![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by rjlockhart37 on January 17, 2020, at 18:56:46
i've been doing research, i can't find any accurate articles that compare the two. All i know is that selegiline is a selective MAO-B, and it increases dopamine levels, and used for parkinson disease. Yet it said it's not a indicator as antidepressant. But many people here have taken ENSAM patch and said it worked wonders. Parnate is a non selective MAO-b and from i what i read, they say it's more antidepressant properties, yet it does increase dopamine. I used to be able to find answers on the web, but its like some of the details disappeared. All i know is parnate is potent, but has lots of side effects more than selegiline. But ... question, which is more difference, in potency or mechanism of action, selegiline is a "selective" MAO-b, which it directly increases dopamine levels.
If anyone has taken them, whats the difference, is parnate more potent, or is more antidepressant effects. I read people take d-amphetamine with parnate and experienced major relief from treatment resistant depression. Yet alot doctors today use selegiline with a stimulant to add on to its effect.
Does anyone know the exact difference in their pharmacology? or how they effect the nervous system, i frequently read parnate also works on MAO-A also. It's not used to treat or effective in Parkinson's disease
any evidence or experiences between these two, bedes parnate being a older medication
Posted by undopaminergic on January 18, 2020, at 6:55:35
In reply to selegine vs parnate, posted by rjlockhart37 on January 17, 2020, at 18:56:46
I don't have much information to share on the topic.
However, one difference is that selegiline gets metabolised into l-amphetamine and l-methamphetamine, There is an article suggesting tranylcypromine (Parnate) also metabolises to amphetamine, but this has not been confirmed by other studies.
Parnate has an intrinsic amphetamine-like action, whereas selegiline has this effect through the metabolites.
Per milligram, it appears selegiline is more potent.
The l-amphetamines of selegiline can cause cardiovascular effects that tranylcypromine does not have.
-undopaminergic
Posted by greg rizzo on January 18, 2020, at 15:30:30
In reply to Re: selegine vs parnate, posted by undopaminergic on January 18, 2020, at 6:55:35
Go to these 2 sites. Not going to copy/paste them. They're too long, but very good info on all MAOI's---
1.https://www.thecarlatreport.com/category/the-carlat-psychiatry-report/
2. https://pro.psychcentral.com/this-months-expert-jonathan-cole-m-d-reflections-on-the-use-of-maois/
Posted by rjlockhart37 on January 18, 2020, at 19:05:47
In reply to Re: selegine vs parnate, posted by greg rizzo on January 18, 2020, at 15:30:30
i researched it, Parnate is for treatment resistant, is potent one. It effects MAO-B but also MAO-A partly, i read reviews about depression, on websites, it has a high rating of depression treatment, but the only about Parnate is you have to take 3 times a day, or you'll have the fatigue, and also it said if you take it too late insomnia is an issue, have to have a sedative to go to sleep.
Selegiline - its indicated for parkinson's disease, which it is selective MAO-B, more selective than Tranylcypromine, that it increases dopamine levels, directly. That one of the reasons why its used in parkinson's. I read Tranylcypromine is not as effective as selegiline in parkinson's. ENSAM patch, many people ... here in the past had the patch, and i read good reviews of it. Seleigine yes, its metabolites are levoamphetamine, and amphetamine.
Yet, from what i've read is so many good reports about it, but also they said side effects are many. Obviously there is TONS of posts from previous discussions here ob babble from years ago, tons of them, i just don't want to go through the 1000s of pages about it. Needle in large haystack. But yeah, they said parnate is stimulating, and has brought relief of depression, but the side effects are more than selegiline. Tranylcypromine is non-selective MAO-b, it treats depression a bit more than selegiline. My doctor said they had a patient take ENSAM patch with a stimulant, i don't vyvanse or something for their ADHD. There was a poster, i credit what you said, they took desoxyn and parnate - and they said absolute relief of depression. I don't know, Parnate has wider view of treatment, but more effects. Plus taking 3 times a day
if there's any posters who know more info, that would be great, SLS, so many poster from the past that are gone now
Posted by undopaminergic on January 19, 2020, at 6:59:57
In reply to Re: selegine vs parnate, posted by rjlockhart37 on January 18, 2020, at 19:05:47
> i researched it, Parnate is for treatment resistant, is potent one. It effects MAO-B but also MAO-A partly,
>It has a slight preference for MAO-B, but it is usually regarded as non-selective. At moderate to high doses it potently inhibits both MAO-A and -B.
> i read reviews about depression, on websites, it has a high rating of depression treatment, but the only about Parnate is you have to take 3 times a day, or you'll have the fatigue,
>If you need the stimulant effect of it, yes, you have to take it more frequently, but for the MAO-inhibition, a single dose per day is enough.
I would say, it is better to take a stimulant additionally, rather than depend on the stimulant effect of tranylcypromine (Parnate).> Selegiline - its indicated for parkinson's disease,
And the EMSAM form is indicated for depression.
> which it is selective MAO-B, more selective than Tranylcypromine, that it increases dopamine levels, directly.
>They both do.
> That one of the reasons why its used in parkinson's. I read Tranylcypromine is not as effective as selegiline in parkinson's. ENSAM patch, many people ... here in the past had the patch, and i read good reviews of it. Seleigine yes, its metabolites are levoamphetamine, and amphetamine.
>Only the levo-isomers, of both amphetamine and methamphetamine.
> if there's any posters who know more info, that would be great, SLS, so many poster from the past that are gone now
>Yes.
-undopaminergic
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.