Psycho-Babble Medication Thread 1107812

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Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by undopaminergic on January 13, 2020, at 3:15:31

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by atypical on January 12, 2020, at 23:38:22

> > Why doesn't simply taking more Nardil fix the problem?
>
> I think if jt is not getting absorbed properly in the first place, increasing the dose will not help. Sort of like filling a cup with a big hole in it. The water never fills up, even if you increase the amount of water being poured.
>

If the bioavailability of ("new") Nardil were 0%, you would be right. For example, hypothetically, if the bioavailability of old Nardil were 100% and only 50% for the new Nardil, then taking the double amount of new Nardil would be equivalent to taking a normal dose of the old Nardil.

-undopaminergic

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 3:31:21

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:15:31

When I took in excess of 90mg Nardil, I went hypertensive. 180 or 190. So... do you know what I am trying to say?

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by undopaminergic on January 13, 2020, at 3:40:17

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 3:31:21

> When I took in excess of 90mg Nardil, I went hypertensive. 180 or 190. So... do you know what I am trying to say?
>

I suppose you're suggesting that taking higher doses of Nardil can be risky. But if bioavailability were only 50% of normal, you could take double the normal dose without getting more phenelzine into your circulation.

-undopaminergic

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 3:41:42

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:40:17

I think if there is a problem, it can be fixed by taking more. It might be a waste of time and energy to try to make the old Nardil.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by undopaminergic on January 13, 2020, at 3:52:50

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 3:41:42

> I think if there is a problem, it can be fixed by taking more. It might be a waste of time and energy to try to make the old Nardil.
>

I'm also wondering whether there might be a bit of placebo at play here.

-undopaminergic

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 3:59:58

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 12, 2020, at 13:23:42

Seems not to help because no matter how much you take, it is broken down by the acidic nature of the stomach and then I believe it is processed and excreted by the liver. It never gets the chance to get to the int6estinal tract where effective absorption occurs.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:01:32

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by atypical on January 12, 2020, at 23:38:22

CORRECT ATYPICAL.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:06:02

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 3:31:21

Yes I do and the question is: did you enjoy your hypertensive crisis that could have ended your luife?
Would you like to try that dose again and end up in th ER or worse.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:08:58

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 13, 2020, at 4:06:02

Relax, I just took some nifedipine. It's not like I just waited for it to pass.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:09:42

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:52:50

That is my suspicion, also.

> I'm also wondering whether there might be a bit of placebo at play here.
>
> -undopaminergic
>

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:12:48

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:40:17

I don't know about that. I get your theory but I just know if doing this and risking a hypertensive crisis is likely not worth the risk.

Good point that you make. I'll confess I just don't the answer you're looking for.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:15:40

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 3:41:42

To each his own.

I'm going to try my method and I would be very interested to see if your method works. Let me know your results.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:16:39

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 13, 2020, at 4:12:48

Sorry if there was a misunderstanding. I don't suggest that you do what i did. This was 9 years ago and I was maybe 21. You could however talk to your doctor and see what he thinks about raising the dose. The hypertension was created by taking WAY more. Not just a little more. In what ways are you not covered by Nardil? Depression or Anxiety?

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:18:29

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 13, 2020, at 4:15:40

@greg: I didn't take Nardil for 8 years, because it sent me into major psychosis. I think you misunderstood. I'm just saying that if it wasn't absorbed, then why did I get a hypertensive crisis?

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:19:00

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:52:50

With all due respect I don't agree.

By all means, increase your dose of nardil you believe will work and apprise me of your results.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:27:06

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 4:18:29

Not positive but the could have too high a dosage of nardil, but also there are so many medications that are contraindicated for use with nardil. There are a ton of meds that could cause a hypertensive crisis. It's somewhat different for each individua, but I have reacted adversely to cold meds, too much caffeine, tramadol, SSRI', Robitussin and a multitude of others.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:27:29

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 13, 2020, at 4:19:00

Relax and read what I wrote before your last post. God knows what would have happened if I had taken the "old" Nardil... I'm glad if it is now less effective because psychosis just would have been worse. If it is enough to send me into psychosis, then it IS absorbed.

And by your logic, your changing the formula will just raise the blood level which would be the same as taking more. So in theory you could also get a hypertensive crisis.

Try it if it is safe and let us know.


 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:29:11

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 4:27:29

And after all, a positive placebo effect is better than no positive effect.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:31:30

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:52:50

I don't know about the placebo at play. Don't think so but I'm no expert.

I firmly believe taking more nardil will not help due to degradation of nardil by the stomach acid.

But hey---go for it. Take a bunch more nardil & let me know if it works.

 

Re: augmentation of Nardil Experiment/Trial

Posted by Lamdage22 on January 13, 2020, at 4:31:38

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 4:29:11

I would invest the time and money into supplements. Also is no reason to shout.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:39:01

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 3:41:42

i don't agree so it's ok we agree to disagree.

It is my time and energy to try to make nardil more effective. You refer to it as "being a waste of my time and effort to make nardil more effective again."
So if it's a waste of time and enery to try to get nardil to work better, I'll honor your wishes and not report my findings to you, especially if they are very successful.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:40:21

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 13, 2020, at 4:31:30

Why would I take Nardil if it makes me psychotic? I haven't taken Nardil in 8 years...

I'm out!

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 13, 2020, at 4:45:07

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 4:16:39

I have both depression. I n meeting with my Dr. he believes I may be on the right track. Only time will tell.
He too believes that an inceased dose may not be effective due to the stomach acid basically destroying nardil's bioavailabily.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 4:57:56

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 4:40:21

Good luck. Nardil is not for me in neither version. You can consider yourself lucky that you can tolerate dopaminergic medications. I can't. Although I certainly lack it in a way. Replacing depression with psychosis is not a good bargain!

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by undopaminergic on January 13, 2020, at 7:19:30

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 13, 2020, at 3:59:58

> Seems not to help because no matter how much you take, it is broken down by the acidic nature of the stomach and then I believe it is processed and excreted by the liver. It never gets the chance to get to the int6estinal tract where effective absorption occurs.
>

There is an easy way to find out if that is true. Take a dose of it, and then take a blood sample and have it analysed for phenelzine concentration.

I doubt the bioavailability is 0%.

-undopaminergic


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