimulation = then tired and fatgue.

Twice a day i think is best, maybe even 3 times a day, think of it like this....wellbutrin XL,, bupropion only lasts about 4-5 hours, then you have to redose or you get tired. Wellbutrin XL is a form were it relases it 3 times a day, so you take the 300mg tablet, at 9am it releases 100mg of bupropion, then around mid day 12pm-1pm release again, then last release around 5-6pm last release.

But i have no expereince with parante.....i wish there were people back here like back in the day in the 2000s who were experts at explaning it

hope this helps but i really don't know what to say about parante since ive never taken it

 

Re: Parnate once a day: has anyone tried it?

Posted by gjg91 on April 18, 2020, at 16:55:05

In reply to Re: Parnate once a day: has anyone tried it?, posted by rjlockhart37 on April 18, 2020, at 12:58:44

Thank you, rjlockhart37, for taking the time to answer my question!

I had taken Parnate some years ago: I tried Nardil, Parnate, Nardil again (because it worked much better for me)... until the "worldwide shortage of the active ingredient" of Nardil forced me to take Parnate again, hahaha.

The first time, I divided doses like you said, even 4 times a day. The stimulant effect was difficult to sustain, and the result, strangely, was an intense sedation. Almost like the effect of a strong antipsychotic.

That's why I thought about "getting rid" from this acute effect in the morning, while keeping the real antidepressant effect of the med. In theory, the MAO inhibition should provide a sustained therapeutic effect, regardless of the molecule half-life.
It was clearly the case with Nardil, which worked like a charm all day long despite its short half-live... but it's true that both meds are very different!

 

Re: Parnate once a day: has anyone tried it?

Posted by Lamdage22 on April 18, 2020, at 23:19:49

In reply to Re: Parnate once a day: has anyone tried it?, posted by gjg91 on April 18, 2020, at 16:55:05

I hear Marplan has no stimulant effects, just pure MAO Inhibition

 

Re: Parnate once a day: has anyone tried it?

Posted by undopaminergic on April 19, 2020, at 4:23:57

In reply to Parnate once a day: has anyone tried it?, posted by gjg91 on April 18, 2020, at 11:16:26

> Hello everyone! I wondered if someone had tried taking Parnate once a day (I take 60mg/day). Here's why:
>
> Every dose of Parnate produces the same pattern: [30 min of "energy" > huge sleepiness]
>
> I would like to take it once in the morning to get rid of this "up and down" pattern soon during the day.
>
> (This way, I would benefit from the real antidepressant effect from the MAO inhibition without having to deal constantly with the stimulant effect, which is not helpful for me.)
>
> I've done that with Nardil for many years until the backorder 😢 and it brought me amazing stability.
>
> However, the amphetamine-like effect of Parnate is very intense. Do you think that taking 60mg at once would be... too much?
>
> Thank you very much in advance for your help!

If you don't want the stimulant effect at all, how about switching to Marplan?

If you want a longer stimulant effect than Parnate provides, you might try augmenting with amphetamine.

-undopaminergic

 

Re: Parnate once a day: has anyone tried it?

Posted by Lamdage22 on April 19, 2020, at 4:33:37

In reply to Re: Parnate once a day: has anyone tried it?, posted by Lamdage22 on April 18, 2020, at 23:19:49

Nardil would be another option. Especially if you have anxiety. I wouldn't take amphetamine. Look at people who have taken it for decades. It's not pretty.

 

Re: Parnate once a day: has anyone tried it? Lamdage22

Posted by linkadge on April 19, 2020, at 8:19:35

In reply to Re: Parnate once a day: has anyone tried it?, posted by Lamdage22 on April 19, 2020, at 4:33:37

I'm sure it would work. I never really understood the logic of taking it 3x a day. It is an 'irreversible' inhibitor of MAO, meaning it takes your system weeks to re-generate more MAO.

Give it a try.

Linkadge

 

Re: Parnate once a day: has anyone tried it?

Posted by undopaminergic on April 19, 2020, at 9:30:24

In reply to Re: Parnate once a day: has anyone tried it? Lamdage22, posted by linkadge on April 19, 2020, at 8:19:35

> I'm sure it would work. I never really understood the logic of taking it 3x a day. It is an 'irreversible' inhibitor of MAO, meaning it takes your system weeks to re-generate more MAO.
>

Yes, but taking it in three doses can help smoothe out the stimulant effect. I don't recall (if there is anything to recall; maybe it isn't known) the relative potency of tranylcypromine for releasing the three monoamines respectively, so I don't know if the worry is serotonin syndrome or hypertensive crisis (in case of excessive noradrenaline release).

-undopaminergic

 

Re: Parnate once a day: has anyone tried it? undopaminergic

Posted by linkadge on April 19, 2020, at 18:21:46

In reply to Re: Parnate once a day: has anyone tried it?, posted by undopaminergic on April 19, 2020, at 9:30:24

True. But I've heard that Nardil too is typically dosed more than once a day. I didn't understand that as the biological effect would go much longer than the half life.

I found the stimulant effect of parnate fairly mild. It was a kick-*ss antidepressant, but unfortunately, I had bad insomnia and a spontaneous hypertensive crisis.

Linkadge

 

Re: Parnate once a day: has anyone tried it?

Posted by gjg91 on April 19, 2020, at 19:46:40

In reply to Re: Parnate once a day: has anyone tried it? undopaminergic, posted by linkadge on April 19, 2020, at 18:21:46

Thank you all for your answers!

Most of the time, I prefer to take informations from official websites, but in the case of MAOIs, others' advices and experiences can be more than helpful.

Nardil was really the medication that worked for me; I would never have stopped taking it if I hadn't be forced to... For some months, there is a shortage. Some people (like myself) found pharmacies that able to order it.
But it seems the active ingredient is now missing worldwide, and the company said it would not be available before May 2020 or later.

Marplan is simply not available in Canada (!), so there's only Parnate left. Still much better than nothing (or SSRIs), but very different.

I'll try to find the best way to minimize its side effects and find a good quality of life, but the best solution will probably be to switch back to Nardil when (if) it's back. (The washout period is hell, but that's another story!)

 

Re: Parnate once a day: has anyone tried it?

Posted by undopaminergic on April 20, 2020, at 3:08:27

In reply to Re: Parnate once a day: has anyone tried it?, posted by gjg91 on April 19, 2020, at 19:46:40

>
> I'll try to find the best way to minimize its side effects and find a good quality of life, but the best solution will probably be to switch back to Nardil when (if) it's back. (The washout period is hell, but that's another story!)
>

A washout period would be necessary if eg. you were switching from a MAOIs to an SSRI, but there is no need for it when switching to another MAOI. A cross-taper would do.

-undopaminergic

 

Re: Parnate once a day: has anyone tried it?

Posted by gjg91 on April 20, 2020, at 15:38:20

In reply to Re: Parnate once a day: has anyone tried it?, posted by undopaminergic on April 20, 2020, at 3:08:27

I'm very, very, very, very happy to read that!

This 14 days washout period between MAOIs that is officially recommended doesn't seem logical to me either (although I try to remind myself pharmacology is always more complicated that it seems, especially because I'm not a scientist!)
It seems definitely weird to make the body restore completely its MAO... to start re-inhibiting it with a new MAOI later.

I've actually shortened the washout to 10 days when I made the switch from Nardil to Parnate, principally because it was unbearable at the end.

So it's really encouraging to think I won't have to live hell again for 14 days if I have to go back to Nardil ;-)

Thank you!

 

Re: Parnate once a day: has anyone tried it?

Posted by undopaminergic on April 21, 2020, at 3:04:02

In reply to Re: Parnate once a day: has anyone tried it?, posted by gjg91 on April 20, 2020, at 15:38:20

> ... pharmacology is always more complicated that it seems, ...
>

I think the main difficulty, perhaps especially in psychopharmacology, is that the same drugs work so differently for different people. But sure, keeping track of the liver enzymes and interactions can be difficult too -- sometimes you may need to take blood samples and determine the concentrations of drugs.

> It seems definitely weird to make the body restore completely its MAO... to start re-inhibiting it with a new MAOI later.
>

Haha, exactly, that is an amusing way to put it.

-undopaminergic

 

Re: Parnate once a day: has anyone tried it?

Posted by gjg91 on April 21, 2020, at 9:27:57

In reply to Re: Parnate once a day: has anyone tried it?, posted by undopaminergic on April 21, 2020, at 3:04:02

Clearly more amusing than living this 14 days washout without knowing if it is necessary! ;-)


> Haha, exactly, that is an amusing way to put it.
>
> -undopaminergic
>


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