Psycho-Babble Medication Thread 1107271

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Dextromethorphan/Bupropion for MDD soon.....

Posted by PeterMartin on December 16, 2019, at 14:18:39

A combo drug of Dextromethorphan & Bupropion has done well in trials. It's essentially Robitussin + Wellbutrin. I used to take Robitussin in excess and it definitely helped my mood a lot. I found taking it w/ Lamictal worked well to leave just the mood enhancing effects (and eliminate the "tripping" part).

Anyway, NDA next year. Sadly I'm sure they'll charge through the roof for it even though it's 2 chemicals that have had cheap generic versions available for ages. I think Nudexda (alzheimers) was a similar repurposing of Dextromethorphan that ran $500+ a month.

Info on it's trial success/NDA next year:

https://www.empr.com/home/news/novel-dextromethorphan-bupropion-formulation-provides-significant-benefits-in-mdd-trial/

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by rjlockhart37 on December 17, 2019, at 1:43:57

In reply to Dextromethorphan/Bupropion for MDD soon....., posted by PeterMartin on December 16, 2019, at 14:18:39

i've taken dextromethorphan, just feels like a nasty drg, but it increases serotonin i've read and actually people have reported euphoria and tipping experience, it does produce euphoria at moderate to higher doses, but don't like robitussin, i used ot know people would walk around with a bottle of robitussin, drinking it like a beer, nasty.

bupropion i don't know how this combo is gonna help people but leave it to the trial results

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by PeterMartin on December 17, 2019, at 3:05:50

In reply to Re: Dextromethorphan/Bupropion for MDD soon....., posted by rjlockhart37 on December 17, 2019, at 1:43:57

Dextromethorphan works the NMDA receptor so it's novel in that regard. There are other drugs (new) in trial that work by touching on NMDA.

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by Lamdage22 on December 17, 2019, at 5:46:36

In reply to Re: Dextromethorphan/Bupropion for MDD soon....., posted by PeterMartin on December 17, 2019, at 3:05:50

Cant, you just swallow both as separately pills you think it will help? For me that would be poison.. but whatever floats your boat.

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by Lamdage22 on December 17, 2019, at 5:48:09

In reply to Re: Dextromethorphan/Bupropion for MDD soon....., posted by Lamdage22 on December 17, 2019, at 5:46:36

Sorry, that was messed up but you get what I mean.

 

Re: Dextromethorphan/Bupropion for MDD soon..... PeterMartin

Posted by undopaminergic on December 17, 2019, at 11:06:25

In reply to Re: Dextromethorphan/Bupropion for MDD soon....., posted by PeterMartin on December 17, 2019, at 3:05:50

> Dextromethorphan works the NMDA receptor so it's novel in that regard. There are other drugs (new) in trial that work by touching on NMDA.
>

Dextromethorphan (DXM) is also a serotonin reuptake inhibitor. I noticed this myself. It is probably a sigma-receptor agonist too, but I'm not 100% sure about that.

It does work on NMDA. So does memantine, which was so "good" it made me manic. I was having so much fun just from YouTube. Alas, I got impulsive and took an overdose of a few grams, so I'm probably the world record-holder in the category of highest dose of memantine taken.

I'm not sure whether I was trying to kill myself... I guess I was a bit confused.

-undopaminergic

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by sigismund on December 17, 2019, at 21:35:20

In reply to Re: Dextromethorphan/Bupropion for MDD soon....., posted by rjlockhart37 on December 17, 2019, at 1:43:57

>just feels like a nasty drg

for me, yes

 

Re: Dextromethorphan/Bupropion for MDD soon..... PeterMartin

Posted by pedr on January 10, 2020, at 9:31:01

In reply to Dextromethorphan/Bupropion for MDD soon....., posted by PeterMartin on December 16, 2019, at 14:18:39

> A combo drug of Dextromethorphan & Bupropion has done well in trials. It's essentially Robitussin + Wellbutrin. I used to take Robitussin in excess and it definitely helped my mood a lot.

Hey Peter,

how did you take the DXM without feeling really nauseous and... gross? I tried taking it via "Robocough" and it was horrible, especially for me since I have IBS, which seemingly responded to it. Would tablets be worth a shot do you think?

Many thanks, Pete

 

Re: Dextromethorphan/Bupropion for MDD soon..... pedr

Posted by undopaminergic on January 10, 2020, at 11:03:50

In reply to Re: Dextromethorphan/Bupropion for MDD soon..... PeterMartin, posted by pedr on January 10, 2020, at 9:31:01

> Would tablets be worth a shot do you think?

Yes, absolutely.

I had an antidepressive response to a dextromethorphan (DXM) pill once. I figured it might be the serotonergic action, because the effect came so soon(*) and the dose was so low.

(*) the NMDA-antagonism comes largely from metabolism to dextrorphan; hence it takes some time till the onset.

DXM also binds to sigma-receptors. I'm not sure whether it is an agonist or antagonist.

-undopaminergic

 

Re: Dextromethorphan/Bupropion for MDD soon..... undopaminergic

Posted by pedr on January 10, 2020, at 12:23:01

In reply to Re: Dextromethorphan/Bupropion for MDD soon..... pedr, posted by undopaminergic on January 10, 2020, at 11:03:50

> > Would tablets be worth a shot do you think?
>
> Yes, absolutely.
>
> I had an antidepressive response to a dextromethorphan (DXM) pill once. I figured it might be the serotonergic action, because the effect came so soon(*) and the dose was so low.
>
> (*) the NMDA-antagonism comes largely from metabolism to dextrorphan; hence it takes some time till the onset.
>
> DXM also binds to sigma-receptors. I'm not sure whether it is an agonist or antagonist.
>
> -undopaminergic
>

thanks for the rapid response! so you didn't encounter any nausea?
Cheers, Pete

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by undopaminergic on January 10, 2020, at 12:59:32

In reply to Re: Dextromethorphan/Bupropion for MDD soon..... undopaminergic, posted by pedr on January 10, 2020, at 12:23:01

> thanks for the rapid response! so you didn't encounter any nausea?
> Cheers, Pete

No nausea.

-undopaminergic

 

Re: Dextromethorphan/Bupropion for MDD soon.....

Posted by creepy on January 13, 2020, at 20:35:43

In reply to Dextromethorphan/Bupropion for MDD soon....., posted by PeterMartin on December 16, 2019, at 14:18:39

For those who have tried this, can you remember how much DXM you took along with bupropion?


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