Psycho-Babble Medication Thread 1109222

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Tardive dyskinesia

Posted by undopaminergic on March 25, 2020, at 13:50:54

I read the Wikipedia article on tardive dyskinesia (TD):
https://en.wikipedia.org/wiki/Tardive_dyskinesia

It reports an alarming prevalence of TD.

"Rates in those on atypical antipsychotics are about 20%, while those on typical antipsychotics have rates of about 30%."

"A study being conducted at the Yale University School of Medicine has estimated that "32% of people develop persistent tics after 5 years on major tranquilizers, ..."

But this does not appear to be true. My psychologist, who has worked at "my" hospital for a long time, says she used to see people around here who had symptoms of TD, but she doesn't see this any more. My own personal observations are in agreement with this, because I have seen 0 cases myself, either here or in another hospital I was at. Almost all patients here are receiving treatment with anti-psychotics, yet there is very little, if any, TD.

Has anyone here experienced TD?

-undopaminergic

 

Re: Tardive dyskinesia

Posted by linkadge on March 25, 2020, at 16:27:38

In reply to Tardive dyskinesia, posted by undopaminergic on March 25, 2020, at 13:50:54

I have not. If I recall, you are on clozapine which has a relatively low d2 receptor occupancy. It also has 5-ht1a agonism which is hypothesized to inhibit the development of TD.

Linkadge

 

Re: Tardive dyskinesia

Posted by undopaminergic on March 26, 2020, at 5:03:42

In reply to Re: Tardive dyskinesia, posted by linkadge on March 25, 2020, at 16:27:38

> I have not. If I recall, you are on clozapine which has a relatively low d2 receptor occupancy. It also has 5-ht1a agonism which is hypothesized to inhibit the development of TD.
>
> Linkadge

I'm actually on 3 anti-psychotics, including clozapine, sulpiride, and cariprazine. Additionally, trimipramine has substantial anti-psychotic activity.

It's crazy, yes, given how diminutive my psychotic symptoms are.

The 5-HT1A agonism was news to me. I also read that it increases dopamine release in the prefrontal cortex in part due to this action.

-undopaminergic

 

Re: Tardive dyskinesia

Posted by Lamdage22 on March 26, 2020, at 5:35:20

In reply to Re: Tardive dyskinesia, posted by undopaminergic on March 26, 2020, at 5:03:42

Hey, why so many antipsychotics? Are you even schizophrenic or schizo-affective?

 

Re: Tardive dyskinesia

Posted by Lamdage22 on March 26, 2020, at 6:00:52

In reply to Re: Tardive dyskinesia, posted by undopaminergic on March 26, 2020, at 5:03:42

What symptoms do you have / did you have before you took the APs? That doesn't add up. 3 Antipsychotics and only mild symptoms.

 

Re: Tardive dyskinesia

Posted by linkadge on March 26, 2020, at 6:25:19

In reply to Re: Tardive dyskinesia, posted by undopaminergic on March 26, 2020, at 5:03:42

Yeah, 5-ht1a agonism is generally neuroprotective and neurotrophic. Adding 5-ht1a agonists to lower doses of typical antipsychotics can enhance their antipsychotic properties (including some of the negative symptoms) and reduce side effects like TD.

Linkadge

 

Re: Tardive dyskinesia

Posted by Lamdage22 on March 26, 2020, at 9:29:48

In reply to Re: Tardive dyskinesia, posted by linkadge on March 26, 2020, at 6:25:19

Hi linkadge,

how would I achieve this without too many side effects?

 

Re: Tardive dyskinesia

Posted by undopaminergic on March 26, 2020, at 12:26:30

In reply to Re: Tardive dyskinesia, posted by Lamdage22 on March 26, 2020, at 6:00:52

> Hey, why so many antipsychotics? Are you even schizophrenic or schizo-affective?

> What symptoms do you have / did you have before you took the APs? That doesn't add up. 3 Antipsychotics and only mild symptoms.
>

I just had some harmless delusions, but I do have a schizophrenia diagnosis. I am bipolar, and possibly schizo-affective, but not schizophrenic, unless you want to combine a schizophrenia diagnosis with a bipolar type I.

When I'm manic, I sometimes get funny ideas some of which can be regarded as delusions (but see below). These delusions last for considerable time after the mania is over, hence I am possibly schizo-affective, but the bipolarity is the primary issue, and the psychosis (at least its inception) is secondary to that.

Historically, more than 10 years ago, I had a full-blown psychosis resembling paranoid schizophrenia. In addition to the paranoia, I had auditory hallucinations. These hallucinations resolved quickly, in the matter of days or weeks, and they have never recurred.

Or, do I have delusions? Citing DSM-V: "Delusions are fixed beliefs that are not amenable to change in light of conflicting evidence.". I don't have beliefs that I cling to in the face of evidence to the contrary. I do have beliefs and hypotheses that have little or no basis in conventional science, but they also cannot be disproven. If I say I have delusions, I am conceding that some of these may qualify as delusions.

Have I *had* delusions? Yes.

-undopaminergic

 

Re: Tardive dyskinesia

Posted by Lamdage22 on March 27, 2020, at 2:50:40

In reply to Re: Tardive dyskinesia, posted by undopaminergic on March 26, 2020, at 12:26:30

You have been through a lot.

 

TRe: Tardive dyskinesia undopaminergic

Posted by Jadde on March 27, 2020, at 20:56:55

In reply to Tardive dyskinesia, posted by undopaminergic on March 25, 2020, at 13:50:54

> I read the Wikipedia article on tardive dyskinesia (TD):
> https://en.wikipedia.org/wiki/Tardive_dyskinesia
>
> It reports an alarming prevalence of TD.
>
> "Rates in those on atypical antipsychotics are about 20%, while those on typical antipsychotics have rates of about 30%."
>
> "A study being conducted at the Yale University School of Medicine has estimated that "32% of people develop persistent tics after 5 years on major tranquilizers, ..."
>
> But this does not appear to be true. My psychologist, who has worked at "my" hospital for a long time, says she used to see people around here who had symptoms of TD, but she doesn't see this any more. My own personal observations are in agreement with this, because I have seen 0 cases myself, either here or in another hospital I was at. Almost all patients here are receiving treatment with anti-psychotics, yet there is very little, if any, TD.
>
> Has anyone here experienced TD?
>
> -undopaminergic
>

It was either TD, RLS or something similar. I was taking Abilify at the time and had to keep moving my legs. Hard to explain but it wasnt pleasant.

 

Re: TRe: Tardive dyskinesia Jadde

Posted by undopaminergic on March 28, 2020, at 4:45:55

In reply to TRe: Tardive dyskinesia undopaminergic, posted by Jadde on March 27, 2020, at 20:56:55

>
> It was either TD, RLS or something similar. I was taking Abilify at the time and had to keep moving my legs. Hard to explain but it wasnt pleasant.
>

That is not TD, but either RLS or akathisia. Did you experience a "central" or "inner" restlessness, or was it "peripheral", focussed in your legs? Did your legs feel uncomfortable, and was this discomfort temporarily relieved by moving your legs? Was it worse in the evening and night, or was it the same regardless of time of day?

-undopaminergic

 

Re: TRe: Tardive dyskinesia undopaminergic

Posted by Jadde on March 28, 2020, at 13:53:54

In reply to Re: TRe: Tardive dyskinesia Jadde, posted by undopaminergic on March 28, 2020, at 4:45:55

> >
> > It was either TD, RLS or something similar. I was taking Abilify at the time and had to keep moving my legs. Hard to explain but it wasnt pleasant.
> >
>
> That is not TD, but either RLS or akathisia. Did you experience a "central" or "inner" restlessness, or was it "peripheral", focussed in your legs? Did your legs feel uncomfortable, and was this discomfort temporarily relieved by moving your legs? Was it worse in the evening and night, or was it the same regardless of time of day?
>
> -undopaminergic
>

It wasnt in my legs specifically, it was an inner restlessness. I remember trying to stay seated and it was impossible. I had to move. I recall that it was worse during the day. It was very uncomfortable to say the least.

 

Re: TRe: Tardive dyskinesia

Posted by Lamdage22 on March 28, 2020, at 14:05:34

In reply to Re: TRe: Tardive dyskinesia undopaminergic, posted by Jadde on March 28, 2020, at 13:53:54

I reacted well to many meds but akathisia prevented me from staying on them. There is no use if the depression is replaced with equally disturbing akathisia.

Most notably: Sertraline (zoloft) in a homeopathic dosage

 

Re: TRe: Tardive dyskinesia Jadde

Posted by undopaminergic on March 28, 2020, at 14:06:38

In reply to Re: TRe: Tardive dyskinesia undopaminergic, posted by Jadde on March 28, 2020, at 13:53:54

> > >
> > > It was either TD, RLS or something similar. I was taking Abilify at the time and had to keep moving my legs. Hard to explain but it wasnt pleasant.
> > >
> >
> > That is not TD, but either RLS or akathisia. Did you experience a "central" or "inner" restlessness, or was it "peripheral", focussed in your legs? Did your legs feel uncomfortable, and was this discomfort temporarily relieved by moving your legs? Was it worse in the evening and night, or was it the same regardless of time of day?
> >
> > -undopaminergic
> >
>
> It wasnt in my legs specifically, it was an inner restlessness. I remember trying to stay seated and it was impossible. I had to move. I recall that it was worse during the day. It was very uncomfortable to say the least.
>

That is almost certainly akathisia.

-undopaminergic


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