Psycho-Babble Medication Thread 1107812

Shown: posts 1 to 25 of 48. This is the beginning of the thread.

 

TO UNDOPAMINERGIC

Posted by greg rizzo on January 10, 2020, at 16:56:50

TO UNDOPAMINERGIC. IN RESPONSE TO YOUR COMMENT TO ME:
-------------------------------------
I'LL SAY IT AGAIN JUST TO PISS YOU OFF. I'M NEW HERE SO BITE ME.
YOU POST MORE REPETITIVE CRAP THAN ANYONE ELSE HERE.
MOST OF WHAT YOU POST IS COPIED FROM THE NET WITH LITTLE OR NO PERSONAL NOR ORIGINAL EXPERIENCE.

 

Re: TO UNDOPAMINERGIC

Posted by linkadge on January 10, 2020, at 19:43:32

In reply to TO UNDOPAMINERGIC, posted by greg rizzo on January 10, 2020, at 16:56:50

I agree with you Greg:

If Undopaminergic took a few milliseconds to complete a rudimentary Google / PubMed search, he would very quickly come to the conclusion that Modafinil does have effects on serotonergic neurotransmission (most studies suggesting an augmentative effect, independent of the serotonin transporter).

https://www.ncbi.nlm.nih.gov/pubmed/15668907
https://www.ncbi.nlm.nih.gov/pubmed/22512571
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/
https://www.modafinil.com/serotonin.html

Linkadge


 

Re: TO UNDOPAMINERGIC

Posted by undopaminergic on January 11, 2020, at 3:51:49

In reply to Re: TO UNDOPAMINERGIC, posted by linkadge on January 10, 2020, at 19:43:32

> I agree with you Greg:
>
> If Undopaminergic took a few milliseconds to complete a rudimentary Google / PubMed search, he would very quickly come to the conclusion that Modafinil does have effects on serotonergic neurotransmission (most studies suggesting an augmentative effect, independent of the serotonin transporter).
>
> https://www.ncbi.nlm.nih.gov/pubmed/15668907
> https://www.ncbi.nlm.nih.gov/pubmed/22512571
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/
> https://www.modafinil.com/serotonin.html

I stand (slightly) corrected.

I've reviewed the literature on modafinil before, and I just haven't come across any sources suggesting serotonergic actions of modafinil, probably because it is a marginal phenomenon.

-undopaminergic

 

Re: TO UNDOPAMINERGIC » greg rizzo

Posted by undopaminergic on January 11, 2020, at 3:57:23

In reply to TO UNDOPAMINERGIC, posted by greg rizzo on January 10, 2020, at 16:56:50

> TO UNDOPAMINERGIC. IN RESPONSE TO YOUR COMMENT TO ME:
> -------------------------------------
> I'LL SAY IT AGAIN JUST TO PISS YOU OFF. I'M NEW HERE SO BITE ME.
> YOU POST MORE REPETITIVE CRAP THAN ANYONE ELSE HERE.
> MOST OF WHAT YOU POST IS COPIED FROM THE NET WITH LITTLE OR NO PERSONAL NOR ORIGINAL EXPERIENCE.
>

I don't recall doing that. Maybe occasionally at most. Or can you back up your accusations?

What does being new here have to do with posting duplicates or writing in all uppercase?

-undopaminergic

 

Re: TO UNDOPAMINERGIC » undopaminergic

Posted by linkadge on January 11, 2020, at 8:02:48

In reply to Re: TO UNDOPAMINERGIC, posted by undopaminergic on January 11, 2020, at 3:51:49

>I've reviewed the literature on modafinil before, >and I just haven't come across any sources >suggesting serotonergic actions of modafinil, >probably because it is a marginal phenomenon.

Neither you nor I know the extent of the effect. The fact is that it DOES have documented (perhaps indirect) effects on the serotoninergic system. The mechanism of modafinil is complex and might (speculation here) affect serotonin via a histaminergic mechanism.

Linkadge

 

Re: tO linkage

Posted by greg rizzo on January 11, 2020, at 9:48:19

In reply to Re: TO UNDOPAMINERGIC, posted by linkadge on January 10, 2020, at 19:43:32

To linkage-thanks so much for your message. You have no idea how much your kind words mean to me.
Hope I can call you friend.
Argueably, I probably do more research on depression remission than most. Apologize in advance for the length of this post as I would like to run everything by you & possibly work together,
First of all, we all know stomach acic is the main culprit preventing nardil to reach the intestinal tract. To try to avoid this from happening I encase the 75 mg of nardil I take into size 0 enteric cellulose capsules (Amazon source).
Secondly is has been reported that Bioperine aids in the absorbtion of nutients and medications, so take that (Amazon). thirdly, since stomach acid seems to be the culprit, I take an ant-acid before taking the encapsulated nardil tablets. For now simply use Rolaids.
About every 2nn or 3rd day I take Provigil. The depression immediately disappears. I don't want to take it every day in order to prevent tolerance build up.
If these methods fail to work my next step would be to coat the nardil tablets in carnuba wax. This was the coating on thr'old nardil.' Has a boiling point of 80 degrees I believe so heat the wax, put in the nardil, let cool.
Nearly all of these ingredients I use are very inexpensive except for the provigil. If you are interested contact me privately (glrizzz@aol) and I can provide you with a non-script very cheap source--a little less than $1 per 200 mg tablet compared to around $600 give or take, for 30 tabs at pharmacies.
Below are some studies and possible solutions to depression remission.
AND PLEASE PEOPLE OUT THERE--DON'T WRITE JUST TO BITCH ABOUT SOME OF MY INFO ACCURACY. DOING THE BEST CAN TO BE ACCURATE, BUT I'M NOT PERFECT!
------------------------------------------
The Gavis brand of Nardil is regarded by many as being the closest to the old formula regarding ingredients/absorption but in no way resembles efficacy of Park Davis version.
------------------------------------------------------------------
Palmitoylethanolamide (PEA) caused a reduction of food intake, body weight, and fat mass.
--------------------------------------------------
AUGMENTING NARDIL STRATEGY: Response to Phenelzine WITH Diazepam:
Results of a Nine Hospital Collaborative Study Allen Raskin, PhD; Joy G. Schulterbrandt,
-A total of 325 depressed patients from nine hospitals were randomly assigned to treatment with either diazepam, phenelzine, or a placebo. Dosages were 30 mg of diazepam and 45 mg of phenelzine.
The findings were that there was a significant number of anxious-depressive patients who were diazepam responders--their symptoms subsided on this treatment and became worse when this drug was discontinued.
-------------------------------------------
COMMENTS -
1. ***It is possible that the current version OF NARDIL is not surviving the stomach acid content." Use antacid? enteric capsules and wax?
----------------------------------------------------------------------------
2." Nicotine boosts my dopamine back to normal, and it releases another chemical called acetylcholine (too much acetylcholine however, can cause depressive/anxiety symtoms) which helps thinking/processing. I quit smoking and now I constantly have to drink caffeine, or take l-tyrosine to keep my dopamine normal.
-------------------------------------------------------------------------------------
3. "New NARDIL metabolizes so fast it may be helpful to space dosage to three times daily
--------------------------------------------------------------------------------
4. The new nardil seems to have lost a lot of its anxiolotic properties/social phobia. *Neurontin will help because it helps the new nardil boost its gaba level properties.
-------------------------------------------------------------------------
5. **Bioperine "I have been taking bioperine with nardil for six weeks now and can tell a big difference. The anxiety and depression are gone."
---------------------------------------------------------------------
6. -olanzapine--"PARNATE just stopped working altogether even when I then increased it back up to 40mg per day. However, after a couple of weeks on olanzapine, it started working again! A total miracle !"
------------------------------------------------------------------------------------
-acetylcholine--too much can cause depressive/anxiety symptoms.
-**coat nardil with carnuba or beeswax wax similar to the coating used in the Park Davis formula. (SEE BELOW)
---------------------------------------------------------------------
Test describing enteric and wax coating of nardil tablets:
A new article described testing tablets enteric coated tablets (COMPRISING OF A LAYER OF A CELLULOSE DERIVATIVE CONTAINING FREE CARBOXYL GROUPS AND A LAYER OF beeswax or other suitable wax LIKE CARNUBA WAX.) SAID WAX LAYER's INTEGRITY WILL BE MAINTAINED IN THE STOMACH AND WILL BE UTILIZED IN THE INTESTINE. According to this test, it resulted in no penetration by fluids of the stomach for a period of ten" hours and disintegration in about one hour in the intestine. This test gives creedence to the use of an enteric coating which is insoluble and not dispersible in and impermeable by the fluids of the stomach, and non-rupturable by agitation in the stomach. At the same time, it is readily absorbed/dissipated by the fluids of the intestines.
--------------------------------------
Potential Root Cause of Depression Discovered by NARSAD Grantee:
Charles BG Murphy Professor in Psychiatry and Deputy Chair for Basic Science
Yale School of Medicine Scientific Council Member (Joined 2015) 2016 Distinguished Investigator Grant 2004 Independent Investigator Grant 1996 Young Investigator Grant
-----------------------------------------------------------------------------------
A Yale study has made a discovery pointing to the importance of a signaling system in the brain that was not previously believed to be central in causing depression.
For decades, many scientists have favored a theory of depression that stresses the impact of abnormally low levels of a signal-carrying chemical, called serotonin. The new research shifts attention to a different signaling chemical, or neurotransmitter, called acetylcholine.

Millions of depressed people take anti-depressant drugs that act to keep message-carrying serotonin molecules from being rapidly reabsorbed by nerve cells. By allowing serotonin to float for longer periods of time in the tiny spaces between nerve cells, called synapses, scientists have theorized the SSRI drugs promote signaling by compensating for abnormally low serotonin levels.

**Yale's new research, focuses on fluctuations in levels of the neurotransmitter acetylcholine and the larger chemical signaling system it is part of, called the cholinergic system.
Serotonin may be treating the problem,, but acetylcholine disruption may be a primary cause of depression. If we can treat the root cause, perhaps we can get a better response from the patient.

The experiments demonstrate that abnormally high levels of acetylcholine in the brain can cause depression and anxiety symptoms. In the brains of non-depressed peoplean enzyme called acetyl-cholinesterase (AChE) is produced to lower acetylcholine levels. The team showed that when depressed people were given Prozac®, AChE levels were raised, and abnormally high levels of acetylcholine were thus brought under control adding a new dimension to understanding how and why SSRI anti-depressants can alleviate depression.

Yet many depressed people do not get a therapeutic benefit from many medications. The new research suggests this may be because the root problem is not low levels of serotonin, but rather, high levels of acetylcholine. By experimentally blocking the ports, called receptors, where acetylcholine molecules dock with nerve cells in the brain, the team was able to reverse depression.
In still other experiments, the Yale team showed how interruptions in acetylcholine signaling in the brain area called the hippocampusimportant in memory and moodpromotes depression and anxiety.

With this new hypothesis that it is the disruption of acetylcholine, and not serotonin, that sets depression in motion, further research studies can be undertaken to determine if medications that target acetylcholine rather than serotonin, are more effective in treating depression.
--------------------------------------------------------------------------
-**enteric empty capsules to encase nardil-currently doing this
-NARDIL with aripiprazole may be considered with a cautious approach
-psilocybin
-antibiotics---amoxicilin?
-INVERT SUGAR TO INCREASE ABSORBTION in the intestinal tract?
-------------------------------------------------------------
-Bupropion/MAO Inhibitors-Some patients have experienced good results combining wellbutrin with nardil.Make sure your dr. knows you are taking these medicines together.
--------------------------------------------------------
-an atypical antipsychotic medication (SEE BELOW), and N-Acetylcysteine
---------------------------------------------------------------------
-Atypical antipsychotics studied include aripiprazole, risperidone, quetiapine, olanzapine and aripiprazole. Two meta-analyses have confirmed the efficacy of this strategy. Conclusion was that that these anti-psychotics were effective as augmentation agents.
---------------------------------------------------------------------
-lithium--The evidence for lithium augmentation of antidepressants is a viable option.
-compound nardil?? too expensive?
-USE A dopamine reuptake inhibitor:
-Altropane (O-587): powerful reuptake inhibitor of dopamine-has long-acting effects.
-Difluoropine (O-620): some think may be illegal cuz similar to cocaine.
-Vanoxerine (GBR-12909): Considered extremely potent/selective. Inhibits -release of dopamine leading to a mild rise in dopamine, with subtle stimulant effect.
--Focalin is questionably the best dopamine reuptake inhibitor.
-----------------------------------------------------
-Gastric emptying: Involves taking Nardil on an empty stomach with large quantities of water. It may (in theory) empty into the intestines immediately, (assuming the stomach doesnt recognize the Nardil), and absorb it just as quickly. This theory has not been known to be tested, therefore results are questionable.
----------------------------------------------------------------------
PSYCHOSTIMULANT AUGMENTATION TO MAOI'S: Mental Health Professional: Dr. Z
If you still want to be on the Nardil, it would be best to combine the Nardil with a psychostimulant like Methylphenidate, because if you combine it with Nortriptyline then you may just cause too much Serotonin to be in the system. Typically for treatment resistant depression it would be best to add a psychostimulant as those are considered very effective. Adderall? ritalin? Focalin is the best?
---------------------------
HAYMARKET MEDICAL NETWORK MPR THE RIGHT DOSE OF MEDICATION May 1, 2015
CombinATION THEORY
A review in Pharmacotherapy evaluated data from 18 published studies and case reports on the safety/efficacy of combination therapy with MAOIs and other antidepressants or stimulants for TRD. Results FOLLOW:
--------------------------------------------------------
-MAOI + TCA
Small studies and case studies have led to mixed findings on MAOIs plus TCAs. While some have demonstrated safety, this combination is usually less well-tolerated than either agent alone. There is evidence that the combination is no more effective than either agent alone. However, in the case studies culled from the patient medical records in this review, sustained tolerability and efficacy was observed with an MAOI + TCA. The exception to this is clomipramine, which should not be used concomitantly with an MAOI.
-----------------------------------------------------------------------
-MAOI + Stimulants
Although stimulants are not indicated for treatment of depression, they are used as an augmentation strategy and are supported by evidence in the literature as to their safety with MAOIs. Stimulants could help to normalize blood pressure in patients experiencing hypotension due to MAOI.
-MAOI + Antidepressants + Stimulants
This combination has demonstrated efficacy in case reports, although the case studies from the hospital showed mixed results. While the literature supports cautious use of combining MAOIs with other antidepressants in patients with TRD who have failed multiple treatment modalities.


 

Re: TO UNDOPAMINERGIC

Posted by greg rizzo on January 11, 2020, at 9:57:11

In reply to Re: TO UNDOPAMINERGIC, posted by undopaminergic on January 11, 2020, at 3:51:49

BULL....

YOU HAVE ABSOLUTELY NO CLUE WHAT YOU'RE TALKING ABOUT REGARDING THE INFO THAT YOU COPIED FROM THE INTERNET.. IT IS VERY OBVIOUS YOU JUST HATE BEING WRONG.

 

Re: TO UNDOPAMINERGIC » linkadge

Posted by undopaminergic on January 11, 2020, at 9:58:26

In reply to Re: TO UNDOPAMINERGIC » undopaminergic, posted by linkadge on January 11, 2020, at 8:02:48

> >I've reviewed the literature on modafinil before, >and I just haven't come across any sources >suggesting serotonergic actions of modafinil, >probably because it is a marginal phenomenon.
>
> Neither you nor I know the extent of the effect. The fact is that it DOES have documented (perhaps indirect) effects on the serotoninergic system. The mechanism of modafinil is complex and might (speculation here) affect serotonin via a histaminergic mechanism.
>

Adrafinil, of which modafinil is the active metabolite, was so called because it was thought to be an agonist at alpha1-adrenoceptors. My hunch is that there are downstream effects of this, such as functional (not necessarily directly related to changed concentrations) modulation of several neurotransmitter systems, which may well include serotonin and histamine, and not unlikely dopamine, the latter of which may work synergistically with the dopamine reuptake inhibition activity of the drug. There is some evidence that there is a central system that uses adrenaline (epinephrine) as the neurotransmitter, and this using alpha1B (and maybe beta2 and beta3), in particular, as its preferential target receptors.

This report focusses on a central adrenaline-activated system:
https://www.nature.com/articles/1300222.pdf?origin=ppub

-undopaminergic

 

Re: tO linkage » greg rizzo

Posted by undopaminergic on January 11, 2020, at 10:17:27

In reply to Re: tO linkage, posted by greg rizzo on January 11, 2020, at 9:48:19

> AND PLEASE PEOPLE OUT THERE--DON'T WRITE JUST TO BITCH ABOUT SOME OF MY INFO ACCURACY. DOING THE BEST CAN TO BE ACCURATE, BUT I'M NOT PERFECT!
> ------------------------------------------

There were many good parts in this post.

That said, there were problems as well.

I refrain from further comment, lest you might feel I'm attacking you.

-undopaminergic

 

Re: TO UNDOPAMINERGIC » greg rizzo

Posted by undopaminergic on January 11, 2020, at 10:28:46

In reply to Re: TO UNDOPAMINERGIC, posted by greg rizzo on January 11, 2020, at 9:57:11

> BULL....
>
> YOU HAVE ABSOLUTELY NO CLUE WHAT YOU'RE TALKING ABOUT REGARDING THE INFO THAT YOU COPIED FROM THE INTERNET.. IT IS VERY OBVIOUS YOU JUST HATE BEING WRONG.
>

Almost everyone hates to be wrong. Of course I dislike being proven wrong, but I appreciate constructive criticism, because it is better to learn something new rather than to remain ignorant about your errors.

It seems to me you are just angry because I complained about your duplicates. Can you not understand that it is annoying to be "nagged" at with 5+ copies of the same thing?

What have I copied from the Internet that you have a problem with? Seems to me you have copied a lot more from the Internet than I have.

AND WHY DO YOU THINK IT IS A GOOD IDEA TO WRITE EVERYTHING IN CAPITALS? IT IS NOT EASIER TO READ AND IT IS NOT EASIER TO UNDERSTAND. IT ALSO MAKES YOU LOOK LIKE A NEWBIE. DO YOU SEE OTHER PEOPLE HERE WRITING IN THIS STYLE? I'M DOING IT HERE JUST TO MAKE A POINT. (C) COPYRIGHT 2020 BY UNDOPAMINERGIC CORPORATION!!!

-undopaminergic

 

Re: tO DOPAMINIC

Posted by greg rizzo on January 11, 2020, at 10:55:47

In reply to Re: tO linkage » greg rizzo, posted by undopaminergic on January 11, 2020, at 10:17:27

THATS ALL YOU DO--ATTACK OTHER'S POSTS.

 

Re: tO DOPAMINIC » greg rizzo

Posted by undopaminergic on January 11, 2020, at 12:03:56

In reply to Re: tO DOPAMINIC, posted by greg rizzo on January 11, 2020, at 10:55:47

> THATS ALL YOU DO--ATTACK OTHER'S POSTS.

Some people are touchy and react adversely to some of my comments. In general, my comments are neutral with regard to value-judgments, rather, they pertain to facts not feelings. If I want to "attack" something, such as in the case of your duplicates, I make that clear enough, and even then, I attack the behaviour and not the person or personality behind it. I'm not against you, just against some of the things you are doing. I am pleased that you have stopped the duplicates.

I notice that you have not tried to back up any of your accusations, so I assume there is nothing to them. Obviously, you prefer to accuse and to argue rather than engage in any kind of constructive debate.

-undopaminergic

 

Re: TO UNDOPAMINERGIC

Posted by greg rizzo on January 11, 2020, at 12:11:19

In reply to Re: TO UNDOPAMINERGIC » greg rizzo, posted by undopaminergic on January 11, 2020, at 3:57:23

When you're new here you don't realize that somrtimes there is a delay in having your message posted or you have to refresh the page to show your posting. I didn't realize that.

Funny-you're the only who complained about the duplicate posting. Do you have an insecurity or low self esteem problem that can only be temporarily appeased by putting others down to make yourself feel better? Hmmmmm

 

Re: TO UNDOPAMINERGIC » greg rizzo

Posted by undopaminergic on January 11, 2020, at 12:21:48

In reply to Re: TO UNDOPAMINERGIC, posted by greg rizzo on January 11, 2020, at 12:11:19

> When you're new here you don't realize that somrtimes there is a delay in having your message posted or you have to refresh the page to show your posting. I didn't realize that.
>

Thank you for explaining. I understand it now. Before you explained, I did not understand why you were doing it.

> Funny-you're the only who complained about the duplicate posting. Do you have an insecurity or low self esteem problem that can only be temporarily appeased by putting others down to make yourself feel better? Hmmmmm
>

Sometimes, I can be irritable. I think it is in part related to my mood. It may also be that I find different things irritating than most people.

-undopaminergic


 

Re: TO UNDOPAMINERGIC

Posted by greg rizzo on January 11, 2020, at 12:31:37

In reply to Re: TO UNDOPAMINERGIC » greg rizzo, posted by undopaminergic on January 11, 2020, at 12:21:48

Nice message--thank you. Maybe we can start over in our relationsip. After all, were all seeking the same goal.
I too can be irritable, vindictive, overly sensitve or frustrated in solving our common proble. Sorry.

 

Re: tO linkage

Posted by greg rizzo on January 11, 2020, at 16:10:19

In reply to Re: tO linkage, posted by greg rizzo on January 11, 2020, at 9:48:19

Post by Dr. Bob:
Just found this post bt D. Bob. May be an old post to you but it's new to me about augmenting Nardil.
--------------------------------------------
From the descriptions of others, research and my own experiences, I believe there are two problems with the new nardil as compared to the old:
1) new nardil is absorbed before it reaches the new intestine
2) even if new nardil does reach the new intestine, the absorbtion *rate* is off balance

That's why placing nardil in plasmin plus enteric tabs were only partially effective. yes, more phenelzine would likely survive the trip through the stomach, but once the enteric tab dissolved, the nardil itself won't be absorbed to the maximum level without an excipient to aid it.
The best excipients to aid absorption into the small intestine are sugar invert (a.k.a. honey) and ethanol (alcohol). Sugar is quite good, but the absorbtion rate, though high, is relatively slow.

As far as absorption into the small intestine, NOTHING beats alcohol. It's rate and level of absorption by the small intestine is extremely high. Obviously, I don't mean kick back shots of tequila, I'm talking mere drops of the substance.

Therefore mixing nardil with either honey or alcohol has been much more effectiv

 

Re: TO UNDOPAMINERGIC » greg rizzo

Posted by undopaminergic on January 12, 2020, at 3:12:11

In reply to Re: TO UNDOPAMINERGIC, posted by greg rizzo on January 11, 2020, at 12:31:37

> Nice message--thank you. Maybe we can start over in our relationsip. After all, were all seeking the same goal.
> I too can be irritable, vindictive, overly sensitve or frustrated in solving our common proble. Sorry.
>

Sure, I'd rather be friends than enemies.

-undopaminergic

 

AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by greg rizzo on January 12, 2020, at 13:08:10

In reply to Re: TO UNDOPAMINERGIC, posted by greg rizzo on January 11, 2020, at 12:31:37

Some don't give a damn about what I'm about to post so just skip this post, go about your business, and spare me your criticism. I'm merely trying to improve the efficacy of nardil. Helpful suggestions are welcomed. So here goes:
--------------------------------------------
Facts we already know:
1.New nardil is too quickly metabolized and excreted mainly due to the acidic nature of the stomach. (or so the literature states). It is theorized that the carnuba wax coating on the old Nardil prevented this from happening. Again this is theorized.
So what can we do about the new lack of efficacy us old-timers notice compared to the old nardil formula.
---------------------------------------
Here's what I'm trying:
1.Encasing nardil tablets in empty enteric cellulose capsules.
2. Taking Bioperine which the literature says increases absorpyion and bioavailability of medication.
3. Taking an antacid hopefully to reduce the acidic nature of the stomach.
4. At Dr. Bob's suggestion, I take invert sugar honey) and a sip of alcohol. Dr. Bob's comments--"The best excipients to aid absorption into the small intestine are sugar invert (a.k.a. honey) and ethanol (alcohol). Sugar is quite good, but the absorbtion rate, though high, is relatively slow.
As far as absorption into the small intestine, NOTHING beats alcohol. It's rate and level of absorption by the small intestine is extremely high. Obviously, I don't mean gulp shots of tequila, I'm talking mere drops of alcohol.
Therefore mixing nardil with either honey or alcohol has been much more effective."
-------------------------------------------
End of dissertation, other than to say "I've only just begun to fight."

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 12, 2020, at 13:23:42

In reply to AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by greg rizzo on January 12, 2020, at 13:08:10

Why doesn't simply taking more Nardil fix the problem?

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by atypical on January 12, 2020, at 23:38:22

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 12, 2020, at 13:23:42

> Why doesn't simply taking more Nardil fix the problem?

I think if jt is not getting absorbed properly in the first place, increasing the dose will not help. Sort of like filling a cup with a big hole in it. The water never fills up, even if you increase the amount of water being poured.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by TH on January 13, 2020, at 3:01:47

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by atypical on January 12, 2020, at 23:38:22

> > Why doesn't simply taking more Nardil fix the problem?
>
> I think if jt is not getting absorbed properly in the first place, increasing the dose will not help. Sort of like filling a cup with a big hole in it. The water never fills up, even if you increase the amount of water being poured.
>

To chime in without really reading:
I have a feeling there was a theory going around about it the differences coming from the site of absorption (stomach vs intestine) due to dissolution rate.

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by undopaminergic on January 13, 2020, at 3:15:31

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by atypical on January 12, 2020, at 23:38:22

> > Why doesn't simply taking more Nardil fix the problem?
>
> I think if jt is not getting absorbed properly in the first place, increasing the dose will not help. Sort of like filling a cup with a big hole in it. The water never fills up, even if you increase the amount of water being poured.
>

If the bioavailability of ("new") Nardil were 0%, you would be right. For example, hypothetically, if the bioavailability of old Nardil were 100% and only 50% for the new Nardil, then taking the double amount of new Nardil would be equivalent to taking a normal dose of the old Nardil.

-undopaminergic

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 3:31:21

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:15:31

When I took in excess of 90mg Nardil, I went hypertensive. 180 or 190. So... do you know what I am trying to say?

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by undopaminergic on January 13, 2020, at 3:40:17

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by Lamdage22 on January 13, 2020, at 3:31:21

> When I took in excess of 90mg Nardil, I went hypertensive. 180 or 190. So... do you know what I am trying to say?
>

I suppose you're suggesting that taking higher doses of Nardil can be risky. But if bioavailability were only 50% of normal, you could take double the normal dose without getting more phenelzine into your circulation.

-undopaminergic

 

Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL

Posted by Lamdage22 on January 13, 2020, at 3:41:42

In reply to Re: AUGMENTATION OF NARDIL EXPERIMENT/TRIAL, posted by undopaminergic on January 13, 2020, at 3:40:17

I think if there is a problem, it can be fixed by taking more. It might be a waste of time and energy to try to make the old Nardil.


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